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Calcirol (Calcitriol)

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Calcirol is a synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Calcirol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. Calcirol receptor-binding protein appears to exist in the mucosa of human intestine.

Other names for this medication:
Alfabond, Alfarich, Apcical, Arachitol, Biocal, Biocitral, Calbory, Calcikind, Calcimet, Calcirol, Calcor, Caldikind, Calotec, Calsure, Calzem, Carcal, Citroj, Coecoral, Devita, Fovit, Lctrol, Novadee, Osteobel, Ostriol, Politrol, Primacal, Rolsical, Septriol, Statbone, Sunmic, Tobalt

Similar Products:
Zyprexa, Zocor, Evista, Amethopterin, Lopid, Hytrin, Vantin, Benicar, Tenormin, Cleocin

Also known as: Calcitriol


Generic Calcirol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Calcirol are intestine and bone. Generic Calcirol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Calcirol may also act on the kidney and the parathyroid glands. Generic Calcirol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Calcirol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Calcirol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Calcirol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Calcirol produces other independent beneficial effects. Calcirol is also known as Calcitriol. Generic Calcirol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Calcirol is Calcitriol. Brand name of Generic Calcirol is Calcirol.


This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Calcirol. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.


If you overdose Generic Calcirol and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Problems in older adults have not been reported with intake of normal daily recommended amounts. Studies have shown that older adults may have lower blood levels of vitamin D than younger adults, especially those who have little exposure to sunlight. Your health care professional may recommend that you take a vitamin supplement that contains vitamin D.

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Fosfomycin trometamol: multiple-dose regimen for the treatment of lower urinary tract infections. Local self-assembly mechanisms underlie the differential transformation of the proximal and distal cut axonal ends into functional and aberrant growth cones. On the problem of psychological (psychometric) diagnosis of intelligence in children with developmental disorders. Health-care institutions and systems may seek to include consumer perspectives on health and health care yet be challenged to involve the most vulnerable sectors, be they persons with disabilities or persons with low socio-economic status living in societies where a top-down approach to policy is the norm. Protein docking using an ensemble of spin labels optimized by intra-molecular paramagnetic relaxation enhancement. Confocal microscopy of the left cornea 8 weeks after the onset of EKC showed many highly reflective dendritic cells at the level of basal epithelium, epithelial basement membrane zone, and anterior stroma, as well as many highly reflective fusiform and round cells within the anterior stroma, with deceasing density in progressively deeper layers of the stroma. The most effective treatment modality or combination of modalities is an area of controversy. Optimizing sedation and analgesia in mechanically ventilated patients--an evidence-based approach.

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Nineteen (13 intervention, 6 control) piglets were subjected to asphyxia until cardiac arrest, by disconnecting the ventilator tube. A closed suction drain tube of 16 or 18 F placed in the subcutaneous tissue with the help of a trocar is used as a bridge. Aberrant DNA methylation is a commonly observed epigenetic change in lung cancer. We aimed to characterise the immunohistochemical expression of M2-PK in archived specimens of pancreaticobiliary and duodenal cancers, premalignant lesions, chronic pancreatitis, and normal pancreas. In this study a total of 1060 patients will be included and analysis of data will be completed in 2010. The authors review the pathophysiologic mechanisms of nephrotoxicity of these drugs and prevention and treatment strategies. In the past two years, significant progress has been made in understanding the mechanism of salicylic-acid biosynthesis and signaling in plants. A kinetic map of protein cavities is computed in terms of on- and off-rates as well as insights into secondary ligand poses. The clinical distribution of an antibody to a metabolite of practolol was investigated, particularly in relation to the oculomucocutaneous syndrome. Metal-to-insulator transition and superconductivity in boron-doped diamond.

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Other minor components, Hb A1a1 and Hb A1a2 are adducts of sugar phosphates at the N-terminus of the beta chain. The aldo-keto reductase (AKR) proteins catalyze reduction of diverse aldehydes and play detoxification roles in many organisms. Relationship between nocturnal penile tumescence parameters, International Index of Erectile Function symptom scores and sildenafil responses1This paper was presented at the 6th Congress of the International Society of Sexual and Impotence Research, Buenos Aires, Argentina, 17-21 October 2004. Here I review how these developments are yielding insights into the mechanism of action of the yellow fever vaccine, one of the most successful vaccines ever developed, and the broader implications for vaccinology. Effectiveness of the sanatorium and climate therapy of chronic pneumonia at different periods of the year.

