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Nimotop (Nimodipine)
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Nimotop

Nimotop is a medicine used to treat and prevent further damage to the brain after bleeding around the brain (subarachnoid hemorrhage or SAH). It is known as a calcium channel blocker and helps to improve blood flow to the brain and prevent changes in brain function.

Other names for this medication:
Modipin, Modipine, Nimocer, Nimodip, Nimodipine, Nimotide, Nymalize, Vasotop

Similar Products:
Aristocort, Actos, Flagyl, Mobic, Daklinza, Singulair, Famvir, Pepcid

Also known as: Nimodipine

Description

Nimodipine is used to treat symptoms resulting from a ruptured blood vessel in the brain (subarachnoid hemorrhage). It works by increasing the blood flow to injured brain tissue.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain nimodipine. It may not be specific to Nimotop. Please read with care.

Take this medicine exactly as directed even if you feel well and do not notice any symptoms. Do not take more of this medicine and do not take it more often than your doctor ordered. Do not miss any doses.

This medicine is usually given within 96 hours of having the condition. It is best to take this medicine at least 1 hour before or 2 hours after a meal.

If the capsule cannot be swallowed or if you are using this medicine with a nasogastric tube (NGT), you may put a hole in both ends of the capsule and remove its contents using a syringe. Use the syringe to give the medicine orally or through the NGT. Do not use it to give the medicine as an injection through the veins, muscles, or skin.

If you are using the oral liquid:

Measure your dose with a marked measuring spoon, oral syringe, or medicine cup. If the medicine is going to be given through a nasogastric or gastric tube, use the oral syringe that comes with the package to measure the dose. For each dose, refill the syringe with saline solution to flush any remaining medicine in the nasogastric tube into the stomach.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For subarachnoid hemorrhage: For oral dosage form (capsules): Adults—60 milligrams (mg) or two 30 mg capsules every 4 hours for 21 days. Children—Use and dose must be determined by your doctor. For oral dosage form (solution): Adults—20 milliliters (mL) (60 milligrams [mg]) every 4 hours for 21 consecutive days. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Nimotop and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Nimotop overdosage: pain of chest, fainting, abnormal slow or fast heartbeat, slurred speech, dyspnoea, feeling lightheaded, coma, confused mental state, weakness.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not refrigerate the oral liquid.

Detailed Nimotop dosage information

Side effects

The most common side effects associated with Nimotop are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nimodipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution in patients receiving nimodipine.

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The Human and Economic Burden of Difficult-to-Treat Gouty Arthritis. To reduce mortality and morbidity associated with these risk factors, periodic screening for carbohydrate and lipid abnormalities is recommended, with appropriate therapeutic interventions. IM practitioners favorably viewed their role in patient care, but this work existed within the context of challenges related to balancing supply and demand for services and to integrating an IM program into the established culture of a large hospital. Neonatal herpes simplex virus infections take one of three forms--disease localized to skin, eye, or mouth (SEM), encephalitis, or multiorgan disseminated disease. The main aim of performing a vascular anastomosis is to achieve maximal patency rates. A Tyrode solution containing a spasmolytic drug initiated the perfusion. However, predictions of public-health outcomes of vaccination will need to take account of variations in efficacy by transmission intensity and by time since vaccination. Both myo-inositol and choline at concentrations of 10 micrograms/ml were required for repression. Ectodermal dysplasia with total mandibular anodontia and partial extensive maxillary anodontia at the age of 15. Treatment of thumb soft-tissue defects using a bipedicle island flap of the index finger: anatomical basis and clinical application.

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To extend the life span of human osteoarthritic (OA) articular chondrocytes by introduction of the catalytic component of human telomerase while preserving the chondrocyte-specific phenotype. Herein, we report the direct observation of uMCs in vivo using double-transgenic C57BL/6J Mcpt5-Cre ROSA26-EYFP mice with high expression of enhanced yellow fluorescent protein in MC protease 5 (Cma1 (Mcpt5))-expressing cells by intravital two-photon microscopy. Reinnervation of the olfactory bulb after section of the olfactory nerve in monkey (Saimiri sciureus). In this randomised phase 2 study, patients aged 60 years or older with AML that had relapsed after a first complete remission lasting less than 12 months, or had achieved no previous complete remission, were randomly assigned (1:1) to receive as first salvage tosedostat 120 mg once daily for 6 months or 240 mg once daily for 2 months followed by 120 mg for 4 months. Collectively, these findings indicate that TN-C expression in the preimplantation period is under the control of progesterone, but not directly, possibly by the paracrine and autocrine intervention of IL-1 alpha secreted by epithelial cells and PGE(2) and PGF(2 alpha) secreted by stromal cells. Experiments 1 and 2 showed that the search efficiency was greatly improved when the target was distinctive with regard to structure, based on transparency. Sexual Fate Reprogramming in the Steroid-Induced Bi-Directional Sex Change in the Protogynous Orange-Spotted Grouper, Epinephelus coioides. No important differences were found in cross-shift effects of MWF between obstructed and non-obstructed workers. A 14-year-old boy with severe back pain for several years is described.

