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Lodine (Etodolac)

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Lodine is a prescription medicine used to treat the symptoms of mild-to-moderate pain and inflammation associated with arthritis. Lodine may be used alone or with other medications. Lodine belongs to a class of drugs called nonsteroidal anti-inflammatory drug(NSAID).

Other names for this medication:
Etios, Etobest, Etodolac, Etofree, Etogesic, Etomax, Etoron, Etosafe, Etova, Etura, Freeup, Penalgon, Proxym, Setolac, Toldin

Similar Products:
Desyrel, Paxil, Alprostadil, Cozaar, Myambutol, Bystolic, Inderal, Colospa, Hytrin

Also known as: Etodolac


Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (eg, osteoarthritis and rheumatoid arthritis), including inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will help you only as long as you continue to take it.

This medicine is available only with your doctor's prescription.


Usual Adult Dose of Lodine for Osteoarthritis:

Immediate Release: -Initial dose: 300 mg orally 2 to 3 times a day or 400 mg to 500 mg orally twice a day -Maintenance dose: A lower dose of 600 mg/day may suffice for long-term use -Maximum dose: 1000 mg/day Extended Release: 400 mg to 1000 mg orally once a day Comments: -Therapeutic response can be seen within 1 week of therapy, however, is most often observed by 2 weeks; doses should be adjusted accordingly after satisfactory response is achieved. Uses: For acute and long-term use in the management of signs and symptoms of osteoarthritis and rheumatoid arthritis

Usual Adult Dose of Lodine for Rheumatoid Arthritis:

Immediate Release: -Initial dose: 300 mg orally 2 to 3 times a day or 400 mg to 500 mg orally twice a day -Maintenance dose: A lower dose of 600 mg/day may suffice for long-term use -Maximum dose: 1000 mg/day Extended Release: 400 mg to 1000 mg orally once a day Comments: -Therapeutic response can be seen within 1 week of therapy, however, is most often observed by 2 weeks; doses should be adjusted accordingly after satisfactory response is achieved. Uses: For acute and long-term use in the management of signs and symptoms of osteoarthritis and rheumatoid arthritis

Usual Adult Dose of Lodine for Pain:

Immediate Release: 200 mg to 400 mg orally every 6 to 8 hours -Maximum dose: 1000 mg/day Use: For the management of acute pain

Usual Pediatric Dose of Lodine for Juvenile Rheumatoid Arthritis:

Extended Release: 6 to 16 years: 20 to 30 kg: 400 mg orally once a day 31 to 45 kg: 600 mg orally once a day 40 to 60 kg: 480 mg orally once a day Greater than 60 kg: 1000 mg orally once a day 17 to 18 years: 400 mg to 1000 mg orally once a day Use: For the relief of signs and symptoms of juvenile rheumatoid arthritis

Detailed Lodine dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, vomiting, stomach pain, or stomach bleeding.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Basal and activation-dependent ligand binding by alpha(IIb)beta(3) and alpha(V)beta(3) was unaffected. Evaluation of efficacy of the managed population transmigration from zone of obligate (compulsory) resettlement as a measure of civil protection after the Chernobyl NPP accident from the perspective of radiation biology. Whole cell patch-clamp recordings indicated that voltage gated potassium channel currents I(Kv) and I(K(N)) were decreased in PAMCs from CH rats with a hyper sensitivity of I(K(N)) to 4-AP. Unusual substrate specificity of the peptidoglycan MurE ligase from Erysipelothrix rhusiopathiae. Rates of nicotine dependence vary in different sociodemographic groups in the population. Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3. The immunofluorescence reaction was competitively inhibited by MCA-F fractions that induced specific immunoprotection: crude 3 M KCl extract, isoelectrically focused TSTA (fraction 15), and intact irradiated MCA-F cells. The effect of erythropoietin on colonial growth of erythroid precursor cells in vitro. Adh-negative mutants: detection of an altered tryptic peptide in a mutant enzyme of Drosophila.

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Homologous chromosome associations and nuclear order in meiotic and mitotically dividing cells of budding yeast. ESSENTIALS: We developed a new algorithm to optimize vitamin K antagonist dose finding. On the basis of GB/T 1.1-2009, some preliminary suggestions were accordingly proposed. Intensification of skin inflammation in the pyrexal test following coli-endotoxin (lipopolysaccharide)i.v. Now, a novel inducible conditional knockout model of the mineralocorticoid receptor (MR) in vascular smooth muscle cells (VSMCs) brings out understanding further. Up-to-date improvements in inorganic ring systems as anticancer agents. The present study consisted of a retrospective analysis of clinical and non-clinical available information about 186 patients suffering from ED consecutively admitted into the Villa Maria Luigia Private Hospital (Parma, Italy) in a three-year period (01/01/2006 - 31/12/2009). Physicians should be aware of the common dangers and overuse syndromes in this highly acrobatic gymnastic discipline. The prevalence of allergic diseases has increased particularly over the past 30-40 years.