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In rats the application of 10 mg/kg 6-amino-nicotinamide (6-AN) leads to an accumulation of 6-phosphogluconate, by inhibition of 6-phosphogluconate dehydrogenase in the pentose phosphate pathway, in the cells of the spinal cord. We focused on diabetic subjects and explored the prevalence of RH in primary care practice. An equivalent circuit with an inductive element is presented for modeling the Ge/Si APD. Use of siRNA as a tool is advancing in almost every field of biomedical research, but some of the most dynamic and exciting applications of siRNA are in cancer research. REFOCUS is a 1-year team-level intervention targeting staff behaviour to increase focus on values, preferences, strengths, and goals of patients with psychosis, and staff-patient relationships, through coaching and partnership. Interferon-gamma, tumour necrosis factor-alpha, and interleukin-4 mRNA levels were significantly higher in WT mice than in TNKO mice, while activated hepatic stellate cells (HSCs) and myofibroblasts, a cellular source of TNC and procollagens, were more common in WT livers.

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Starting with the early stages, patients with chronic kidney disease (CKD) experience higher burden of cardiovascular disease (CVD). The high prevalences of HIV and hepatitis B and C viruses require prevention programs based on vaccination against hepatitis B, early diagnosis of these infections and placement of homeless people into health services. Evaluation of liver dysfunction in patients with severe anorexia nervosa (AN) has typically been limited to small case series. The cellular isoform (PrP(C)) is expressed most abundantly in the brain, but has also been detected in other non-neuronal tissues as diverse as lymphoid cells, lung, heart, kidney, gastrointestinal tract, muscle, and mammary glands. Gait has been shown to be a major determining factor of function following limb-salvage surgery. All studies identified had relatively small sample sizes and exhibited large variability.


The Au/Cys electrode with immobilized Mb exhibited electrocatalytic activity toward ascorbic acid (AA) oxidation with an overpotential decrease of over 400 mV and a linear dependence of current on the AA concentration from 0.5 to 5.0 mmol L(-1). Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins. Maternal exposure to water disinfection by-products during gestation and risk of hypospadias. L2C5 MAB binds selectively to August rat L chains, thus showing specificity for Igk-1a determinants. To assess 1) parental opinion regarding appropriateness of triage, 2) utilization outcomes, and 3) the frequency of underreferral with subsequent hospitalization for children triaged by nurses at pediatric call centers. TOF-SIMS and principal component analysis characterization of the multilayer surface grafting of small molecules: antibacterial furanones. Dysregulated iron metabolism has been suspected to be linked to anemia of chronic disease and to cardiovascular disease (CVD). Neurons projecting from area 3a to the motor cortex were most commonly found in cortical layer III, although some were found in layer V. Two patients unable to perform CIC preoperatively were able to perform CIC postoperatively.

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Patients presenting difficulty of urination have a greater chance to demonstrate urinary flow improvement after surgery than patients complaining of urinary frequency. It is shown that the inertial range scaling is similar in all three cases. Leishmania infantum: prime boost vaccination with C-terminal extension of cysteine proteinase type I displays both type 1 and 2 immune signatures in BALB/c mice. Here, we identify two members of the matrix metalloproteinase (MMP) family of enzymes, MMP-1 and MMP-8, which can modulate the tumor matrix and enhance HSV delivery and efficacy. The kinetics of thrombin generation, as evaluated by CAT, correlates with the thrombus generation, as evaluated by thrombelastography and this may in part explain the clinical utility of the TEG in identifying clinically relevant coagulopathies, secondary to impaired thrombin generation. or 0.1, 1 mug/100 g, i.v.) did not show any curative effects on intestinal paralysis in cecectomized rats.

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We reasoned that any useful strategy should classify affected family members within the same type, and that phenotypic variability should be minimized in patients with recessive disease. Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum. Residential Exposure to Pesticide During Childhood and Childhood Cancers: A Meta-Analysis. Ursolic acid (UA) is a pentacyclic triterpenoid with various pharmacological activities, but the molecular targets and underlying mechanisms for its antifibrotic effect in the liver remain elusive. Inhibition of surface immunoglobulin centeral capping of Daudi cells and cell spreading of HeLa-S3 cells by neocarzinostatin. The naturally occurring tumour promoter teleocidin produces a pronounced but transient enhancement of the synthesis of extracellular viral particles in human cells chronically infected with simian retroviruses of type C (baboon endogenous virus, simian sarcoma virus) or type D (Mason-Pfizer monkey virus) or a human cell line-derived type D isolate (PMF virus), respectively.

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The aim of this paper is to review the scientific literature available about the role of FDG-PET in the management of patients with colorectal cancer. An inverse relationship between maturation and proliferation exists. Of these, 5-HT was the only compound which almost invariably antagonized the rhythm. William Henry Howell and Jay McLean: the experimental context for the discovery of heparin. The increase in beta power was correlated with the area under the cocaine plasma versus time curve, but not with the cardiovascular effects of cocaine. Significant differences between the FACs of different genera, species, and, sometimes, strains were revealed. Similarly, agents that block LB69--e.g., antibodies to LB69 as well as YIGSR-NH2 peptide--do not inhibit attachment of nonmotile BAECs to laminin. Recently, the PASBio project proposed a set of propositions and argument structures for biomedical verbs.

