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Sovaldi (Sofosbuvir)
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Sovaldi

Sovaldi is a medication used to treat hepatitis C. It is only recommended with some combination of Sovaldi, peginterferon-alfa, simeprevir, ledipasvir, daclatasvir, or velpatasvir. Cure rates are 30 to 97% depending on the type of hepatitis C virus involved.

Other names for this medication:
Sofosbuvir

Similar Products:
Levitra, Cardura, Danocrine, Altace, Sporanox, Mircette

Also known as: Sofosbuvir

Description

{name} (sofosbuvir) is an antiviral medication that prevents hepatitis C virus (HCV) from multiplying in your body.

{name} is used to treat chronic hepatitis C in adults and children who are at least 3 years old.

{name} must be given in combination with other antiviral medications (usually ribavirin with or without peginterferon alfa). It should not be used alone.

{name} treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

{name} is sometimes used in people who also have HIV, or people who have liver cancer and are going to have a liver transplant. This medicine is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

400 mg orally once a day Recommended Regimen and Duration of Therapy: -Genotype 1 or 4: Sofosbuvir, peginterferon alfa, and ribavirin for 12 weeks -Genotype 2: Sofosbuvir and ribavirin for 12 weeks -Genotype 3: Sofosbuvir and ribavirin for 24 weeks -Hepatocellular carcinoma awaiting liver transplantation: Sofosbuvir and ribavirin for up to 48 weeks or until liver transplantation (whichever occurs first) Comments: -Genotype 1, 4: This regimen is recommended for therapy-naive patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Genotype 2, 3: Both regimens are recommended for therapy-naive and therapy-experienced patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Therapy-experienced patients have failed an interferon-based regimen (with or without ribavirin). -The dose recommendations for genotype 1, 2, 3, or 4 should be followed for HCV/HIV-1-coinfected patients. -The manufacturer product information should be consulted for ribavirin tablet dose recommendations; with genotype 1 or 4, the manufacturer product information for peginterferon alfa should also be consulted for dose recommendations. -Sofosbuvir and ribavirin for 24 weeks can be considered for patients with genotype 1 infection who cannot use an interferon-based regimen; treatment decision should be guided by benefit/risk assessment for the individual patient. -The regimen for patients with hepatocellular carcinoma awaiting liver transplantation is recommended to prevent posttransplant HCV reinfection. Use: As a part of a combination antiviral treatment regimen, for the treatment of chronic HCV infection -In combination with pegylated interferon and ribavirin: For genotype 1 or 4 infection without cirrhosis or with compensated cirrhosis -In combination with ribavirin: For genotype 2 or 3 infection without cirrhosis or with compensated cirrhosis

Usual Pediatric Dose for Chronic Hepatitis C:

3 years or older: -Weight less than 17 kg: 150 mg orally once a day -Weight 17 to less than 35 kg: 200 mg orally once a day -Weight at least 35 kg: 400 mg orally once a day Recommended Regimen and Duration of Therapy: -Genotype 2: Sofosbuvir and ribavirin for 12 weeks -Genotype 3: Sofosbuvir and ribavirin for 24 weeks -Hepatocellular carcinoma awaiting liver transplantation: Sofosbuvir and ribavirin for up to 48 weeks or until liver transplantation (whichever occurs first) Comments: -Both regimens are recommended for therapy-naive and therapy-experienced patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Therapy-experienced patients have failed an interferon-based regimen (with or without ribavirin). -The manufacturer product information should be consulted for ribavirin dose recommendations. -The same dose recommendations should be followed for HCV/HIV-1-coinfected patients. -The regimen for patients with hepatocellular carcinoma awaiting liver transplantation is recommended to prevent posttransplant HCV reinfection. Use: In combination with ribavirin, for the treatment of chronic HCV genotype 2 or 3 infection in patients without cirrhosis or with compensated cirrhosis

Detailed Sovaldi dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Sovaldi are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid taking an herbal supplement containing St. John's wort.

