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Caduet

Caduet helps improve your cholesterol levels and is a common first-choice medication for people with high cholesterol or heart disease. It is also used for people who are at higher risk of heart disease, such as those with diabetes, even though they may have normal cholesterol levels.

Other names for this medication:
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Also known as: Atorvastatin

Description

{name} (atorvastatin) belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins."

{name} is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

{name} is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors such as genetically high cholesterol.

{name} is for use in adults and children who are at least 10 years old.

Dosage

Take Caduet exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Caduet is usually taken once a day, with or without food. Take the medicine at the same time each day.

Do not break an Caduet tablet before taking it, unless your doctor has told you to.

You may need to stop using this medicine for a short time if you have:

uncontrolled seizures; an electrolyte imbalance (such as high or low potassium levels in your blood); severely low blood pressure; a severe infection or illness; or surgery or a medical emergency.

It may take up to 2 weeks before your cholesterol levels improve, and you may need frequent blood test. Even if you have no symptoms, tests can help your doctor determine if Caduet is effective.

Caduet is only part of a complete treatment program that may also include diet, exercise, and weight control. Follow your doctor's instructions very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Caduet dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 20 to 25 degrees C (68 to 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Caduet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Caduet if you are allergic to atorvastatin, or if you have:

liver disease; or if you are pregnant or breastfeeding.

Atorvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Stop taking Caduet and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking this medicine.

Atorvastatin may pass into breast milk and could harm a nursing baby. Do not breastfeed while you are taking Caduet.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

liver problems; muscle pain or weakness; kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily.

Caduet can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

Atorvastatin is not approved for use by anyone younger than 10 years old.

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In conclusion, increased responsiveness to methacholine following allergen challenge may not be due to an intrinsic change to the smooth muscle per se, but rather to other changes in the lung, which ultimately manifest as an increase in respiratory resistance. Effects of NAC at various concentrations on the growth, adhesion, migration, and invasion of the human bladder cancer cell line were assessed in vitro. PIG-A mutations block glycosylphosphatidylinositol (GPI) anchor biosynthesis, resulting in a deficiency or absence of all GPI-anchored proteins on the cell surface. Impact of PAMAM G2 and G6 dendrimers on bovine serum albumin (fatty acids free and loaded with different fatty acids). The findings here show the differentiation of hMSCs into cells with phenotypic features of endothelial cells using indirect co-culture with mature endothelial cells and provide the evidence that ginsenoside-Rg1 can promote the milieu-dependent endothelial differentiation of hMSCs in vitro. The five components of the KDQOL were the primary end points of this study (burden of kidney disease, symptoms and problems, effects of kidney disease on daily life, mental component survey, and physical component survey). Real-time reverse transcription PCR (RT-PCR) analysis demonstrated significant upregulation in the expression of the LPA(1) receptor subtype, downregulation of LPA3, and no change of LPA2 or LPA4. By quantifying the curvature of human saccades and thereby revealing the shortcomings of these models, the present paper documents new constraints with which future models of the saccadic system must comply and allows certain suggestions on how these might be developed.

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The c-Met pathway has been found to be an important pathway in half of all patients with HCC. We investigated multiple infections in natural populations of the systemic fungal plant parasite Microbotryum violaceum, the anther smut of Caryophyllaceae, on its host, Silene latifolia. The diagnosis of viral infection is usually determined by viral cultures. Drinking patterns varied by gender, race, and rural residence in bivariate analysis. The main purpose of statistics in the analysis of clinical and epidemiological studies is to summarize data and information, as well as assess variability, trying to distinguish between chance findings and results that may be replicated upon repetition. We examined both adaptive and neutral genetic variations in 44 populations of I. Isolated skin ulcers due to Mycobacterium tuberculosis in a renal allograft recipient. Correlation and regression analyses were conducted to determine the strength of associations between BMD and clinical parameters.

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The study was conducted in a perennial tropical forest, over a period of 80 nights, a sampling effort of 73 200 mist-net-hour, from May 2006 to August 2007. Based on these findings and genome comparisons, it can be concluded that the massive genome decay in M. Gene regulation and aging are intrinsically linked and these links often reach directly to transcription factors and their actions in gene regulation. Decreased immunologic responsiveness following intensified vaginal immunization against urinary tract infection. At 8 weeks, the feedback group showed a significant decrease in drinks per week and peak BAC over control. Future trends may include a broader range of chemical tests as well as a better understanding of disease processes associated with microhematuria. Two patients are reported with cutaneous malignant melanoma who had been on treatment with cyclosporin A.

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Contrasting growth modes of Mn on Ge(100) and Ge(111) surfaces: subsurface segregation versus intermixing. Currently, the NCI uses the BRIDG model to support interoperable application development in the caBIG, and CDISC and HL7 are using the BRIDG model to support standards development. Lymph node T cells from rats immunized with OVA proliferate following 18 hr coculture with EC and OVA. The panel of designed HRM assays with direct reflex sequencing possibility provides an effective method for mutation screening of EGFR and K-ras genes in routine diagnostic specimens, thereby allowing the selection of the treatment of choice in clinical practice. Technical advances in detecting these interactions contribute to our understanding of the functional organization of the genome, as well as its adaptive plasticity in response to environmental changes during development and disease. In the physical model, sudden application of boundary heat fluxes in the boundaries is assumed. In this study, we have investigated the acute effects of testosterone on the level of expression of a key trigger for inflammation and innate immunity, Toll-like receptor 4 (TLR4), on isolated mouse macrophages. The survival of cocultured RGCs was significantly better than that of isolated RGCs.