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These mice were treated with cyclophosphamide (CY) and irradiation (5 Gy x 2), followed by the transplantation of bones plus bone marrow cells from allogeneic normal C57BL/6 mice at the age of 12 weeks. Since then, there have been described less than a hundred of cases of this rare congenital malformation. These mu-chains were found only in the cytoplasm and were not secreted. Plastid isoprenoids are synthesized via the 2-C-methyl-D-erythritol 4-phosphate pathway. Human basophils respond to Ag-induced cross-linking of their high affinity IgE receptor, FcepsilonRI, by releasing histamine and other mediators from granules, producing IL-4 and other cytokines and, as shown in this study, by forming membrane ruffles and showing increased very late Ag-4 (VLA-4)-mediated adhesion to VCAM-1-expressing target cells. In the anesthetized rat intravenous captopril or sodium nitroprusside resulted in elevation of active renin only. Both the mean insulin peak and the mean insulin area were significantly more elevated in patients than in controls. In this debate article, our aim was to provide different perspectives on what is known about the colorectal healing process in relation to wound healing and AL. Overestimation of indocyanine green-derived plasma volume can occur in the presence of generalized capillary protein leakage.

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In conclusion, the intrinsic nerves of pancreatic and brain tissue fragments can survive after several weeks of transplantation into the anterior eye chamber of rats. Examining the experience of mental health nurses in court diversion schemes reveals the intensity of the experience of working in an inter-professional setting without the benefit of preparation or training, and without the frame of reference of a structured health environment. Planned third-party transfusions prior to first transplantations from liver related donors. These autologous tissue-engineered valves functioned up to 5 months and resembled normal heart valves in microstructure, mechanical properties, and extracellular matrix formation. Undetermined complexity of the pathophysiology of diabetic ketoacidosis in undernourished children. Dye-doped silicon oxide nanoparticles were assessed against a one-step luminescent cyanoacrylate.

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Finite element study showed that when the force was applied along the long axis of the implant, the maximum stress was located around the neck of the implant and the cortex bone received more stress than cancellous bone. Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles. The rate pH profile shows a gradual increase in the rate up to pH 6.2 (pHmax) followed by a decrease up to pH 9.0, depending upon the susceptibility of ionic species involved in the interaction. BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Lesions were generally described in corresponding reports as likely representing adenomas or hematomas based on CT findings. Subsequently, the young cell elongates, becomes somewhat deformed, and then emerges through a narrow aperture in the inflexible coats of the spore, finally rupturing the sporangium. Immunofluorescence patterns were found to be similar using antisera raised to thrombospondins purified either from bovine aortic endothelial cells or from human platelets. The antispasmodic effect develops slowly and can be removed only by repeated washing. Lung function in SCD children deteriorates with increasing age and the decline is more marked in younger children who have recently suffered ACS episodes.

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Docking Studies of Adenosine Analogues with NS5 Methyltransferase of Yellow Fever Virus. Magnetic resonance imaging is an important supplement to immunological and clinical data in differentiating multiple sclerosis from HAM/TSP. Most of the cells generated in the SVZ are neuronal precursors with progeny that migrate rostrally along a pathway known as the rostral migratory stream before they reach the main olfactory bulb (MOB) where they differentiate into local interneurons. A finite element analysis of stress distribution in the bone, around the implant supporting a mandibular overdenture with ball/o ring and magnetic attachment. Lynch syndrome from a surgeon perspective: retrospective study of clinical impact of mismatch repair protein expression analysis in colorectal cancer patients less than 50 years old. However, these patients are vulnerable to misunderstanding research purposes and procedures. We conducted an observational study on 110 consecutive parkinsonian patients scheduled for STN DBS surgery. Wave-beam coupling in quadratic nonlinear optical waveguides: effects of nonlinearly induced diffraction. Nine hundred and sixty-two adults receiving inpatient care at a private psychiatric hospital completed questionnaires at admission.

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Effect of haloperidol on development of amnesia in aggressive and submissive mice. Theoretically evaluated electrostatic potentials in close proximity to the ring carbon atoms reflect well both through-space and resonance effects and excellent correlation is established between the MEP values and substituent constants. Device physics and operation of lateral bulk heterojunction devices. It has been postulated that the early diagnosis of cardiac surgery-associated AKI using novel biomarkers will result in improved outcomes. After levaquin dose cap trypsin digestion of solubilized crystals, SDS-PAGE resolved a unique protease-resistant peptide of ca.

