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Elavil (Amitriptyline)

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Elavil is a type of drug called a tricyclic antidepressant. These drugs were originally developed to treat anxiety and depression, but when taken at a low dose they can reduce or stop pain. Elavil works by increasing the amount of serotonin your brain makes.

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Also known as: Amitriptyline


{name} (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

{name} is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Elavil dosage information


If you overdose Elavil and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Elavil overdosage: seizures, loss of consciousness for a period of time, seeing things or hearing voices that do not exist, agitation, feeling drowsy, rigid muscles, vomiting, high temperature, cold body temperature, problems concentrating, abnormal heartbeats, confusion.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Elavil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Elavil if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Elavil if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Elavil is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Elavil is not approved for use by anyone younger than 12 years old.

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The purpose of the study was to determine if the local or distal injection of neural stem cells can cause functional difference in recovery after chronic spinal cord injury. Mitochondrial autonomy: Synthesis of DNA from RNA templates in isolated mammalian mitochondria. The subjects consisted of 11 men and 8 women, ranging in age from 52 to 96 yr. The most cost-effective options are not specific to blood transfusion recipients and might be more suited to all hospitalized patients. These results imply that specific activation domains stimulate transcription by binding to distinct Mediator subunits. Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation. Throughout the system design and development process, our decisions have been driven by usability concerns. The addition of aprotinin to the Euro-Collins pulmonary flush significantly improves arterial oxygenation in the early reperfusion period. Cyclic Adenosine Monophosphate Activates Retinal Apolipoprotein A1 Expression and Inhibits Myopic Eye Growth. Our findings indicate that it may be feasible to use residential dust for retrospective assessment of PAH exposures in studies of health effects.

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Antibodies to GAD and IA-2 were measured in all samples with ICA of 10 JDF units or more. Psychometric properties of three single-item pain scales in patients with rheumatoid arthritis seen during routine clinical care: a comparative perspective on construct validity, reproducibility and internal responsiveness. Participants were randomly assigned to placebo or alendronate sodium (5 mg/day for 2 years and 10 mg/day for the remainder of the study). Dissipative high phase-lag order numerov-type does zyrtec allergy medicine make you drowsy methods for the numerical solution of the Schrodinger equation. However, the complexity of the information to be analyzed has turned this into a challenging task. Utility of 17 chloroplast genes for inferring the phylogeny of the basal angiosperms. Internal consistency was examined by item analysis and equivalence by interrater reliability. Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats.

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Myeloid-derived suppressor cells, a group of immature neutrophils recently identified as mediators of vasculogenesis and metastasis, were recruited to the tumor in response to ELF5. A new theory of belief bias is proposed that assumes that most reasoners construct only one mental model representing the premises as well as the conclusion or, in the case of an unbelievable conclusion, its logical negation. A simplified model of potassium transport will be used as an example and will be derived in a step by step manner. Recent advancements in high-throughput large-scale analytical methods to sequence genomes of organisms, and to quantify gene expression, proteins, lipids and metabolites have changed the paradigm of metabolic modeling. Operative time, conversion to open procedure, length of stay, complications, and recurrence of disease. This study aims to assess the relationship of serum Mg and vitamin D levels in a nationally-representative sample of Iranian adolescents. These results provide morphologic evidence that amylin may play a role in some discrete sensory functions. Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption. ML-IAP, a novel human IAP, inhibits apoptosis induced by death receptors and chemotherapeutic agents. Inhibitory effects of atropine and hexamethonium on the angiotensin II-induced contractions of rat anococcygeus smooth muscles.

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cDNAs encoding three neuropeptide Y (NPY)-related peptides were identified from the Japanese flounder. Prevalence and correlates of generalized anxiety disorders in primary care. Hemorrhagic infarction and necrosis of the pulmonary tissue after segmental cozaar losartan potassium tablets 50 mg resection. Plasminogen mRNA expression was detected in cerebral, hippocampal and cerebellar neurons. Based on the phenomenon of plasmid incompatibility, we developed molecular tools for target-oriented plasmid curing and could generate customized mutants lacking hundreds of genes. Middle ear effusions from infected animals contained antibodies to type 3 pneumococcal polysaccharide, whereas the sera of these animals lacked this antibody, suggesting that resistance to reinfectin was due to local immune mechanisms. To update the analysis of the regulatory review interval for ophthalmic new drug applications at the United States Food and Drug Administration for the years 1997 to 1999, based on the previous review by the author of the period 1990 to 1996.

