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Losartanum (Losartan)
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Losartanum

Losartanum belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Losartanum prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Losartanum slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
Angioten, Angizaar, Cozaarex, Forzaar, Klosartan, Lakea, Loctenk, Lortaan, Losap, Losar, Losarb, Losartan, Losartanum, Losium, Lostan, Lotan, Omnitan, Ostan, Ozarium, Portiron, Prosan, Rasoltan, Sarilen, Sarlo, Sartaxal, Sarvastan, Sarve, Temisartan, Tensartan, Tensiohess

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Also known as: Losartan

Description

Losartanum (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Losartanum is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Losartanum is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Losartanum 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Losartanum 25 mg, Losartanum 50 mg, and Losartanum 100 mg may also contain carnauba wax.

Dosage

Take Losartanum tablets orally with or without food. Do not crush or chew it. Take Losartanum once or twice a day at the same time. If you want to achieve most effective results do not stop taking Losartanum suddenly.

Overdose

If you overdose Losartanum and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Losartanum overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Losartanum are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Drinking alcohol can further lower your blood pressure and may increase certain side effects of Losartanum.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

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