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Analysis of the sugar components of cross-reacting O-antigens of Salmonella, Arizona and Escherichia. Tests included Hybrid Capture 2, Abbott RealTime PCR, BD HPV, Cobas 4800, PreTect HPV-Proofer, APTIMA and p16(INK4a). Interaction of dopamine and haloperidol with O2 and CO2 chemoreception in carotid body. An analysis of research and clinical practice in neonatal pain management. Using immunocytochemical techniques at light and electron microscopy, we analysed the distribution of phosphorylated c-Myc in actively proliferating human HeLa cells. The observed variation in the activity ratio of plutonium-238 to plutonium-239 plus plutonium-240 in rainwater in Japan over the period from 1961 through 1968 seems to indicate that the influence of the plutonium-238 released by the burnup of the nuclear auxiliary power generator (SNAP-9A) became noticeable within about 6 months and that variation in the isotope ratio with time is affected by nuclear debris produced in the latest explosions as well as by the plutonium-238 released from the SNAP-9A generator. Most recently, checkpoint inhibitors have demonstrated a modest degree of activity in a subset of TNBC.

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Octreotide relaxes the hypertensive sphincter of Oddi: pathophysiological and therapeutic implications. Medical advances, such as antiplatelet and antithrombin agents and growing databases on interventional outcomes have created a new world of therapeutic options for the spectrum of ischemic heart disease. Two of the resistant isolates were heterozygous, containing at least one mutant copy and one wild-type copy of the can i drink alcohol on lamisil 23S rRNA gene. In an attempt to bridge this knowledge gap between cancer genetic and molecular profiling and clinically useful information, an individualized systems medicine program has been established at the Institute for Molecular Medicine Finland (FIMM), University of Helsinki, and the Helsinki University Hospital. Estrogen receptors were positive and immunohistochemistry pointed to a breast origin. The requirement for PPi in this pathway can be satisfied only to a small extent by biosynthetic reactions, in contrast to what is generally assumed for a PPi-dependent glycolysis in anaerobic heterotrophs. The application of proton transfer reaction-mass spectrometry (PTR-MS) to the monitoring and analysis of volatile organic compounds in the atmosphere. The Multinational Association for Supportive Care in Cancer risk index score developed, through a multinational collaboration, was published in 2000 with the aim to identify patients with chemotherapy-induced febrile neutropenia at low risk of serious medical complication development.

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Numerical simulation and experiment on split tungsten carbide cylinder of high pressure apparatus. The crystal structure of PFDH has been solved by the multiwavelength anomalous diffraction method using intrinsic zinc ions and has been refined at a 1.65 A resolution. This systematic review failed to demonstrate obvious advantage in preserving duodenal passage after total gastrectomy amoxil chewable dosing . Basal plasma AVP concentrations were significantly elevated in Crhr1-/- mice. Body condition effects in American kestrels fed selenomethionine. These issues are dealt with in this COA presidential address given at the COA annual general meeting in June 2001. They also represent privileged models in medicine, because well characterized monogenic inherited diseases can in some instances be viewed as good targets for gene therapy as shown here for severe combined immunodeficiency (SCID).

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Smoking Status Influences Clinical Outcome in Collagenous Colitis. Measuring improvements in upgraded alternating-pressure air mattresses. While some macrophage phenotypes (M1) exhibit anti-tumor activity, distinct phenotypes (M2) may contribute to malignant progression and metastasis. This study examines the effects of repeated administration of the selective serotonin reuptake inhibitors (SSRIs), fluoxetine and citalopram (10 mg/kg, i.p.), on immunoreactivity in C57BL/6 mice. Low density lipoprotein (LDL) particles are the major cholesterol carriers in circulation and their physiological function is to carry cholesterol to the cells. An objective score was created for every electrode point that was correlated with MRI and PET abnormality at the point.

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In particular, dosing unpredictably relative to motility phase means the gastrointestinal environment is a random variable within a defined range. By using specific PAI-1 mutants with either VN binding or plasminogen activator (PA) inhibiting activities ablated, we have shown that the PAI-1-mediated interference with insulin signaling occurs through its direct interaction with VN, and not through its PA neutralizing activity. To determine the in vivo efficacy and safety of a retroviral vector bearing an antiproliferative dominant negative mutant cyclin G1 (dnG1) construct, when used for the prevention of corneal haze after phototherapeutic keratectomy (PTK). Oral vancomycin treatment after disease induction significantly decreased clinical symptoms of AIA. Using real-time quantitative PCR and Western blotting, SCIRR39 expression was detected in oligodendrocyte precursor cells (OPCs) and oligodendrocytes. This data suggests an increased glycation of both plasma proteins and glycated hemoglobin in acute myocardial patients, which might be independent of prevailing glucose concentration. Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis. Work now is in progress on further optimisation of the vaccine and its large-scale manufacture at industrial sumycin drug class level. Dyeing kinetics data at different temperatures indicate that Direct Pink 12B up-take on the modified cotton fabrics fitted to pseudo second-order kinetic model. Small group of patients, lack of different types of treatment as control groups.

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