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The model is validated in living human subjects and shows effectiveness in predictions for cadaver models. Human papillomavirus vaccine: an updated position statement of the Society for Adolescent Health and Medicine. We report the characterization of the spectral response of a wavelength-self-tunable single-sideband filter operating at 16-GHz radio frequency. Ultrastructural studies on experimental hair infections in vitro caused by Trichophyton mentagrophytes and Trichophyton rubrum. Potential usefulness of sevelamer hydrochloride to improve cardiac outcome in patients with coronary disease and normal renal function. Because of inconsistent study results there is a great amount of insecurity with respect to the reasonable diagnostic approach in such a scenario.

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A parallel implementation of the Cellular Potts Model for simulation of cell-based morphogenesis. Hepatitis C virus (HCV) often causes a persistent infection associated with hypergammaglobulinemia, high levels of antiviral antibody and circulating immune complexes, and immune complex disease. Phosphorylation of RUNX1 by cdks on serine 303 was shown to mediate destabilization of RUNX1 in G2/M. Captures of western corn rootworm (Coleoptera: Chrysomelidae) adults with Pherocon AM and vial traps in four crops in east central Illinois. TRALI was diagnosed clinically and immunologically by detection of reactive antibodies in a unit of fresh frozen plasma that had been administered to the patient. The apoenzyme of diol dehydrase was inactivated by photoirradiation in the presence of rose bengal or methylene blue, following pseudo-first-order kinetics. The developed baculovirus vector has a high transduction efficiency and the ability to mediate foreign gene expression in mammalian cells. In particular, continuous developments in imaging techniques have made radiologists become increasingly aware of this anatomical entity in recent years. At the same time, it decreases the general proteolytic activity and callicrein activity of blood serum for syngenic animals. Poor infection-control procedures are frequently implicated as contributing to ESBL spread.

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A comparative study of the breathing pattern and amount of nasopharynx obstruction by the pharyngeal tonsil in HIV infected and non infected children. Women were largely positive about participation in the trial and its follow-up, but still reported ways they believed the study could have been improved, such as more information, given earlier, which also has implications for clinical care. Long-term IOP fluctuation was defined as the standard deviation of IOP (millimeters of mercury) at all visits after initial intervention until the time of VF worsening or end of follow-up, whichever came first. Ascorbic acid and tetrahydrobiopterin: looking beyond nitric oxide bioavailability. Syncope as a symptom of non-massive pulmonary embolism: a case report. The J-bone graft is capable of creating a stable shoulder joint without causing extensive loss of motion on the long term in patients with traumatic glenoid rim fractures after shoulder dislocation. Importantly, subsequent analyses of this fiber revealed the improper folding of its scFv constituent. We show by direct resequencing of a approximately 6-kb region of chromosome 1 that the HapMap data are unreliable for this region. New choices for central venous catheters: potential financial implications.

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From our data on 6 specimens, three dimensional reconstructions were made of ventral views of the distribution of carotid body type 1 and 11 cells. This article reviews the background to the introduction of the pilot programme and describes the features and complications of MCADD, including the diagnosis and management. Reduction of the fibrotic area was observed in SHR treated with delapril and candesartan, although the latter was not statistically significant. Explanations may include more physically demanding occupations for men with low education levels and different attitudes toward body image between the sexes. An analysis of the factors responsible for the greater ketogenic response in the EHD rat reveals that moderate diabetes and dehydration enhance MCT-induced ketone body accumulation, while cortisol is without effect.

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In this work, we have demonstrated that it is possible to adjust the polarity of the zeolitic adsorbent to optimize its thermodynamic adsorption properties for the energetically relevant CO(2)/CH(4) separation process. This facilitates proton transfer from Glu46 to the chromophore in the dark by lowering the barrier, leading to the protonation equilibrium and causing the rapid light-induced proton transfer which couples the cycles. MGBG was preferentially bound to ribosomal RNA among ribosomal RNA, poly(U), and calf thymus DNA, and strongly inhibited the amount of polyamine bound to ribosomal RNA. The aim of the study was to investigate temporal trends in the initiation of GLM among patients discharged after first-time MI. The goals of this study were to quantify the rate and to identify predictors of compliance with outpatient hepatitis C evaluation. This effect was studied by application of serum samples to a beta-mercaptoethanol-blocked EC (EC-beta ME) column followed by analysis of proteins eluted with various elution buffers. Distribution of metoprolol, tramadol, and midazolam in human autopsy material. Our analyses indicate the presence in Cameroon of contemporary descendants of numerous early-diverging HIV-1M lineages. In the lower leg, values from load cells are compared to injury criteria developed in cadaveric studies.

