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Lamictal (Lamotrigine)

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Lamictal is a mood stabilizer medication that works in the brain. It is approved for the treatment of bipolar disorder (also known as manic depression) and certain types of seizure disorders. Bipolar disorder involves episodes of depression and/or mania.

Other names for this medication:
Epitic, Eptic, Lamepil, Lamepri, Lametec, Lamidus, Lamitor, Lamogin, Lamonex, Lamorig, Lamosyn, Lamotrigine, Laogine, Lemit, Lemogen, Lemoring, Lyzin

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Also known as: Lamotrigine


Generic Lamictal is a medication indicated for adjunctive therapy for infancy with the following types of seizure such as partial seizures, primary generalized tonic-clonic seizures, generalized seizures of Lennox-Gastaut syndrome; monotherapy for adult patients with partial seizures who are also receiving their treatment with carbamazepine, phenytoin, phenobarbital,primidone and valproate; bipolar disorder treatment for adults. Generic Lamictal helps to control mood episodes (depression, mania, hypomania and mixed episodes). Generic Lamictal remains an effect of sodium channels. Generic Lamictal keeps off sodium channels thereby stabilizing nervous membranes and hereupon modulate presynaptic transmitter release of excitatory amino acids. Lamictal is also known as Lamotrigine, Lametec. Generic name of Generic Lamictal is Lamotrigine. Brand name of Generic Lamictal is Lamictal.


Take it orally. Generic Lamictal can be used by children and adults. If you want to achieve most effective results do not stop taking Generic Lamictal suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include blurred vision, problems with coordination, increased seizures, feeling light-headed, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Lamictal CD dosage information

Side effects

The most common side effects associated with Lamictal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Lamictal ODT if you are allergic to it.

Lamictal ODT may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote).

Tell your doctor if you have ever had:

a rash or allergic reaction after taking another seizure medication; kidney or liver disease; heart problems such as heart block or irregular heartbeats; depression, suicidal thoughts or actions; or meningitis (inflammation of the tissue that covers the brain and spinal cord) after taking Lamictal ODT.

Some people have thoughts about suicide while taking Lamictal ODT. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lamotrigine on the baby.

Birth control pills can make Lamictal ODT less effective, resulting in increased seizures. Tell your doctor if you start or stop using birth control pills. Your this medicine dose may need to be changed.

It may not be safe to breastfeed while using Lamictal ODT. Ask your doctor about any risk.

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A capillary enzyme immunoassay kit for the detection of snake venom in specimens from envenomed patients has now been in use for two summer periods. The different emphases in each module, provided by experienced instructors, enabled the students to be more aware of their role in pediatric medication safety. Macrophage response to peripheral nerve injury: the quantitative contribution of resident and hematogenous macrophages. Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development. Altering litter gender composition affects maternal behavior and DNA methylation levels of another gene in hippocampus and nucleus accumbens (NAc). Special emphasis was placed on the heat stability and cross-reactivity of these allergens. The authors evaluated some soil environmental factors that might affect its nematicidal activity. When nitrogen was limiting in the medium, phenol induced higher oxygen uptake rates, whereas catechol was independent of the nitrogen levels. A pelvic examination revealed a cauliflower-like, fungating mass about 4 cm in diameter located in the anterior vaginal vault.

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RT-PCR, immunohistochemistry and/or Western blot were used in 54 cases of lung cancer tissues and corresponding normal lung tissues. Chronic alpha-tocopherol supplementation in rats does not ameliorate either chronic or acute alcohol-induced changes in muscle protein metabolism. The sonographic ovarian imaging varied from a polycystic- to an ovarian hyperstimulation-like pattern during the evolution of the tumour. We present a case that illustrates this diagnostic difficulty along with the principles of treating pneumocephalus with Ventriculoperitoneal (VP) shunt in situ. ADI628 had roughly dose-linear increases in blood concentrations with moderate variability after single and multiple administration in healthy subjects. Unspecific inflammatory stimuli have been shown to induce pulmonary heme oxygenase possibly leading to increased pulmonary carbon monoxide production and elevated arterial COHb. We analyzed 353 eyes, including 67 nonmyopic preperimetric glaucomatous eyes, 182 myopic healthy eyes, and 104 myopic preperimetric glaucomatous eyes.