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The clinical impact of the procedure is the possibility of early discharge to home rocaltrol dose and early return to work with potential economical benefits. Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. Parry-Romberg syndrome is an extremely rare disease characterized by the slow atrophy of the face involving the skin, subcutaneous tissue, fatty tissue, muscles, and even bones. We, thus, propose that the in vivo embryotoxic effects of various medicines can be estimated fast and accurately using this in vitro cell differentiation system. Pre-placement medical examination and regular follow-up are necessary to prevent the development of toxic hepatitis. Metabolism investigations showed abnormal glucose tolerance tests and low HDL values in some patients, and these could be risk factors for the development of diabetes mellitus and/or cardiovascular complications. Further examination revealed metases of lung cancer in the left adrenal gland, mediastinal and iliac lymph nodes. Securioside B inhibited the growth of the cells stimulated by recombinant M-CSF or GM-CSF, but it scarcely induced cytolysis of the cells under the same conditions. Peripartum cardiomyopathy (PPCM) is a rare cardiomyopathy with a high risk of mortality.

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Rapid CT tests were performed locally on the first vaginal and cervical swabs and the results were read independently by two staff members. Our objective was to assess the diagnostic accuracy of hemoconcentration for cardiogenic pulmonary edema (PE) as the cause of weaning failure, using left ventricular filling pressure elevation assessed by transthoracic echocardiography as the reference standard. This study quantitatively evaluated drug delivery dynamics of CVCs in a laboratory model of continuous drug infusion. L-Proline nutrition and catabolism in Staphylococcus saprophyticus. The basophilic cell lines KU-812 and RBL-703/21 likewise sensitized were compared with peripheral blood basophils by the same approach. Tests investigated were urea, creatinine, urate, total amiodarone cordarone 200 mg protein, albumin, calcium, total bilirubin, alkaline phosphatase (ALP), aspartate transaminase (AST), gamma-glutamyl transferase (GGT) and inorganic phosphate. This focal pattern correlated with the presence of a pathological abnormality on histologic examination in all patients. Although ligands for LuxR have not been identified so far, the nature of different cinnamaldehyde analogs and their effect on the DNA binding ability of LuxR suggest that these compounds act as LuxR-ligands. PGA-collagen scaffolds as bioengineered dermis were randomly divided into A and B groups.

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PHR1, a PH domain-containing protein expressed in primary sensory neurons. Effects of histamine H3 receptors on chemical hyperalgesia in diabetic rats. For that reason, it is important to elucidate how signaling factors work together in a defined number of cells to generate the diverse and precise patterned structures of the mature functional teeth. In zebrafish embryos, each myotome is typically innervated by three primary motoneurons (PMNs): the caudal primary (CaP), middle primary (MiP) and rostral primary (RoP). Minimally invasive coronary artery bypass grafting: dual-center experience in 450 consecutive patients. There might be DV in patients with chronic prostatitis and lower urinary tract symptoms. The theory is then applied to various manifestations of second-order polarization mode dispersions. In vitro, immature Sertoli cells and spermatogonia transduce BMP2 and BMP4 signals by means of SMAD1, SMAD5, and SMAD8. Using a recently developed exposure assessment tool, this study examined the association between shift para que sirve la pastilla provera 5 mg work and obesity among Canadian women from two studies: a cohort of university alumni, and a population-based study. Although all four patients with preoperative cranial neuropathies were found intraoperatively to have fibrosis in the cerebellopontine angle, excellent preservation of facial nerve anatomy and function was possible with salvage microsurgical resection.

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The purpose of this study was to evaluate the readability is biaxin a form of penicillin of written patient education materials used to teach patients about the prevention and care of skin and pressure ulcers. A 68-year-old woman presented with a painless inflammation of the right superior eyelid that had started several weeks before. Toxicological evaluation of live attenuated, cold-adapted H5N1 vaccines in ferrets. 31P-nuclear magnetic resonance analysis of interferon-induced alterations of phospholipid metabolites in interferon-sensitive and interferon-resistant Friend leukemia cell tumors in mice. The results of nap studies appear inconsistent with this hypothesis since late naps produce a disproportionate loss of stage 4 during subsequent sleep.

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All the subjects were divided into groups according to the degree of exposure to BaP. We provide an overview of the ACT paradigm and the existent evidence base for this intervention. The effect of age on outcomes of sling surgery for lexapro 5 mg tablet picture urinary incontinence. Impaired biosynthesis of Allopregnanolone (ALLO), a brain endogenous neurosteroid, has been associated with numerous behavioral dysfunctions, which range from anxiety- and depressive-like behaviors to aggressive behavior and changes in responses to contextual fear conditioning in rodent models of emotional dysfunction. Langmuir and Langmuir-Blodgett films of organophosphorus acid anhydrolase. A 35 year-old civil servant who was involved in a road traffic injury about two years before presentation. The accumulating body of evidence shows that SDB induces changes in the serum levels or secretory patterns of several hormones.

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