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A pathophysiological role of gut hormones has been established only for rare conditions This is because the clinical significance of the gut hormones is difficult to evaluate. The body composition data show that the Malian girls have lower body fat than reference girls. This method was used to show that the distinctive microbial community structure in tea orchard soils was not, however, due to differences in pH alone. In this study we analyzed whether cytosine methylation of specific sequences plays a functional role during DNA rearrangement. Canaloplasty could provide better localization benefit and subjective improvement in spatial sensation to unilateral CAA patients. The recombinant PA-D4 exhibits CD and NMR spectra that suggest that it is folded and amenable for biophysical studies. Treatment with immune rabbit serum or immune rabbit immunoglobulin G significantly (P less than 0.001) increased phagocytosis of E. The dynamics of deposition are found to vary for different ink-substrate systems, and the change in deposition rate over the course of an experiment limits our ability to quantify the ink-transfer dynamics in terms of liquid properties and substrate wettability. The effects of dopaminergic and opioidergic drugs on sexual incentive motivation were evaluated in sexually inexperienced male rats subjected to a choice procedure. Cutaneous gene therapy offers unique opportunities and limitations in the use of viral vectors for corrective gene transfer.

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The detection of an identical mutation in the AGXT gene suggests that specific genetic screening for this mutation may be useful when considering the diagnosis of primary hyperoxaluria type1. Aided by SIMION 7.0, the electric field distribution at both sides of ion shutter was simulated and compared. Event-related fMRI, while avoiding stimulus order predictability, is in theory statistically less powerful than block designs. Cardiovascular magnetic resonance (CMR) imaging was performed on day five and confirmed severely depressed left ventricular systolic function with typical apical ballooning. This condition leads to the progressive impairment of central visual acuity. A randomised clinical trial on the efficacy of oxytetracycline dose through water medication of nursery pigs on diarrhoea, faecal shedding of Lawsonia intracellularis and average daily weight gain. Also, 23 moderately to severely atypical and 25 severely atypical nevi from consecutive submissions were added for statistical reasons.

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Ribonucleotide reductase of Pithomyces chartarum: requirement for B12 coenzyme. Perinatal nutrition in maternal mental health and child development: Birth of a pregnancy cohort. TIPS is used for the control of acute variceal bleeding and for the prevention of vericeal rebleeding when pharmacologic therapy and endoscopic therapy have failed. We propose that the dephosphorylation of HAS enzymes targeted by PP2B augments HA production, while their phosphorylation by the activity of MAPK pathway reduces HA synthesis. Gas6 up-regulated the phosphorylation of cellular proteins including p42/p44 mitogen-activated protein kinase (MAPK), but not p38 or c-Jun N-terminal kinase MAPK, and increased the kinase activity of immunoprecipitated Tyro 3 in isolated osteoclasts. Effect of acupuncture on knee function in advanced osteoarthritis of the knee: a prospective, non-randomised controlled study. These findings provide new insight into the molecular characteristics and functions of bovine HGF. Cross-sectional assessments of visual function and retrospective collection of fall data. Decades ago, studies speculated that elements of an autoimmune response were associated with the development of hypertension based, in part, on the presence of circulating autoantibodies in hypertensive patients.

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Flow cytometric analysis of costimulatory molecules and MHC class II showed that DC maturation was stimulated most by ODN-1826, whereas TNF-alpha had an intermediate effect. Immunofluorescent localization of rubella virus in the lens, retina and heart of congenital rubella-infected rats. We present our experience in 850 consecutive patients who had a laparotomy through a lateral paramedian incision during the period 1977-1981. Renal artery stenosis, diagnosed in 17 kidneys (4.9 per cent), resulted from surgical technique or rejection and was associated with hypertension in all cases. Regulatory role of carbon dioxide in malate dehydrogenase reaction. Acid production by dental plaque after sugar and sugar substitute intake. Polycystic ovary syndrome: implications for the advanced practice nurse in primary care. Competition of antigens as influenced by spacing of heterologous antigen injections.

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Trichophyton tonsurans tinea capitis and tinea corporis: treatment and follow-up of four affected family members. The short courses had the advantage of improved gastrointestinal tolerance compared with longer durations of treatment. According to distinct light-matter interaction processes, the total torque is decomposed into scattering and extinction torques. The purpose of this study was to find whether Cardiac Magnetic Resonance (CMR) could assess the myocardial interstitium in patients suffering from systemic amyloidosis with normal left ventricular ejection fraction. Over the past 25 years this emphasis has remained, but many NBTs have gone on to provide help to people with other problems. The results of this study provide direct evidence for the implication of Tec family kinases in the responses of human neutrophils to chemotactic factors. Evaluation of ORF-1658, a new formulation for sequential oral contraceptive therapy. Age and fat fraction have small measurable effects on quantitative DCE-MRI parameters in bone marrow. The purpose of this study was to investigate associations between voice quality and swallowing function in patients treated for oral or oropharyngeal cancer.

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