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Celira

Celira is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis.

Other names for this medication:
Celact, Celcib, Celcox, Celebix, Celecap, Celecoxib, Celedol, Celemax, Celetop, Celexax, Celfast, Celib, Celira, Cobix, Colcibra, Coxib, Eloxib, Orthocel, Orthocell, Revibra, Sionara, Zecoxib, Zycel

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Also known as: Celecoxib

Description

{name} (celecoxib) is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.

{name} is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain.

{name} is used to treat juvenile rheumatoid arthritis in children who are at least 2 years old. It is also used in the treatment of hereditary polyps in the colon.

Dosage

Usual Adult Dose for Pain:

Acute pain: 400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed.

Usual Adult Dose for Dysmenorrhea:

400 mg initially, followed by 200 mg if needed on the first day. Then, 200 mg twice daily as needed.

Usual Adult Dose for Osteoarthritis:

200 mg orally once daily or 100 mg orally twice daily.

Usual Adult Dose for Rheumatoid Arthritis:

100 to 200 mg orally twice daily.

Usual Adult Dose for Familial Adenomatous Polyposis:

400 mg orally twice daily with food.

Usual Adult Dose for Ankylosing Spondylitis:

200 mg orally once daily or 100 mg orally twice daily. If after 6 weeks of therapy no results are observed, a trial dose of 400 mg orally daily may be worthwhile. If no response is seen after 6 weeks, consideration should be given to alternate treatment options.

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis:

2 years or older: 10 to less than or equal to 25 kg: 50 mg orally twice daily Greater than 25 kg: 100 mg orally twice daily

Detailed Celira dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Celira are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Celira if you are allergic to celecoxib, or if you have:

an allergy to sulfa drugs; or a history of asthma attack or severe allergic reaction after taking aspirin or an NSAID.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

a stomach ulcer, bleeding in your stomach or intestines; heart disease, high blood pressure; asthma; bleeding problems; liver or kidney disease; or if you smoke or drink alcohol.

If you are pregnant, you should not take Celira unless your doctor tells you to. Taking a NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

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Optogenetic stimulation of c1 and retrotrapezoid nucleus neurons causes sleep state-dependent cardiorespiratory stimulation and arousal in rats. Meeting the challenge of the new millennium: caring for culturally diverse patients. (E)-1,3-diphenyl-1H-pyrazole derivatives containing O-benzyl oxime moiety as potential immunosuppressive agents: Design, synthesis, molecular docking and biological evaluation. Advancing this further, the study proposes a captivating solvent free method for the preparation of green PLGA-oil nanohybrids (G-PONHs) using acrysol oil and encapsulation of resveratrol therein. Although sulfonylureas have been used for more than 40 years, it is only recently that their molecular mechanisms of action have been elucidated. Advancement genioplasty is a valuable tool that can address both functional and aesthetic issues. Staining of syncytiotrophoblast brush border and cytotrophoblast, granular in appearance was observed in first trimester human placenta. While their mRNA structure has been reported, the full genomic organization of these genes, is not known. Northern and in situ hybridization studies showed that hypothyroidism induces a marked increase in L1 mRNA levels in the caudate putamen, cerebral cortex, amygdala, and some thalamic nuclei. PubMed was searched for recent articles (2008-2012) on the topic of risk factors for GBC.

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Persistence at air reduction may be successful and the success rate increases with delayed attempts but the risks of the increasing radiation burden must be weighed against the risks of emergency surgery and anaesthesia.Heenan, S. A significant increase in the number of mouse peritoneal exudate cells (PEC) was noted following inoculation with the mycelium. These results imply that exogenous or endogenous carbon sources may affect the oral and vaginal carriage of C. Inhibition of this circulating TF prevented formation of thrombi on collagen-coated glass slides in an ex vivo perfusion system. Using the NoTS, we test the interactions among components in photobodies. Its pathophysiology is uncertain, and the implication of EBV is discussed. Computing semantic similarity between biomedical concepts using new information content approach. The chemical theory suggests that bronchoconstriction is due to local excess of mediators from cells taking part in the allergic and inflammatory reactions, and which are found in the tracheobronchial tree. The authors received financial support from the IMK Almene Fond. Furthermore, the chromodomain- and SUMO E3 ligase-dependent Cbx4 activities differentially regulate proliferation, differentiation, and expression of nonepidermal genes in KCs.

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The formation of low-volatility products from reactions of phthalic acid with ammonia is proposed as one possible mechanism to explain the high f(part) of phthalic acid. In two patients studied six and 12 months after transplantation, macrophage functions returned toward normal except for a persistent defect in killing of C. Injection of B6 splenocytes into CB6F(1) initiated an initial burst of parental cell engraftment similar to that of B6 into B6D2F(1). Glomerulopressin also restored GFR and urinary flow in animals that had remained anuric for 24 hours. Just over 150 reports of this phenomenon exist in English medical literature. Catecholamines in the blood and the renin-angiotensin-aldosterone axis in essential hypertension. The purpose of this study was to describe the procedure and outcome of creating a neovaginal pouch lined with autologous buccal mucosa.

