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Plagerine (Clopidogrel)

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Plagerine is an antiplatelet medication. It prevents your platelets from clumping together into blood clots. This can lower the risk of heart attack, since most heart attacks are caused by a clot forming in the vessels supplying your heart. Plagerine also lowers the risk of stroke, since most strokes are caused by blood clots in the vessels supplying your brain.

Other names for this medication:
Aplatin, Asogrel, Atormac, Caplor, Cenoza, Cidogrel, Cloflow, Clolyse, Clopact, Clopiget, Clopigrel, Clopilet, Clopiriv, Clopisa, Clopivas, Clospir, Closprez, Clotsafe, Ecosprin, Kabitrol, Locric, Neogrel, Pidgrel, Plagerine, Platloc, Stagrel, Starclop, Synplatt, Thinrin, Thrombosprin, Torpido, Vivosprin, Zeter, Zogrell

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Also known as: Clopidogrel


{name} (clopidogrel) prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.

{name} is used to lower your risk of having a stroke, blood clot, or serious heart problem after you've had a heart attack, severe chest pain (angina), or circulation problems.


Usual Adult Dose for Acute Coronary Syndrome:

Unstable Angina (UA)/Non-ST-Elevation Myocardial Infarction (NSTEMI): -Loading dose: 300 mg orally once -Maintenance dose: 75 mg orally once a day -Duration of therapy: Optimal duration unknown. ST-Elevation Myocardial Infarction (STEMI): -Loading dose: 300 mg orally once (OPTIONAL) -Maintenance dose: 75 mg orally once a day, with or without thrombolytics -Duration of therapy: Optimal duration unknown. Comments: -Administer this drug in combination with aspirin 75 mg to 325 mg orally once a day. -The benefit of this drug for patients who undergo primary percutaneous coronary intervention is unknown. Uses: Prevention of atherothrombotic events in patients with non-ST-segment elevation acute coronary syndrome (UA, NSTEMI, those who are to be managed medically, those who are to be managed with coronary revascularization) and STEMI.

Usual Adult Dose for Ischemic Stroke:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Myocardial Infarction:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Usual Adult Dose for Peripheral Arterial Disease:

75 mg orally once a day Uses: Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Detailed Plagerine dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause excessive bleeding.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Plagerine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Plagerine if you are allergic to Plagerine components. Do not take Plagerine if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Plagerine if you suffer from or have a history of stroke, stomach ulcer or ulcerative colitis; liver or kidney disease, hemophilia. Be careful with Plagerine if you are taking such medicines as aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs such as naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ibuprofen (Motrin, Advil), (Toradol), ketoprofen (Orudis), nabumetone (Relafen), piroxicam (Feldene), ketorolac mefenamic acid (Ponstel), meloxicam (Mobic) and the others), phenytoin (such as Dilantin); torsemide (such as Demadex); medication used to prevent blood clots (alteplase (such as Activase), anistreplase (such as Eminase), dipyridamole (such as Persantine), streptokinase (such as Kabikinase, Streptase), ticlopidine (Ticlid) and urokinase (such as Abbokinase); fluvastatin (such as Lescol); a blood thinner (warfarin (such as Coumadin), heparin, ardeparin (such as Normiflo), dalteparin (such as Fragmin), danaparoid (such as Orgaran), enoxaparin (such as Lovenox), or tinzaparin (such as Innohep); tamoxifen (such as Nolvadex); tolbutamide (such as Orinase). It is not recommended to do sport while taking Plagerine because it can cause bleeding or bruising injury. If you are going to have a surgery you should stop taking Plagerine for 5 days before the surgery. Do not use potassium supplements or salt substitutes. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Do not stop taking Plagerine suddenly.

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It is well known that hyperandrogenism and insulin-resistance with or without compensatory hyperinsulinism are closely associated, but the Rotterdam Consensus has concluded that principally obese women with polycystic ovary syndrome (PCOS) should be evaluated for the metabolic syndrome. Concentrations and yields from rooftops were compared among locations and roofing material types and to loads monitored during runoff events in the receiving urban stream to evaluate rooftop sources and their potential contribution to stream loading. In performing its hemostatic function, fibrinogen in turn is acted on by several independent enzyme systems that either modify its structure or cleave specific fragments of the molecule into the surrounding milieu. Poor permeability and absorption affect the activity of four alkaloids from Coptis. We describe here the synthesis and properties of A-T rich DNA containing covalently bound water mimics located in the DNA minor groove. Is high pressure postdilation safe in bioresorbable vascular scaffolds?. Experience with paraquat poisoning in a respiratory intensive care unit in North India. Recent observations that cardiac myocytes may be coupled by multiple gap junction channel proteins having unique electrophysiologic properties provide new insights into potential mechanisms regulating intercellular current transfer in the heart. Outcome of acute vertebrobasilar occlusions treated with intra-arterial fibrinolysis in 180 patients. These results demonstrate the feasibility of improving the outcome of radiotherapy in dogs with large bulky tumours using iNOS gene therapy.