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However, this tumor did not display altered transcription or protein levels of HRPT2 nor cyclin compared with the other OF. After restorative proctocolectomy in 1989, and extensive small bowel resection for desmoid disease in 1991, regular surveillance duodenoscopies, including three to nine biopsies (mean, 4.8) were performed annually or biannually. Respiration of isolated mitochondria from mitochondrial mutants is resistant to myxothiazol. Although ADR mitochondria experience a decrease in ETC capacity with age, they succeed to maintain highly efficient and well-coupled function compared to fully fed controls. Echographic follow up of malignant melanoma of the choroid after brachytherapy with iodine-125. Absorption of chlorogenic acid and caffeic acid in rats after oral administration.

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In these latter cases ABMS types 4 and 5 predominated, whereas in the light and focal tubular lesions ABMS type 2 did. By contrast, the majority of intermolecular interactions involve contacts to backbone phosphates in the published structure of streptomycin bound to the 16S rRNA. Microsurgical subinguinal varicocelectomy is one of the best treatment modalities for varicoceles. Besides, the relationship of haplotypes between the polymorphisms with cervical cancer susceptibility was analyzed. AT CMAP amplitude may serve as a useful outcome measure for physiological changes in natural history studies and clinical trials for patients with CMT1A. Although several agenices are charged with the planning role, the Health Systems Agency (HSA) has emerged as the major planning unit. To our surprise, we found that neither oncogene action nor the cell cycle altered topo IIalpha protein levels in actively cycling cells. The demonstration of Plasmodium berghei sporozoites in rat hepatocytes one hour after inoculation. The results suggest that AXRF reduced the levels of circulating BAs which slowed down the digestion of TAG and absorption of free fatty acids, with consequent reduction in blood TAG. There were significantly positive correlations among leaf C:N, C:P, and N:P.

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An essential difference between the two functions is that the characteristic function can accommodate a detection limit. Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells. Dependent on the strategy of stem cell tracking, the phagocytosis of implanted cells as observed in this study, might also impede the interpretation of results. mRNA expression of type I and type II receptors for activin, transforming growth factor-beta, and bone morphogenetic protein in the murine erythroleukemic cell line, F5-5.fl. Vital capacity determinants were taken near the beginning and end of two 17-week semesters. The levels of ALP activity and OCN content in the composites were significantly higher in the LIPUS group than in the control group. With increasing age, statistically significant rises in plasma PI exposure, but not NNRTI exposure, were observed. Sleep disturbances are extremely prevalent in children with neurodevelopmental disorders compared to typically developing children. In this work, we describe the development and application in Escherichia coli strains of an interference-independent assay based on engineered selectable CRISPR-spacer integration reporter plasmids.

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Evaluation of all potential sulfur sources is necessary to estimate total dietary sulfur concentration, which can lead to prevention strategies. Isolation and sequence analysis of the trpBA gene cluster, encoding tryptophan synthase, from Azospirillum brasilense. Exhaled breath condensate eicosanoid levels in asthma: still questioned. Retrospective analysis of 186 cases of the community mental health service in Dortmund (Germany) presenting with a destitute situation of the domestic environment as core problem. The key to this high regioselectivity is the appropriate choice of a phosphinoyl directing group and a pyridine-type ligand in the presence of Pd(OAc)2 catalyst. These data suggest that Shh could induce redifferentiation of dedifferentiated chondrocytes through up-regulating Shh signaling pathway, and have considerable therapeutic potential in cartilage repair. Adjuvant therapy in the past 10 years has gone from experimental to clinical practice for women who are premenopausal. As a simple, generally inexpensive intervention, providers should consider implementing preoperative vaginal cleansing with povidone-iodine before performing cesarean deliveries. Multiple cues for quantification in infancy: is number one of them?. Ascertaining their clinical role remains an important goal for the GWAS community with international consortia now established, pooling efforts and resources to move this field forward.

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Layer plate CAS assay for the quantitation of siderophore production and determination of exudation patterns for fungi. The aim of this study was to determine the amount of intravenous cytotoxic drug wastes, their collection and disposal status in chemotherapy wards, and to compare the current status with standard guidelines in Shiraz, Iran. The plenty of milk available to the young for a period of five days positively influenced the body weight of the rats in group P2, whereas in the remaining groups the total weight showed no significant change in comparison with normally fed animals. A single gene that promotes interaction of a phytopathogenic bacterium with its insect vector, Drosophila melanogaster. Knowledge and vaccination gaps before the 2015/2016 influenza seasons. To determine the no-observed-adverse-effect level (NOAEL) of exposure and target organs of neem oil for establishing safety criteria for human exposure, the subchronic toxicity study with neem oil in mice was evaluated. It is possible that, in patients with nasal polyps, asthma, and COPD, the need to breathe through the mouth rather than the nose facilitates the sting by sandflies. Baseline survey questionnaires collected sociodemographic and health information. Generational differences in the age at diagnosis with Ibd: genetic anticipation, bias, or temporal effects.