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High-level Policy Makers Forum on achieving self-sufficiency in safe blood and blood products, based on voluntary non-remunerated donation (Rome, 8-9 October 2013). The objective here was to elucidate the molecular mechanism by which statins induce lymphoma cells death. The results suggest a two-stage process in which charge neutralization first triggers condensation, resulting in the emergence of previously cryptic structures that subsequently mediate reversible, hierarchical assembly. For example, William Harvey in the 16th and 17th centuries clarified the importance of the circulatory system, aided by observations in dogs and pigs, which helped to clarify and confirm his concepts. One promising therapeutic development is to design new molecules that balance actions on dopamine D2 and D3 receptors to maximise benefits and limit adverse effects. Besides, it was found that the drug can inhibit the activity of cytokines (IL-l gamma, and TNF gamma), which can be of significant practical importance in the treatment of myocardial ischemia and chronic heart insufficiency.

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Variance analysis and linear regression analysis were used in this study. We suggest that the leptin pathway plays a role in the regulation of longevity, possibly by modulating the risk of development of MI and of DM2. Liver-derived HRG, similar to alarmins, appears to be an endogenous molecular factor promoting polarization of hepatic macrophages toward the M1 phenotype, thereby promoting chronic liver injury and fibrosis progression, but limiting angiogenesis. It is now clear that centrosome movement occurs not only prior to cell division but also at its completion, in concert with cytokinesis. Studies with large sample size are needed to uniformly validate symptom improvement in EoE. Afferent and efferent vessels of HCC lesions come to differ as the lesion develops. The findings have implications for timing of screening programs. Identification of the permeability field of a porous medium from the injection of a passive tracer.

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This method was adopted as a suitable therapy for treatment of a patient who suffered from a complex wound at high-risk of reinfection. The hazard from microbiological contamination in the interiors of components of planetary-impacting spacecraft has been generally recognized, but techniques for experimentally evaluating the significance of this hazard have been unavailable. Our results are important to provide large quantities of human P450arom as an active form for structure-function studies. Different activators interact with Mediator via distinct binding targets. Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells. To investigate the relationship among horizontal corneal diameter, corneal thickness, anterior chamber depth, pupil size, and spherical equivalent and to evaluate the variation in these parameters attributable to age, sex, iris color, and refractive state of the eye. Two hundred and forty-nine patients recorded on NHS records as listed for joint replacement completed a range of measures prior to surgery.

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Adenomyosis and subfertility: evidence of association and causation. Here, we proposed that oestrogen is also imparted in a post-lupus symptomatic enhancement as studied in the C4-deficient (C4-/-) mice model known to develop SLE-like symptoms. Our results therefore show that reduction of either the density of mobile ionic species or carrier trapping at the perovskite interface will remove the adverse hysteresis in perovskite solar cells. Studies were identified zebeta generic by searching MEDLINE, reviewing references from retrieved articles, and scanning abstracts from conference proceedings. Detection of mammalian reovirus RNA by using reverse transcription-PCR: sequence diversity within the lambda3-encoding L1 gene. The influence of silver additives on titania photoactivity in the photooxidation of phenol.

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Plasma amylin and insulin were measured in 283 medication-free individuals stratified by blood pressure status (82 hypertensive and 201 normotensive), and genetic risk (family history) of hypertension. Tissue damage as a result of electrical injury occurs by two mechanisms which are summative in action and have a variable degree of contribute to the ultimate damage produced. The left amygdala and ventromedial prefrontal cortex were activated during positive emotion, and bilateral amygdala activation occurred during negative emotion. TIMP-1 conferred highly significant protection to hippocampal cells exposed to a wide range of glutamic acid concentrations in both dissociated and organotypic hippocampal cultures. Chiral recognition between a substituted cyclooctatetraene dianion and a half crown ether substituted with ibuprofen. The main target step(s) of CSD3 in the replication cycle is after cell-binding but before or at primary transcription. OCT creates cross-sectional images that have potential diagnostic value for dental applications. Liver citrate levels in parathyroidectomized rats fed toxic amounts of inorganic fluoride. Furthermore, Y-27632 enhances sprouting of CST fibers in vivo and accelerates locomotor recovery after CST lesions in adult rats.

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However, while the flowers within the Brassicaceae members are rather uniform, mainly radially symmetrical, mostly white with fixed organ numbers, species within the Cleomaceae, the sister family to the Brassicaceae show a more variable floral morphology. This imaging technique may have broad application for a variety of endoscopic operative procedures with the potential to impact on operative decision-making and requires further evaluation. However, clinical trials may not accurately reflect what happens in clinical practice. Under appropriate conditions, mixtures of cationic and neutral lipids and DNA in water condense into complexes in which DNA strands form local two-dimensional (2D) smectic lattices intercalated between lipid bilayer membranes in a lamellar stack. Crystallization and preliminary X-ray diffraction studies of two different crystal forms of the lipase 2 isoform from the yeast Candida rugosa. These findings implicate Peg3/Pw1 as a mediator between p53 and Bax in a neuronal cell death pathway activated by DNA damage. We aimed to determine the association between elevated BP levels and the occurrence of new CMBs after a 2-year follow-up in first-ever lacunar stroke patients using ambulatory BP monitoring. The early detection of alcohol consumption (EDAC) score in the identification of Heavy and at-risk drinkers from routine blood tests. Capsulotomy for refractory anxiety disorders: long-term follow-up of 26 patients.

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