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To visualize the velocity gradients and the vorticities of physiological unsteady nasal flow using the computational fluid dynamics method and to compare the inspiratory phase and expiratory phase flow patterns. When the source and target organs were not identical, significant difference in SAF was observed which was mainly attributed to the difference in inter-organ distance and organ shape between voxel and stylised phantoms. Based on these data, the effects of electrotransfer of plasmid DNA were tested using the murine CIA model. The activity of the skin microbiota of amphibians against fungal pathogens, such as Batrachochytrium dendrobatidis, has been examined extensively, whereas its protective role towards the cutaneous infectious diseases caused by Amphibiocystidium parasites has not yet been elucidated in detail. A mouse xenograft tumor model was used to investigate the efficacy of ZB497 in comparison with tamoxifen. Treatment of recurrent lymphoceles following renal transplantation. In addition, we find that the AV77 holorepressor-DNA complex is much more stable than the equivalent WT complex, which has not been apparent from either in vitro or equilibrium binding experiments. Hordatine A and aperidine have been previously isolated from beer as active ingredients, which bind to muscarinic M3 receptor. Compared to visceral peritoneal non-closure, cesarean with visceral closure is associated with significant postpartum frequency of urination and/or incontinence that disappear without treatment almost completely within 6 months. Two reliablility-related equations are used to make decisions about weighting for a computerized performance assessment and a pattern recognition multiple-choice exam.

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Using a yeast two-hybrid screen of a T-cell cDNA library to identify cellular proteins that bind to the human immunodeficiency virus type 2 (HIV-2) Gag polyprotein, we identified PRP4, a serine-threonine protein kinase. Simultaneous determination of natural and synthetic estrogens by EKC using a novel microemulsion. Expression of vacJ and the yrb genes was positively correlated with serum resistance among clinical isolates. The K(D) was 3.9 nM at pH 7.5, 9.5 nM at pH 7.0 and 94.5 nM at pH 6.5. We consider two cognitive mechanisms underlying the emergence of this order: inference based on overall levels of aggression, or on subsets of the aggression network. The regulation of biotransformation started with the mechanism of mass action between the concentrations of the substrates (product) and enzyme.

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Accrual of diverse patient populations to cancer clinical trials is essential in order to ensure that findings related to new management strategies can be generalized. Comparison of mandibular cortical thickness and QCT-derived bone mineral density (BMD) in survivors of childhood acute lymphoblastic leukemia: a retrospective study. There is considerable evidence suggesting that alterations in DNA methylation play an important role in tumorigenesis and tumour progression. Resveratrol prevents embryonic oxidative stress and apoptosis associated with diabetic embryopathy and improves glucose and lipid profile of diabetic dam. The variation in the reported incidence and severity of OXCPN may be a consequence of differences in the baseline characteristics of patients. Addition of thiamine and benfotiamine to HG during ECM production completely prevented these damaging effects. The aim of this study was to determine whether reduction of hyperinsulinemia with rosiglitazone will improve vascular elasticity in patients with non-insulin dependent diabetes mellitus. English-language literature searches of MEDLINE (1966-September 2007) and the Cochrane Database (2007, Issue 3) were performed using the terms sipuleucel-T, APC8015, and prostate cancer vaccine. Decreasing Enterobacter sakazakii (Cronobacter spp.) food contamination level with bacteriophages: prospects and problems.

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The objective of the study was to compare the effect of horizontal versus vertical closure of the vaginal cuff during vaginal hysterectomy on vaginal length. In Group II, the glue without TGF-beta stimulation was wrapped around the frozen-thawed ACL. The long term impact of SRT (100-40 days) and recovery cleaning on membrane performance of an AnMBR treating authentic municipal wastewater in a large pilot plant was assessed. A left cortical dominance and asymmetry connectivity was observed in the anterior frontal during the verbal fluency task. This modulation can be an important step in the prevention of tissue damage and progression from the HTLV-1 carrier state to HAM/TSP. The photodynamic effect of methionine-riboflavin mixture (MR) on membranous system of living cells was examined using rabbit red blood cells (RBCs) as an assay system.

