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Lunesta (Eszopiclone)

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Lunesta is a sedative medication. It affects chemicals in human brain that may become unbalanced and cause sleep problems (insomnia). Lunesta is used to treat insomnia: it causes relaxation to help you fall asleep and stay asleep. EsLunesta may also be used for purposes other than those listed here.

Other names for this medication:
Bexomer, Eszopiclone, Fulnite, Zolnite, Zopimin, Zopipure

Similar Products:
Combivent, Zyprexa, Caverta, Aristocort, Dramamine, Zofran, Maxalt, Kemadrin

Also known as: Eszopiclone


Lunesta along with other Z-drugs are the most commonly prescribed sedative hypnotics in the United States. Eszopiclone is not marketed in the European Union following a 2009 decision by the EMA denying it new active substance status, in which it ruled that eszopiclone was too similar to zopiclone to be considered a new patentable product. Eszopiclone is now available in a generic form in the United States as of May 2014. On May 15, 2014, the USFDA asked that the starting dose of Lunesta be lowered from 2 milligrams to 1 milligram after it was observed in a study that even 8 hours after taking the drug at night, some patients were not able to cope with their next-day activities like driving and other activities that require full alertness. It works by interacting with the GABA receptors.

Lunesta is slightly effective in the treatment of insomnia where difficulty in falling asleep is the primary complaint. Kirsch et al. found the benefit over placebo to be of questionable clinical significance. Although the drug effect and the placebo response were rather small and of questionable clinical importance, the two together produce a reasonably large clinical response. It is not recommended for chronic use in the elderly.


Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take Lunesta only if you are able to get a full night's sleep before you must be active again. Never take this medication during your normal waking hours, unless you have at least 8 hours to dedicate to sleeping.

Take Lunesta with a full glass of water.

Avoid taking Lunesta within 1 hour after eating a high-fat or heavy meal. This will make it harder for your body to absorb the medication.

Lunesta is for short-term use only. Tell your doctor if your insomnia symptoms do not improve, or if they get worse after using this medication for 7 to 10 nights in a row. Do not take Lunesta for longer than 2 weeks without your doctor's advice.

You may have withdrawal symptoms if you stop taking Lunesta after taking it over several days in a row. Do not stop taking Lunesta suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.


In clinical trials with Lunesta, one case of overdose with up to 36 mg of Lunesta was reported in which the subject fully recovered. Since commercial marketing began, spontaneous cases of Lunesta overdoses up to 270 mg (90 times the maximum recommended dose of Lunesta) have been reported, in which patients have recovered. Fatalities related to Lunesta overdoses were reported only in combination with other CNS drugs or alcohol.

exaggerations of the pharmacological effects noted in preclinical testing. Impairment of consciousness ranging from somnolence to coma has been described. Rare individual instances of fatal outcomes following overdose with racemic zopiclone have been reported in European postmarketing reports, most often associated with overdose with other CNS-depressant agents.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Flumazenil may be useful. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. The value of dialysis in the treatment of overdosage has not been determined.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Do not share this medication with others. It is against the law.

Side effects

The most common side effects associated with Lunesta are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before taking Lunesta, tell your doctor if you are taking any of the following drugs: rifampin (Rifadin, Rifater, Rifamate, Rimactane); ketoconazole (Nizoral); or antidepressants, narcotic pain medications, muscle relaxers, seizure medications, or anti-anxiety medications.

This list is not complete an there may be other drugs that can interact with Lunesta. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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The molecular regulation of the MDO Shh expression and the potential role of Shh in development of the habenula remain largely unclear. All the peripheral pulses were normal, except the right radial pulse which was feeble. Three-dimensional volumetric quantification of fat loss following cryolipolysis. Video game play, attention, and learning: how to shape the development of attention and influence learning?. These results further point to glutamate as an intracellular messenger playing a key role in the control of insulin exocytosis. To investigate tobacco-related knowledge, attitudes and analyze related factors among the college students in Guangzhou. Selenoprotein P (SeP) has recently been reported as a novel hepatokine that regulates insulin resistance and systemic energy metabolism in rodents and humans. In the investigation of patients with solid tumours bone marrow biopsy may detect metastases in 20 per cent (bronchus), 35 per cent (prostate), 40 per cent (breast), to 80 per cent (unknown primaries) of the patients. The present analysis suggests that isolation of arrhythmogenic veins had a comparable long-term success rate, shorter procedure time, fluoroscopic time, and fewer adverse events than the empiric isolation of all PVs. Sex-related analysis of short- and long-term clinical outcomes and bleeding among patients treated with primary percutaneous coronary intervention: an evaluation of the RISK-PCI data.

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