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Phenergan (Promethazine)

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Phenergan is used in the treatment of nausea and vomiting related to certain conditions like before/after surgery or motion sickness. It may also be used to treat allergic conditions such as rash, itching, and runny nose.

Other names for this medication:
Abrozin, Admol, Basiprom, Biodol, Brumol, Calmkid, Ceedokid, Cofcodyl, Crophen, Enimol, Ethamol, Febrinil, Hyperex, Ibuprom, Kelvin, Kidkof, Kosgan, Lagesic, Lincotuss, Nimkair, Paracee, Paral, Paramax, Parapro, Petrox, Phenazine, Phenomet, Pizol, Primozyn, Procalm, Progene, Promacot, Promegan, Promethazine, Promethegan, Promit, Propar, Prophen, Prosed, Prosip, Prosym, Prozine, Pyrhist, Pyrivin, Romet, Symol, Synergan, Tymol, Zinmol

Similar Products:
Sovaldi, Cialis, Diamox, Abilify, Calan, Prilosec, Imitrex

Also known as: Promethazine


Cough/cold combinations are used mainly to relieve the cough due to colds, influenza, or hay fever. They are not to be used for the chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm (pronounced flem) with the cough.

Cough/cold combination products contain more than one ingredient. For example, some products may contain an antihistamine, a decongestant, and an analgesic, in addition to a medicine for coughing. If you are treating yourself, it is important to select a product that is best for your symptoms. Also, in general, it is best to buy a product that includes only those medicines you really need. If you have questions about which product to buy, check with your pharmacist.

Since different products contain ingredients that will have different precautions and side effects, it is important that you know the ingredients of the medicine you are taking. The different kinds of ingredients that may be found in cough/cold combinations include:

Antihistamines—Antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They also help relieve some symptoms of the common cold, such as sneezing and runny nose. They work by preventing the effects of a substance called histamine, which is produced by the body. Some examples of antihistamines contained in these combinations are:

Bromodiphenhydramine Brompheniramine Carbinoxamine Chlorpheniramine Dexchlorpheniramine Diphenhydramine Doxylamine Phenindamine Pheniramine Phenyltoloxamine Pyrilamine Promethazine Triprolidine

Decongestants—Decongestants produce a narrowing of blood vessels. This leads to clearing of nasal congestion. However, this effect may also increase blood pressure in patients who have high blood pressure. These include:

Ephedrine Phenylephrine Pseudoephedrine

Antitussives—Antitussives help relieve coughing and are some contain a narcotic. These antitussives act directly on the cough center in the brain. Narcotics may become habit-forming, causing mental or physical dependence, if used for a long time. Physical dependence may lead to withdrawal side effects when you stop taking the medicine.

Narcotic antitussives Codeine Dihydrocodeine Hydrocodone Hydromorphone

Non-narcotic antitussives Carbetapentane Caramiphen Dextromethorphan

Expectorants—Expectorants work by loosening the mucus or phlegm in the lungs. The main expectorant used in cough and cold medicines is guaifenesin. Other ingredients added as expectorants (for example, ammonium chloride, calcium iodide, iodinated glycerol, ipecac, potassium guaiacolsulfonate, potassium iodide, and sodium citrate) have not been proven to be effective. In general, the best thing you can do to loosen mucus or phlegm is to drink plenty of water.

Analgesics—Analgesics are used in these combination medicines to help relieve the aches and pain that may occur with the common cold. These include:

Acetaminophen Aspirin Other salicylates such as salicylamide and sodium salicylate

The use of too much acetaminophen and salicylates at the same time may cause kidney damage or cancer of the kidney or urinary bladder. This may occur if large amounts of both medicines are taken together for a long time. However, taking the recommended amounts of combination medicines that contain both acetaminophen and a salicylate for short periods of time has not been shown to cause these unwanted effects.

Anticholinergics—Anticholinergics, such as homatropine may help produce a drying effect in the nose and chest.

These cough and cold combinations are available both over-the-counter (OTC) and with your doctor's prescription.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .


For allergies (such as hay fever, rashes, and hives) Children 5-10 years: 1 tablet (25 mg) given at bedtime. Do not give more than 25 mg per day. Children over 10 years and adults (including the elderly): initially 1 tablet (25 mg) taken at bedtime. This may be increased to a maximum of 1 tablet (25 mg) twice a day if necessary. For treatment and prevention of feeling sick or being sick (such as travel sickness) Children 5-10 years: promethazine elixir or Promethazine 10 mg tablets should be given in this age group. Children over 10 years and adults (including the elderly): 1 tablet (25 mg) to be taken the night before the journey. This may be repeated after 6-8 hours if necessary. For short-term pediatric sedative and for short-term treatment of insomnia in adults Children 5-10 years: 1 tablet (25 mg) given at bedtime. Children over 10 years and adults (including the elderly): 1 or 2 tablets (25 mg - 50 mg) taken at bedtime.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include overactive reflexes, loss of coordination, severe drowsiness or weakness, fainting, dilated pupils, weak or shallow breathing, or seizure (convulsions).


Store at room temperature below 30 degrees C away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Phenergan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Very young children are usually more sensitive to the effects of this medicine. Before giving any of these combination medicines to a child, check the package label very carefully. Some of these medicines are too strong for use in children. If you are not certain whether a specific product can be given to a child, or if you have any questions about the amount to give, check with your health care professional, especially if it contains:

Antihistamines—Nightmares, unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in children taking antihistamines. Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Increases in blood pressure may be more likely to occur in children taking decongestants. Iodides (e.g., calcium iodide and iodinated glycerol)—These medicines pass into the breast milk and may cause unwanted effects, such as underactive thyroid, in the baby. Narcotic antitussives (e.g., codeine, dihydrocodeine, hydrocodone, and hydromorphone)—Breathing problems may be especially likely to occur in children younger than 2 years of age taking narcotic antitussives. Also, unusual excitement or restlessness may be more likely to occur in children receiving these medicines. Salicylates (e.g., aspirin)—Do not give medicines containing aspirin or other salicylates to a child or teenager with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your child's doctor. This is very important because salicylates may cause a serious illness called Reye's syndrome in children with fever caused by a virus infection, especially flu or chickenpox. Also, children may be more sensitive to the aspirin or other salicylates contained in some of these medicines, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

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