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The methodology is based on a telemedicine tasks ontology representing the concepts and their interrelations, and on a set of rules that shall be applied by a Reasoner for decision making. Baculovirus-mediated gene silencing in insect cells using intracellularly produced long double-stranded RNA. An examination of 23 vancomycin-resistant, streptococcuslike isolates of clinical origin revealed a group of 14 to be related to Leuconostoc lactis (type strain, CIP 102422) on the basis of chemotaxonomic studies. The study resulted in an intervention plan that included the wider work system and industry practices. Effects of methadone and morphine of the electroencephalogram of the dog. In this review, the structure, distribution, and functional relevance of these motifs are examined. We hypothesize that eprosartan leads to a resetting of the baroreflex, presumably by the markedly elevated circulating angiotensin II. Mixed input to olfactory glomeruli from two subsets of ciliated sensory neurons does not impede relay neuron specificity in the crucian carp.

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Proceedings: Synaptic vesicle magnesium-adenosine triphosphatase as a possible site of action of anticonvulsant drugs. Two fundamental concepts that are of the greatest importance are the Current Procedural Terminology coding and the Medicare Resource Based Relative Value Scale. Patients experience less frequency of short-term post-obturation pain after single-visit than those having multiple-visit root canal treatment. Inhibitory signaling has been implicated in the repression of the above activities as well as inhibition of B cell responses through Src homology 2-containing inositol phosphatase (SHIP). The novel system showed long-term therapeutic effects on the inhibition of restenosis when pcDNA3.1-iNOS was tethered on the stent. The primary objective was to assess the safety of esomeprazole 20 or 40 mg once daily in adolescents with clinically diagnosed gastroesophageal reflux disease (GERD). The receptor-mediated endocytosis of gold-labelled alpha 2-macroglobulin complexes with trypsin or methylamine (alpha 2M-T-Au or alpha 2M-MA-Au) was studied by electron microscopy in human skin fibroblasts. The patient recovered after tenormin 25 mg tablet side effects reduction in immunosuppression, with nutritional support and ganciclovir therapy. Typically, the celebrations involve intense socializing and considerable binge drinking.

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Thirty participants, 25 female and 5 male (mean age 38.2 years, range 25-63), received at least three (one set) as similar as possible Class II restorations of moderate size. Therapy of androgenetic sympatomatology with cyproterone acetate and ethinyl estradiol. Human Ia molecules carrying MT1 determinants: purification with a monoclonal antibody. However, qualitative and quantitative differences among studies were evident. Master equation calculations on a computational potential energy surface reveal that collisional stabilization at atmospheric pressure becomes important in the gas-phase ozonolysis of endocyclic alkenes for a carbon number between 8 and 15. Alterations of filaggrin metabolism have been recognized in a number of cost of pepcid ac pathological states of the skin and may be responsible for disturbed epidermal differentiation. Using fluorescent biosensors, we found that osmotic stress induced the formation of PI(4,5)P2 clusters that were spatially organized by eisosomes in both fission yeast and budding yeast cells. A Bovine Fibrinogen-Enriched Fraction as a Source of Peptides with in Vitro Renin and Angiotensin-I-Converting Enzyme Inhibitory Activities. Despite the accepted use of diuretics in acute HF syndromes, treatment patterns with diuretics vary widely, and there are no data from randomized studies on the benefit of diuretics on morbidity or mortality in patients hospitalized with acute HF syndromes.

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A case of beriberi heart failure in a chronic hemodialyzed patient is described. Inhibition effects of rhubarb ethanol extract on herpes simplex virus infection in vivo. Meniscal tears were also associated with greater tibial plateau bone area but not cartilage volume, providing support to the hypothesis that tibial plateau bone changes occur before significant pathological changes in cartilage. The LPA effect depends on increased proteasomal degradation of p53 and it results in a corresponding decrease in p53-mediated transcription. Calculation of uNa/uCr Ratio, fractional excretion of Na (FENa) and uNa/uK ratio as the hitherto best known parameters of prerenal Na depletion, respectively. p38 MAPK signal transduction pathway plays an important role in the development of UC. The purposes of this study were to evaluate the internal validity and interest reliability and to obtain normative data. A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population. All the R0 transgenic lines were highly resistant to these fungal pathogens compared to non-transgenic control plants. ECT is superior to pharmacotherapy for the short-term treatment of medication-resistant inpatients with bipolar depression.

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