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Cefpodoxim (Cefpodoxime)

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Cefpodoxim (generic name: cefpodoxime proxetil; brand names include: Cefocep) is used for treating mild to moderate infections caused by certain bacteria. Cefpodoxim is an oral third generation cephalosporin antibiotic. It is used to treat infections such as pneumonia; bronchitis; gonorrhea; and ear, skin, throat, and urinary tract infections. Cefpodoxim works by interfering with the formation of the bacteria's cell wall so that the wall ruptures, resulting in the death of the bacteria. It treats many kinds of infections, including those of the respiratory tract, skin, and ears.

Other names for this medication:
Belpro, Cefdolife, Cefdox, Cefirax, Cefobid, Cefodox, Cefolex, Cefomin, Cefoprox, Cefpodoxime, Cefpodoximum, Cefpolek, Cepdoxim, Cepodem, Desbac, Dofixim, Kindcef, Orelox, Otreon, Pedicef, Podomexef, Rovantin, Sefox, Starpod, Tambac, Taxetil, Trucef, Weijiexin, Ximeprox, Ximocef

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Also known as: Cefpodoxime


Cefpodoxim is an oral, third-generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Currently, it is only marketed as generic preparations in the USA, according to the FDA Orange Book. It is commonly used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.

Cefpodoxim inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls. It has well established pharmacokinetic profile with absorption of 50%. It is indicated in community acquired pneumonia, uncomplicated skin and skin structure infections, and uncomplicated urinary tract infections.


Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You or your child must take the tablets with food, while the oral liquid may be taken with or without food.

Shake the oral liquid well before each use. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Keep using this medicine for the full treatment time, even if you or your child feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (suspension or tablets): For bronchitis: Adults and teenagers 12 years of age and older—200 milligrams (mg) every 12 hours. Children younger than 12 years of age—Use and dose must be determined by your doctor. For ear infections: Infants and children 2 months to 12 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 5 milligrams (mg) per kilogram (kg) of body weight every 12 hours. Infants younger than 2 months of age—Use and dose must be determined by your doctor. For gonorrhea: Adults and teenagers 12 years of age and older—200 milligrams (mg) taken as a single dose. Children younger than 12 years of age—Use and dose must be determined by your doctor. For pneumonia: Adults and teenagers 12 years of age and older—200 milligrams (mg) every 12 hours. Children younger than 12 years of age—Use and dose must be determined by your doctor. For sinusitis: Adults and teenagers 12 years of age and older—200 milligrams (mg) every 12 hours. Infants and children 2 months to 12 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 5 milligrams (mg) per kilogram (kg) of body weight every 12 hours. Infants younger than 2 months of age—Use and dose must be determined by your doctor. For skin infections: Adults and teenagers 12 years of age and older—400 milligrams (mg) every 12 hours. Children younger than 12 years of age—Use and dose must be determined by your doctor. For sore throat and tonsillitis: Adults and teenagers 12 years of age and older—100 milligrams (mg) every 12 hours. Infants and children 2 months to 12 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 5 milligrams (mg) per kilogram (kg) of body weight every 12 hours. Infants younger than 2 months of age—Use and dose must be determined by your doctor. For urinary tract infections: Adults and teenagers 12 years of age and older—100 milligrams (mg) every 12 hours. Children younger than 12 years of age—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, stomach pain, and diarrhea.


Store Cefpodoxim at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 to 86 degrees F (15 to 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cefpodoxim out of the reach of children and away from pets.

Side effects

The most common side effects associated with Cefpodoxim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


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To evaluate the impact and appropriateness of programmes for the management and treatment of severe malnutrition in emergency situations. Immunohistochemical analyses revealed that neither normal bone marrow (BM) plasma cells (PCs), premalignant PCs of patients with monoclonal gammopathy of unknown significance (MGUS), nor MM cells with a mature morphology showed expression of YB-1 in situ. Polygalacturonases (PGs) are enzymes essential for the degradation of pectin, an important component of the adhesive material between cells. Medical deontology problems in the practice of the venereologist. The antiangiogenic activity of this heparin derivative was found to be closely associated with antitumoral activity in a mouse model.

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Over the first 6 h of ischemia the relative effectiveness of cytoflavin was higher than that of neuronol. The p53 tumour suppressor gene is the most commonly mutated gene in human and mouse cancers. This over estimate is approximately twice as long as the actual transition time of the trajectory for the expected noise level in neurodegenerative disease datasets. Agents containing a phenolic dihydroxy moiety showed potent (IC(50)10(-6)-10(-7) M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. pylori eradication treatment was equally effective with PPI treatment for the primary or secondary prevention of endoscopic ulcers in NSAID users.

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Variations in size of the bony lumbar canal in patients with prolapse of lumbar intervertebral discs. The bacterial RimL N-acetyltransferase also uses ClAcCoA to chloroacetyl the alpha-amino group of its cognate substrate, the ribosomal L12 protein, and this reaction can be observed in crude extracts. In vertebrate model systems, a single factor-the steroid hormone testosterone-accounts for most, and perhaps all, of the known sex differences in neural structure and behavior. Glucose transporter 5 (Glut5) is a tissue specific transporter that can be found on breast cancer tissues but not on normal breast tissues. The relation between left ventricular diastolic indices and serum ferritin in thalassemia major. In the study presented here, 787 60-year-old men and 226 50-year-old men--all randomly selected from the general population--were examined by questionnaire regarding the presence of joint symptoms, backache, pain in the legs and consumption of analgetics. The role of air pollution in the relationship between a heat stress index and human mortality in Toronto.

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Activation of the high-affinity receptor for IgE, FcepsilonRI, is known to elicit its rapid down-regulation through internalization and degradation. The results of tests on the psychometric properties of the FIN questionnaire demonstrated at least satisfactory validity and reliability, and confirmed that it can be employed to assess the needs of palliative care patients in the Czech Republic. Plant sterols from rapeseed and tall oils: effects on lipids, fat-soluble vitamins and plant sterol concentrations. Thereafter by understanding the protein tertiary structure, allosteric control mechanism appeared. Normal pancreatic islets were positive for LYVE-1, whereas only 2 of 25 PETs were positive, suggesting that most PETs lost LYVE-1 or contained below detectable levels of LYVE-1. Main nodulation signal molecules in the peanut-bradyrhizobia interaction were examined. Furthermore, available data sets are often qualitative, which complicates the definition of truly quantitative models. The high degree of accessibility and ease with which the studies are performed make it a viable alternative to aortography. VTE patients with hidden cancer have an increased incidence of recurrences, major bleeding or death during the first 3 months of therapy. Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells.

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To investigate osteopontin (OPN) levels in both synovial fluid and articular cartilage of patients with primary knee osteoarthritis (OA) and their relationship with severity of the disease. These preclinical studies have supported the development of several clinical trials testing targeted agents for the prevention of breast cancer. Lymph node micrometastasis: a predictor of early tumor relapse after complete resection of histologically node-negative esophageal cancer. Results, in fact, showed that poorly differentiated or undifferentiated forms of prostatic carcinoma contained cells with enhanced positive reactions when compared with strongly differentiated forms. Infrared laser therapy in complex treatment of patients with ischemic heart disease after aortocoronary bypass surgery. Sequence analysis revealed that the channel subunit encoded by HcLGCC1 is anion selective and a member of a group of channels characterized as having two Cys-loops in the N-terminal ligand-binding domain.

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