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Daocon (Glibenclamide)

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Daocon is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
Afdiex, Aviglen, Benclamet, Benformin, Betrol, Bionil, Combidos, Daocon, Daonil, Diabetnil, Diabnil, Duotrol, Dutrol, Euglucon, Eumet, Giclamide, Glibact, Glibson, Glime, Glimsug, Glinil, Glitrac, Gluconil, Glucosafe, Glutowin, Glybid, Glybovin, Glybovine, Iscept, Metclam, Metica, Monomet, Pionorm, Secrin, Sugatrol, Sycored, Symet, Triglucored, Triglycomet

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Aristocort, Abhigra, Amethopterin, Loxitane, Imodium, Abilify, Actos

Also known as: Glibenclamide


{name} is an oral diabetes medicine that helps control blood sugar levels.

{name} is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

{name} is not for treating type 1 diabetes.


Usual Adult Dose for Diabetes Type 2:

Doses provided as Daocon-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Daocon (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Daocon and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Daocon (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Daocon-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Daocon component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Daocon/metformin dosage information


In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Daocon are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Daocon and metformin if you are allergic to Daocon or metformin, or:

severe kidney disease; metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment); or if you are also using bosentan (to treat pulmonary arterial hypertension).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Daocon and metformin.

Tell your doctor if you have ever had:

kidney disease; an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); liver disease; or heart disease, heart attack, or stroke.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Daocon and metformin for a short time just before your due date.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while taking Daocon and metformin.

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Mutational and evolutionary analysis of an archaebacterial gene. Triple approach strategy for patients with locally advanced pancreatic carcinoma. The change of nutrition status of the civilian Chinese population of Taiwan in the recent 16 years. We used the human esophageal squamous cell lines TE2 and T.Tn treated with celecoxib and 5-FU/radiation, after which cell viability assays were performed. A case of protein-losing enteropathy associated with autoimmune mechanism. Hoxb6 can interfere with somitogenesis in the posterior embryo through a mechanism independent of its rib-promoting activity.

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The SEM is a complementary and modern method of lung observation. CD95 (APO-1/FAS) deficiency in infant acute lymphoblastic leukemia: detection of novel soluble Fas splice variants. Erosion resistance and behaviour of highly organic in-sewer sediment. Cell type- and input-specific differences in the number and subtypes of synaptic GABA(A) receptors in the hippocampus. Isotope clearance studies in peripheral vascular reconstruction.

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The prevalence of hypertension is diverse in Chinese populations with different geographic region, lifestyles and cultures. Alteration of drug biotransformation and elimination during infection and inflammation. The in vivo position of the juxtaglomerular cells remaining in the present preparation, situated at the polkissen only few microns from the only hypoosmotic area in the body, suggests that the extreme osmosensitivity of renin release from isolated glomeruli represents a physiologic phenomenon. Further evidence for a specific ganglioside fraction closely associated with myelin. We suggest that such high-level cognitive functions are dissociable by frequency-specific neuromodulatory effects, possibly related to entrainment of specific brain rhythms.

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The Effect of Electroconvulsive Therapy on Tardive Dyskinesia: A Prospective Study. Obsessive-compulsive disorder and comorbid anxiety problems in a national anxiety chloromycetin drug class screening sample. In this paper we focus on the hospital discharge scenario and first describe a novel interface called Twinlist. Results of the current study confirm that apoptosis occurs in a specific temporo-spatial sequence in the hindgut and cloaca and appears to be an important mechanism in TG regression, uro-rectal separation, urethral opening, and rupture of the anal membrane. Elevated Plasma Connective Tissue Growth Factor Levels in Children with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease.

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sigirr-/- alveolar macrophages and neutrophils exhibited an increased capacity to phagocytose viable pneumococci. At present, biopsy of the internal mammary nodes in the first and second intercostal spaces is indicated for assessing nodal status and planning treatment. Clinical significance of faecal calprotectin levels in patients with ulcerative colitis. Chronic electrical stimulation of the deaf ear is an ideal preparation for further studies in which to extrapolate findings from in vitro depolarization models. A cross-linguistic levaquin kidney infection fMRI study of perception of intonation and emotion in Chinese. This study evaluates the self-perceived dentinal sensitivity and erosive effects of wine on the professional wine tasters of the Granite Belt and the Scenic Rim regions of South East Queensland, Australia. Retrospective analysis of a prospectively collected database (Canadian Task Force classification II-2). Nurses worry that health care industry will use staffing crisis to replace RNs. The aim of this study was to identify the relationship between low temperatures in winter and mortality due to cancer, cardiovascular diseases and respiratory diseases. At a functional level, glutamate transport and catabolism are impaired in astrocytes.

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Identification of effective screening strategies for cardiovascular disease prevention in a developing country: using cardiovascular risk-estimation and risk-reduction tools for policy recommendations. Our data demonstrate significant and specific topographic EEG changes during tonic muscle pain. Anonymous, self-administered GHPSS questionnaire covering demographics, tobacco use prevalence, secondhand smoke (SHS) exposure, desire to quit smoking and training received to provide cessation counseling to patients was used. The hyphal growth and the amount of zoospores produced from these isolates differed and there was no evident relationship between them, which indicated the existence of genetic diversity among the isolates in China. The noroxin tabletas 400 mg science of food allergy has been rapidly evolving before our eyes in the past half century. Factors that influence test selection are discussed, and specific recommendations are made on the basis of best evidence. Recent advances in structural biology and single-molecule studies have given great insight into the structure and function of NER components. However, it has become extremely difficult to find qualified instructors who can fit into an academic environment that stresses research funding and publications for promotion.

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