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent hepatitis C transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

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The effects of xenobiotics on fish tissues: morphological studies. This is attributed to the interference of light coupled into the resonators through multiple coupling regions as confirmed by a theoretical model based on coupled mode theory. Within each age group the proportion of presentations with ethanol intoxication was compared across the two time periods. Crosstalk between adaptive and innate immune cells leads to high quality immune protection at the mucosal borders. Single intravenous doses of 100 and 300 mg indoprofen and 0.5 and 1.5 Gm lysine acetylsalicylate (ASA) were compared in a four-point assay. Participants completed a projective test designed to elicit individual differences in perceptions of infant emotions and an observer-rated assessment of parenting behaviors was conducted in the family home. Effectiveness of pork insulin in 3 diabetics treated without success with beef insulin. stipitis in silica-hydrogel increased the relative consumption rate of xylose-to-glucose by 2-6 times depending on the composition of the fermentation medium. This study bears important implications for the molecular basis underlying antifolate resistance under hypoxia and its rational overcoming in solid tumors.

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T cells expressing cutaneous lymphocyte antigen (CLA), a unique skin-homing receptor, are known to play an important role in AD. The expression of IL-17A, E-cadherin, vimentin proteins and Snail mRNA were detected by immunohistochemistry and in situ hybridization histochemistry in the hepatocellular carcinoma (HCC) tissues of 74 patients. This analysis has provided the basis for the experimental verification of origins in the linear chromosome and in the linear plasmid Ip28-2. Infectious diseases in Switzerland at the dawn of the 21st Century. Spermiogenesis in commercial poultry species: anatomy and control. The interpretation and estimation of the summary vaccine efficacy were discussed in light of other two models of vaccine action: the leaky and all-or-nothing model. Participants also emphasised the need for leadership to overcome some of these obstacles and move towards genuine consumer and carer participation and reform. HBCD exposure significantly increased the expression of intercellular adhesion molecule (ICAM)-1 and the production of interleukin (IL)-6 and -8 in human bronchial epithelial cells (BEAS-2B).

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The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design. Secretory conglutinin-like factor SKF detects a cross-reaction between bacteria and complement component C3. In our efforts to better understand the factors that contribute to the accuracy of DNA replication, we have investigated whether frameshift mutations on the Escherichia coli chromosome occur differentially within the leading and lagging-strands of replication. We have analysed age-related changes in the morphology of preganglionic neurones in the lumbosacral spinal cord, labelled following injection of retrograde tracers into the major pelvic ganglion of young adult and aged male rats. That activity was due to GA-like substances was confirmed with dwarf-5 corn.When acidic, ethyl acetate soluble GA-like substances from sap and leaf extracts were chromatogrammed on thin layers of silica gel in chloroform/ethyl acetate/formic acid (50:50:1), activity moved to the same Rf as GA3 and GA1 (Rf 0.05-0.25). It is concluded that the pattern of HLA and diabetes association in Nigerian diabetics would appear to be different from that in most other racial groups including North American and South African blacks. Cyclosporine A, with or without methylprednisolone, induces mammary hyperplasia and hyperprolactinemia in NZW rabbits. These results represent the first report of a CP2 family member that is expressed in a developmentally regulated fashion in vivo and that acts as a direct repressor of transcription.

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Biphasic skin reactions during telaprevir-based therapy of Japanese patients infected with hepatitis C virus. Injections targeting the occipital nerve have raised interest for the management of CH. About half of the patients with disseminated disease receive palliative chemotherapy and of these, about one third are treated even during the last month of life. Thus, highly complex spatially addressed compound arrays have become accessible. Following the insertion of a single lesion in the chromosome of a living cell, we showed that this gap is mostly filled in by Homology Directed Gap Repair in a RecA dependent manner. Hexamethylene 1,6-diamino tetraacetic acid urispas tablet uses in telugu (TDTA), triethylene tetramine hexaacetic acid (TTHA), and ethylene diamine di (O-hydroxylphenyl acetic acid) (EDDHA) may be useful in preventing or reducing chromate toxicity.

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