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Data were extracted on the clinical features, examinations, treatments and clinical outcome. Ontogeny of a surgical technique: Robotic kidney transplantation with regional hypothermia. Changes in Axial Length and Refractive Error After Noninvasive Normalization of Intraocular Pressure From Elevated Levels. Patients were classified as responders or nonresponders on the basis of the changes of tumor size revealed on CT after three transcatheter arterial chemoembolization treatments. FSD needs to be recognized as a significant public health problem in Kurd women. Disaster planning for psychiatric casualties for general hospitals with psychiatric services. Oncogenic properties of desoxyribose nucleic acid isolated from parotid gland carcinomas. A solvent effect on the mutagenicity of tryptophan-pyrolysate mutagens in the Salmonella/mammalian microsome assay. Mineral content of blood plasma and liver in swine and sheep infected with larvae from Taenia hydatigena.

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Electron microscopic and genetic studies of a temperature-sensitive recombination mutant. Prophylactic intravenous bolus ephedrine for elective Caesarean section under spinal anaesthesia. It has been shown that how well the experimentally obtained output current profile matches with the numerically computed output. Therefore, chromatin assembly is a process that affects DNA replication, repair, and gene expression. The stages of 416 breast cancer patients, treated at our hospital in 1996, were classified according to the TNM classification, sixth and seventh editions, and their prognoses were compared. Local recurrence and right hydronephrosis disappeared on positron emission tomography performed 4 years postoperatively. The two loci map in the box region, the split gene coding for apocytochrome b. However, the precise mechanisms by which in situ amorphisation occurs are often not fully understood.

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Embryo selection in IVF/ICSI cycles using time-lapse microscopy and the clinical outcomes. All the peptides showed similar abilities to bind to bacterial lipopolysaccharide (LPS) and permeabilize bacterial outer membranes. Addition of 20-hydroxyecdysone supported long term acquisition of competence for DNA synthesis in the wing discs. However, inhibition of the p38 pathway prevented the insulin-stimulated decrease in GLUT4 protein levels. Using our surgical database, we retrospectively identified 363 patients who were candidates for in situ ulnar nerve decompression for the treatment of cubital tunnel syndrome over a 5-year period. A retrospective chart review was performed to determine patient outcomes before and after partnership by gynecologic oncologists (GYN/ONC) with a sarcoma center (SC) for patients with recurrent unresectable/metastatic (RM) uterine leiomyosarcoma (uLMS). Cone diameters in different retinal areas correlate with the differing physical constraints in the respective visual field. We used an anchor-based approach to estimate MCIIs for three measures of RA activity (patient global can i take sinus medicine with zyrtec assessment, swollen joint count, and walking time).

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Measuring Disability: Comparing the Impact of Two Data Collection Approaches on Disability Rates. Surgical treatment of APVS has got favourable outcomes in terms of mortality and reoperation rate. The effect of dynamic annular motion clearly demonstrated reduced regions with large stress values and provided an improved accuracy in determining the location of improper leaflet coaptation. This has led to the idea that suppression of blood vessel growth (anti-angiogenic therapy) may be a successful therapeutic why does amiodarone need loading dose approach for endometriosis. Further investigation of this radionuclide for RIT of melanoma is warranted.

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Downregulation of Nrf2 by the combination of TRAIL and Valproic acid induces apoptotic cell death of TRAIL-resistant papillary thyroid cancer cells via suppression of Bcl-xL. These data suggest that, far from being a quiescent state during which the cortex and subcortical structures are globally inhibited, slow-wave sleep may consolidate memory traces acquired during wakefulness in corticothalamic networks. Using recently developed diagnostic and treatment methods, we successfully diagnosed and treated a case of subclavian steal syndrome. In vitro kinase assays revealed that CKII-catalyzed phosphorylation increased the affinity of Jun for the DNA. These results confirm selective and marked degenerations of basal ganglia cholinergic and dopaminergic terminals in PSP. Because intensive care physicians are caring for an increasingly heterogeneous population of patients, the indications for aggressive monitoring and close titration of care have expanded.

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Structural analysis confirms binding of LJH685 to the RSK2 N-terminal kinase ATP-binding site and reveals that the inhibitor adopts an unusual nonplanar conformation that explains its excellent selectivity for RSK family kinases. Furthermore, LY311727, a reported specific hGIIA sPLA(2) inhibitor, is able to inhibit the synthetic and the recombinant enzymes with the same efficiency. Quantitative analysis of chlorpheniramine maleate and phenylephrine hydrochloride in nasal drops by differential-derivative spectrophotometric, zero-crossing first derivative UV spectrophotometric and absorbance ratio methods. To further explore the expression patterns of the identified growth factors in roe deer their expression levels were standardised using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene expression. Follow-up studies will be necessary to establish whether the locus near TSPAN2 can be a target for a novel therapeutic approach to stroke prevention.

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