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Daocon (Glibenclamide)
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Daocon

Daocon is an anti-diabetic medication (biguanide). It works by lowering glucose production in the liver, delaying the absorption of sugar (glucose) from the intestines, and increasing the body's sensitivity to insulin.

Other names for this medication:
Afdiex, Aviglen, Benclamet, Benformin, Betrol, Bionil, Combidos, Daocon, Daonil, Diabetnil, Diabnil, Duotrol, Dutrol, Euglucon, Eumet, Giclamide, Glibact, Glibson, Glime, Glimsug, Glinil, Glitrac, Gluconil, Glucosafe, Glutowin, Glybid, Glybovin, Glybovine, Iscept, Metclam, Metica, Monomet, Pionorm, Secrin, Sugatrol, Sycored, Symet, Triglucored, Triglycomet

Similar Products:
Aristocort, Abhigra, Amethopterin, Loxitane, Imodium, Abilify, Actos

Also known as: Glibenclamide

Description

{name} is an oral diabetes medicine that helps control blood sugar levels.

{name} is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

{name} is not for treating type 1 diabetes.

Dosage

Usual Adult Dose for Diabetes Type 2:

Doses provided as Daocon-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Daocon (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Daocon and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Daocon (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Daocon-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Daocon component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Daocon/metformin dosage information

Overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Daocon are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Daocon and metformin if you are allergic to Daocon or metformin, or:

severe kidney disease; metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment); or if you are also using bosentan (to treat pulmonary arterial hypertension).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Daocon and metformin.

Tell your doctor if you have ever had:

kidney disease; an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); liver disease; or heart disease, heart attack, or stroke.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Daocon and metformin for a short time just before your due date.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while taking Daocon and metformin.

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Our main aim was to assess the level of persistence and adherence to therapy with glucagon-like peptide-1 (GLP-1) receptor agonists in type 2 diabetes mellitus (T2DM) patients in the United Kingdom (UK) and Germany, also by comparing once- (OD) with twice-a-day (BID) therapy. Furthermore, we have found that we can improve TRAIL sensitivity in NB by reconstituting caspase 8 with IFN-gamma and TR2 with chemotherapeutic agents. There was no significant between-group difference in mean heart rate or systolic and diastolic blood pressure at any of the time points. Experimental study of the penetration into the ocular fluids of neomycin used in sub-conjunctival injections. Influence of different antigens on circulating lymphocyte populations. Antarctic krill (Euphausia superba) acquire a UV-absorbing mycosporine-like amino acid from dietary algae. We have studied whether immature FGFR3 isoforms mediate the abnormal signaling in TDII. Isolation-rearing of rats causes a variety of behavioral changes, including anxiety, learning deficits and sensory changes related to schizophrenia. In animal models, lowering dietary ARA or linoleic acid generally lowers levels of brain ARA and raises DHA. The molecular modeling of Co(II)-bleomycin previously performed by us through NMR and molecular dynamics indicates that the most favorable structure for this complex is six-coordinate, with the secondary amine in beta-aminoalanine, the N5 and N1 nitrogens in the pyrimidine and imidazole rings, respectively, and the amide nitrogen in beta-hydroxyhistidine as equatorial ligands.

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To examine the association between mass media attention regarding invasive group A streptococcal (GAS) disease and testing for GAS in a pediatric emergency department (ED). We believe that the mechanism generalizes to more complicated theories. Assessment of up to twelve protecting groups in a single experiment has been demonstrated. Adenosine and CPA were introduced 60 min before injury by subcutaneous injections in a dose of 300 and 2.5 micrograms/kg, respectively. Tobacco on the web: surveillance and characterisation of online tobacco and e-cigarette advertising. Biotransformation of colchicinoids into their corresponding 3-O-glucosyl derivatives by selected strains of Bacillus megaterium. sexta BBMVs, (c)RR-AA and (c)RR-EE showed great reductions in BBMV binding. 305400) is an X-linked condition characterized by short stature, macrocephaly, facial, genital and skeletal anomalies.

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Truncated active matrix metalloproteinase-8 gene expression in HepG2 cells is active against native type I collagen. The biomechanical effects of fatigue on the porcine bioprosthetic heart valve. Use of Observation Stays in Calculating Hospitalizations Among Medicare Beneficiaries. Antimicrobial activity of essential oils from Mediterranean aromatic plants against several foodborne and spoilage bacteria. Membrane protein modification can change cell surface properties which can be correlated with altered macrophage-erythrocyte interactions. We sought to identify risk factors that are associated with prolonged mechanical ventilation in this population. Functional asymmetry of emotions in primates: new findings in chimpanzees. In this study, 55 patients with idiopathic scoliosis of varying types and severity were followed longitudinally with serial radiographs and platelet calmodulin determinations. A cross-sectional survey of 196 family caregivers (CGs) of people with dementia (CGs) was conducted to determine the factor structure of a SEQCFC of people with dementia.

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