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NE is not required for mouse neutrophil NET production in vitro with non-infectious stimuli. Short-term exposure of cartilage to blood results in chondrocyte apoptosis. Groups II and III muscle afferents, low threshold skin and low threshold joint afferents projected to the upper bank of the suprasylvian fold. A general pediatrics ward at The Hospital for Sick Children in Toronto, Ontario, Canada, a 320-bed, tertiary-care pediatric institution. In this pilot study, we identified three serum biomarkers indicative of inflammation to be associated with spontaneous preterm birth among obese women: sVEGFR3, sIL-2RA and sTNFR1. The timing of carotid endarterectomy (CEA) after thrombolysis is still a matter of debate. Autoanalyzer quantification of anti-D: results of an international proficiency survey. Furthermore, cells additionally defective in IRF-7 expression totally fail to induce these genes in response to infections by any of the virus types tested. How they interact with the innate and adaptive immune systems is unknown.

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On the effect of ADH-stimulating drugs on the neurosecretory system. In women, MR and GR mRNA concentrations were markedly lower in hippocampal tissue than in frontal and temporal lobe cortex tissue. The MAPK kinase (MEK) signaling pathway could be a target for novel antidepressant drugs and an important pathway involved in neuronal plasticity. However, no study has yet been published to describe the technical limitations, intraoperative complications, and surgical bailout strategies for this new technology. Motorbike accidents are a major cause of severe traumatic brain injury. The preoperative differential diagnosis for the condition present on the tooth included a vertical fracture and a combined periodontal-endodontic lesion.

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Further studies on the immunogenic properties of photooxidized Formosan snake venoms, with special reference to a trial preparation of polyvalent antivenin using photooxidized multiple venom antigens--second report. Comparison of short- with long-term regeneration results after digital nerve reconstruction with muscle-in-vein conduits. Biotin induces tetramerization of a recombinant monomeric avidin. We compared functional and structural changes in the hands, in particular the prevalence of carpal tunnel syndrome, in 56 paraplegic patients who had been wheelchair dependent for over 25 years with a group of able-bodied volunteers (with matching criteria for gender and age). They were enveloped with a cytoplasmic layer of reticular cells and consisted of elongated smooth muscle cells, fascicles of collagenous fibrils and elastic fibers. We therefore aimed to evaluate whether rs7968585 predicts separate clinical outcomes such as T2D, MI, cancer, and mortality in a community-based Norwegian population. The DNA methylation pattern is reprogrammed in embryonic germ cells. We review the approach to the patient with valvular heart disease, and the sources of early and late postoperative pathology with emphasis on complications of the prostheses used. Differentiation of medical research from medical technology is essential in this confrontation.

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To examine whether overexpression of DHAR in plants would increase the level of ascorbic acid through improved ascorbate recycling, a DHAR cDNA from wheat was isolated and expressed in tobacco and maize, where DHAR expression was increased up to 32- and 100-fold, respectively. The plasma concentration of this protein was found to be lower in thirteen children suffering from protein-energy malnutrition compared with age-matched healthy preschool children. In recent years, immunodeficiency disorders have been recognized. Although several molecules that inhibit histone deacetylase are undergoing preclinical development, butyric acid derivatives have undergone clinical investigation for several years, initially for non-malignant indications and more recently for the treatment of cancer. Human thyroid NE cells can produce human insulin, fractions of which are both secreted and retained in secretory granules. The lethal mechanism is hypothesized to center on a unique role for free hemoglobin in inhibiting peritoneal absorption and stimulating an glimepiride drug interactions intraperitoneal exudate which supports luxuriant bacterial growth. Taken together, the results reveal that the subcellular localization of Dax-1 is influenced by the presence of Ad4BP/SF-1, and that two regions of Dax-1 have important roles for this process. Classification of hybridomas to respiratory syncytial virus glycoproteins. A simple method of detecting the anti-inflammatory action of topical dry eye treatments.

