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Calcitriol

Calcitriol is an active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia. Calcitriol is a biologically active calcitrophic hormone with anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities.

Other names for this medication:
Arachitol, Arcium, Biocitral, Calcibest, Calcikind, Calday, Caldix, Calfa, Caltin, Coecoral, Fovit, Laretol, Minroset, Nutribone, Ostriol, Primacal, Rical, Riecal, Rockbon, Septriol, Solbiocal, Sorvate, Statbone, Vezocal, Zaxial

Similar Products:
Detrol, Aygestin, Cordarone, Mellaril, Aristocort, Zithromax, Ceclor

Description

Generic Calcitriol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Calcitriol are intestine and bone. Generic Calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Calcitriol may also act on the kidney and the parathyroid glands. Generic Calcitriol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Calcitriol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Calcitriol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Calcitriol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Calcitriol produces other independent beneficial effects. Calcitriol is also known as Calcitriol. Generic Calcitriol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Calcitriol is Calcitriol. Brand name of Generic Calcitriol is Calcitriol.

Dosage

This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Calcitriol. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Calcitriol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Calcitriol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

It is especially important that you receive the right amounts of vitamins so that your baby will also get the vitamins needed to grow properly. Infants who are totally breast-fed and have little exposure to the sun may require vitamin D supplementation. However, taking large amounts of a dietary supplement while breast-feeding may be harmful to the mother and/or baby and should be avoided.

Only small amounts of alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol pass into breast milk and these amounts have not been reported to cause problems in nursing babies.

It is not known whether doxercalciferol or paricalcitol passes into breast milk. Be sure you have discussed the risks and benefits of the supplement with your doctor.

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The observed inverse relationship between energy density of foods, defined as available energy per unit weight (kilocalories per gram or megajoules per kilogram), and energy cost (dollars per kilocalorie or dollars per megajoule) means that diets based on refined grains, added sugars, and added fats are more affordable than the recommended diets based on lean meats, fish, fresh vegetables, and fruit. The analysis reveals that the presence of the effector affects the most important components of HbA motions and that heterotropic effectors modify the overall dynamics of noroxin antibiotic the quaternary equilibrium via tertiary changes occurring in regions where conserved functionally significant residues are located, namely in the loop regions between helices C and E, E and F, and F and G, and in concerted helix motions. The presence of the nucleoside analogue lamivudine (3TC), an inhibitor of HBV replication, restored impaired allostimulatory function of HBV-MoDC and up-regulated major histocompatibility complex class II expression. Efficacy and safety of docetaxel for advanced non-small-cell lung cancer: a meta-analysis of Phase III randomized controlled trials. This review summarizes the current understanding of the intestinal microbiota in infants. To evaluate the efficacy of primary interventional urethral realignment (PIUR) in patients with traumatic urethral injuries. The surface morphology of human B lymphocytes as revealed by immunoelectron microscopy. Bioassay-guided isolation of the extract yielded an active compound that was identified as salicylsalicylic acid by physical and spectroscopic methods. In this review, we focus on glioblastomas, describing recent progress and problems in characterizing these cells.

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The generic nexium brands mean level of infectivity in mMBM was assessed to be 1.2 x 10(-5) and 2.36 x 10(-5) ID(50)/ton of mMBM for Study 1 and 2, respectively. Because palmar fibromatosis is known to be associated with cancer, we performed cancer screening and the patient was subsequently diagnosed with fallopian tube cancer. Ten-year evaluation of cementless Buechel-Pappas meniscal bearing total ankle replacement. Results suggest that the new MOME framework performs significantly better than the others tested on the case study presented. Glucagon (250 micrograms IV) induced prominent IRI and C-peptide responses of similar magnitude in hyper- and hypothyroid patients before as well as after treatment. The purified circular hammerhead ribozyme cleaved the template region of human telomerase RNA in a magnesium-dependent manner.

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The aim of this study was to identify determinants of nonadherence to medication in outpatients with established inflammatory bowel disease (IBD). HRQoL at dialysis onset is significantly influenced by the quality of pre-dialysis nephrological care. Univariate analysis showed that males scored higher means than females in driver aggression and thrill seeking and in their general risk acceptance. Independent variables gathered include sociodemographic data, family and personal psychiatric history, and comorbid diagnoses on all DSM-IV axes (including GAF). Both patients showed an abnormality of the retroperitoneal lymphatics, consisting of lymphatic dilatation and cysts. We report our first experience using metyrosine, a tyrosine hydroxylase inhibitor, for preoperative management in a symptomatic patient with a unilateral PHEO. WRKYs, NBS-LRRs, EDS5, ICS1, etc.) were upregulated in T-2 toxin-treated atnfxl1 mutants compared with wild-type plants. Cr-releasing cytotoxicity tests: study of parameters influencing their reliability. Serum concentration of tissue inhibitor increased significantly during the development of Lewis lung adenocarcinoma.

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Efficacy of a skin tear education program: improving the knowledge of nurses practicing in acute care settings. The aim of the study was to assess the degree of LV asynchrony after the first acute myocardial infarction (AMI) in patients with a narrow QRS complex using Doppler tissue imaging and correlate this with the site and extent of the infarction. The SEM micrograph shows that the foam exhibits a perforated porousness stereostructure in shape, and the HRTEM picture of the particles reveals the clear crystal lattice. Our study has identified a unique mechanism that describes how components of pathogens common in the urinary system may contribute to the malignant transformation of benign prostate epithelia. Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1A receptor agonists. Behaviour of chemically modified sodium channels in frog nerve supports a three-state model of inactivation.

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