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Conversion of human colonic adenoma cells to adenocarcinoma cells through inflammation in nude mice. Use of peptide nucleic acid probes for detecting DNA single-base mutations by capillary electrophoresis. We conclude that the changes in expression patterns of CDK-phosphorylated histone H1 in the spectrum of gynecologic squamous intraepithelial lesions are similar to staining patterns obtained with the proliferation probe MIB-1. Doppler signals for each agent recorded on video and digitally on optical disk were assessed for signal quality, estimated RV pressure, interobserver and intraobserver variation, and longevity of signal. Molecular methods have confirmed their potential for epidemiological research and for the detection of resistant H. Surveys were administered to 38 SEAD participants over two program cycles. Homoharringtonine (HHT) has antileukemic activity in patients with Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML). Activation of the transcriptional regulatory factor nuclear factor-kappaB after hemorrhage or endotoxemia was diminished in the lungs of neutropenic mice compared with nonneutropenic controls. In addition to advance care planning, because patients with ESRD have a high symptom burden, this needs to be addressed. Normal embryos were selected for embryo transfer after fluorescence in-situ hybridziation in biopsied blastomere.

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In depressive disorder baseline values correlated significantly for salivary cortisol and plasma cortisol, salivary cortisol and plasma corticotropin-releasing factor and plasma corticotropin and beta-endorphin. Taken together, we propose miR-1290 as the new oncomiR involved in LSCC pathogenesis. Immunohistochemical analysis of O(6)-methylguanine-DNA methyltransferase in human melanoma in comparison with skin squamous cell carcinoma. On-going studies evaluating the relationship between body lead stores and both cognitive and renal impairment, as well as the potential modifying effect of bone resorption, will help determine whether bone resorption should be retarded specifically to preserve organ function. It looks principally at the albendazole 200 mg dosage various ways in which it may present, the limited knowledge of its pathophysiology, and the role of carotid sinus massage in the investigation of carotid sinus syndrome. Hypoxic tachypnea can be partly or completely reversed by injection of dopa or xanthines such as caffeine or aminophylline. This was compared with the assessments of clinical dietitians and a physician. Intravitreal bevacizumab injection is very effective in reducing macular thickness as well in improving visual acuity in all types of retinal vein occlusion. Maternal hypothyroxinemia in early pregnancy is often associated with irreversible effects on neuropsychomotor development. Simvastatin effects on a human lung carcinoma and cholesterol homeostasis of host and non-host mice.

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Activities of garenoxacin (BMS-284756) and other agents against anaerobic clinical isolates. In this work, some implications of a recent model for the mechanical behavior of biological membranes (Deseri et al. Through the lens of recent research in marine killifish, we illustrate how genomics tools may be useful for screening chemicals and pollutants for biological activity and to reveal specific mechanisms of action. Hypertensive emergency due to pheochromocytoma crisis complicated with refractory hemodynamic collapse. Arteriectasis, subarachnoid hemorrhage in a three-month-old infant. The value of transesophageal echocardiography in the investigation and management of cryptogenic cerebral ischemia: a single-center experience. Furthermore, by assessing the capability of lymphatic endothelial cell forming lymphatic vessel-like structures in vitro, it appears to enhance lymphangiogenesis. Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth.

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Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function. In this study, no relationship between radiation dose to the NVB and the development of post brachytherapy erectile dysfunction was discernible. Progression-free survival, overall survival (OS), and toxicity were secondary end points. Endothelium was stained with antiCD31 antibody, and measurements were made using a computerised image analysis in the whole study population and separately for two subgroups with and without metastases to axillary lymph nodes. The endothelin-A- and -B- (ETA/ETB) receptor cordarone 200 mg medication antagonist (TAK-044, Takeda Chemical Industries, Osaka, Japan) was administered subcutaneously at a dose of 10 mg/kg/day from the age of 8 weeks for 4 weeks.

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Furthermore, biphasic ARRHENIUS plots indicate a multiple character of the HPS from these species as could already be demonstrated with the enzyme from Bacterium MB 58 and Pseudomonas oleovorans. Two outpatient dermatologic clinical practices (a county hospital and a private practice). Laryngoscopy with a straight blade was performed on 7 fresh human cadavers. There were no adverse effects of HVHF reported.There is insufficient evidence to recommend the use of HVHF in critically ill patients with severe sepsis and or septic shock except as interventions being investigated in the setting of a randomized clinical trial. Adherence to the principles and techniques elucidated in this article will facilitate the care of these difficult problems. The resulting GEO basis set opens the way for a fully controlled optimization of many-body wave functions in electronic structure calculation of bulk materials, namely, containing a large number of electrons and atoms. Furthermore, the comparison between numerical results from anisotropic and isotropic models shows the optimal configuration of foot skin. The findings suggested that suppressing COX-2 can improve steatohepatitis by inhibiting hepatocyte apoptosis in mice via regulating the Akt/p53 pathway.

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Despite emerging evidence illustrating the benefits of physical activity for people with binge eating disorder, engaging this population in physical activity is challenging. To investigate the relationship between plasma levels of BDNF and anthropometric factors, metabolic derangements due to obesity, adipocytokine levels and birth weight in obese Japanese children. In Japanese patients with newly diagnosed type 2 diabetes who were relatively lean but had excess VAT, diet with or without voglibose or glyburide effectively reduced VAT. Significant predictors of higher perceived risk/stigma scores included region of origin, age, place of diagnosis, English fluency, time in the US/Canada, TB symptoms, and household rooms. Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of autosomal disorders. Serum levels of 25-hydroxyvitamin D (25-VD) at entry were measured for cases and controls. Both processes are transient and active already before the saccade onset. After a 2-4 week run-in period, participants were assigned to a diet based on wholegrain (wholegrain group) or on refined cereal products (control group), each one for a duration of 12 weeks. Quick nuclear transportation of siRNA and in vivo hepatic ApoB gene silencing with galactose-bearing polymeric carrier. Information about the 3D structure and binding mode of Anoga-HrTH to its receptor is vital for the design of suitable mimetics which can act as insecticides.

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Bioprospecting from marine sediments of New Brunswick, Canada: exploring the relationship between total bacterial diversity and actinobacteria diversity. Findings of the investigation revealed that Ibuprofen through developed MMEI was shown to protect neurons against MPTP-induced injury in the Substantia nigra pars compacta (SNpc) and striatum and hence, could be a promising approach for brain targeting of Ibuprofen through intranasal route to treat PD. These methods may overemphasize cognitive skills while underemphasizing technical skills and completely ignoring team and human factor skills. Imaging methods, both morphological and functional, are of great importance in presurgical evaluation. On the corrective surgery of obstructions of the seminal vesicles, with special reference to the therapeutic value of epididymo-deferentostomy (clinical study). Staff in GH homes with lower hospital transfer rates employed care processes that maximized these opportunities. Moreover, injection of small-molecule inhibitors of cathepsin into the WT silkworms prevented PSG destruction and delayed pupation, confirming the role of BCPI in inhibiting cathepsin activity.

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In doing this we examine how in each country nursing has developed different ideologies and strategies. Counterfactual processing of economic action-outcome alternatives in obsessive-compulsive disorder: further evidence of impaired goal-directed behavior. The cases were followed up from 6 to 12 months with an average of 11 months. The performance of SABRE is compared to that of the finite difference (FD) method in numerical experiments using data from a simulated Shack-Hartmann lenslet array. Non-centrosomal microtubules regulate F-actin organization through the suppression of GEF-H1 activity. FSGS without GVHD after HSCT, such as that observed in our case, is rare. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein. The aim of this study was to compare surgical to conservative treatment of outcomes for primary patellar dislocation by meta-analysis all the relative randomized controlled trials.

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Halothane and desflurane requirements in alcohol-tolerant and -nontolerant rats. In this paper, a nonviral gene delivery system GE7, which was designed to target EGF receptor (EGF R) overexpressed on the surface of cancer cel Is through an EGF R-binding oligopeptide (GE7), was used for in vivo gene therapy in a murine subcutaneous hepatoma model. The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here, for the first time, we describe a case of human infection caused by Schwanniomyces etchellsii in a patient with cholecystitis. In spermatocytes, there is an intricate link among DNA repair, glucophage generic equivalent the ubiquitin system, and regulation of meiotic chromatin structure, as indicated by the co-localization of proteins involved in these processes on meiotic recombination complexes. Spatial displacement of diffusion-weighted images was calculated using a 3D turbo spin-echo acquisition as a reference. Iron complexes of N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)-methylamine (N4Py) have proven to be excellent synthetic mimics of the Bleomycins (BLMs), which are a family of natural antibiotics used clinically in the treatment of certain cancers.

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