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Breeding site on horse flies (Diptera, Tabanidae) in the vicinity of Izhevsk. An inverse correlation between TA dose and capsule thickness was noted. Nonwhite subjects, as opposed to white subjects, attributed greater sweetness to nutmeg and less sweetness to anise. Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon. 3) The predominant anticoagulant actihan in the inner layers referred to the concentration of glucuronic acid on thrombelastogram. Usually, this knowledge and the related skills can be best provided in consecutive B.Sc. The CT and the FDG-PET/CT were registered with a rigid and a non-rigid registration algorithm to compare the overlap between GTV contours defined with the following methods: manual GTV definition in (1) the CT image of the FDG-PET/CT, (2) the PET image of the FDG-PET/CT, (3) the CT study based on endoscopic clips (CT clip), and (4) in the PET-data using different semi-automatic PET segmentation algorithms including a gradient-based algorithm. This study evaluated the effect of resveratrol on cisplatin-induced kidney damage.

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Ninety-two patients underwent reflux symptoms evaluation, upper gastrointestinal endoscopy, and barium swallow X-ray before and 6 months after banded GBP. So far no cases of nephrogenic systemic fibrosis (NSF) have been published on macrocyclical gadolinium-based contrast media (Gd-CM), assumed as low NSF risk CM due to their complex stability. The role of sulfhydryl groups in the functioning of DNA-dependent RNA-polymerase. Glass slides containing 4608 cDNAs from the IMAGE library were spotted using robotic technology. In visual change detection tasks, providing a cue to the change location concurrent with the test image (post-cue) can improve performance, suggesting that, without a cue, not all encoded representations are automatically accessed. ASPD and the impulsivity/lifestyle features of psychopathy weakly predicted SRB. The observed differences are probably related to specific pattern of functioning of paired organs determined during embryogenesis. Protein interaction networks from divergent organisms may be compared to investigate how gene duplication, deletion, and rewiring processes have shaped the evolution of their contemporary structures. Patients should be divided into those who are at high risk and those who are at low risk for venous thromboembolism.

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Using a multimarker strategy in a model with age, serum albumin, history of coronary artery disease, brain natriuretic peptide and PlGF, patients with 2, 3 and 4 positive markers had a 3.82-, 5.77- and 6.59-fold higher risk of mortality or a cardiovascular event, respectively, compared to those with no positive markers. (China) were discussed and summarized mainly on typical high fever periods, merozoits and schizoon observation, antibody response. This is an argument for maternal nursing to reduce infant mortality. Genic methylation is strongly influenced by transcription: moderately transcribed genes are most likely to be methylated, whereas genes at either extreme are least likely. Ion transport in cotton seedling roots exposed to gamma-radiation.

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Amiflamine (2.5 and 5.0 mg kg-1, i.p.) increased in a dose-dependent manner total activity and to a lesser extent, locomotion when given 60 min before L-tryptophan (100 mg kg-1, i.p.). The diversity of these signals and the relative simplicity of the neural circuits controlling them make them a model well-suited for studying the mechanisms, evolution and sexual differentiation of behavior. Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH. This study was conducted to investigate the protective effect of Tongmai oral liquid on arteriovenous fistula function and to provide an effective method to promote fistula maturation. The effects of acute oral antioxidants on diving-induced alterations in human cardiovascular function. These two methods often yield similar results, suggesting that one can serve as a substitute for the other.

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The clinical value of stable mixed chimerism detection remains uncertain. Our findings on intermediate indicators of PSA screening provide encouraging, yet inconclusive evidence for eventual mortality reduction. Additionally, expression data have been used to identify oncogenic pathway deregulation to help direct the use of targeted agents. The changes singulair allergy medicine ingredients follow different time courses and suggest multiple mechanisms underlying the behavioural signs seen during the ethanol withdrawal syndrome. Effects of the inclusion of Equex STM into Tris-based extender on the motility of dog spermatozoa incubated at 5 degrees C. Unfortunately, the numerous clinical studies using this type of GES, with the exception of two, were not controlled and there is a need for definitive verification of the effectiveness of this technique to justify the cost and the risks of this procedure.

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A diagnostic complex consisting of most informative and accessible for the practical public health indicators is suggested. All compounds are insoluble in water and form aggregates in PBS with tetrahydrofuran as cosolvent. A histopathological examination and phosphotungstic acid hematoxylin staining demonstrated diffuse fibrin accumulation in the microvessels, while proliferating cell nuclear antigen staining showed a reduced nuclear stainability. During flight, the ocellar receptive fields of both nocturnal species are centred very dorsally, possibly in order to maximise sensitivity to the narrow dorsal field of light that enters through gaps in the rainforest canopy. The ERCC2 genotype appears as an important predictive factor of the survival of patients treated with oxaliplatin in first-line therapy for metastatic colorectal cancer. The dosage regimen of 300 mg Q12h intravenous infusion is recommended.

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The effects of tumor-derived platelet-derived growth factor on vascular morphology and function in vivo revealed by susceptibility MRI. It is experimentally and theoretically shown that the wavelength-dependent phase albenza dosing shifts in the gratings can be employed to remove the near degeneracy of the polarization mode beat frequencies of a given order, which substantially improves the resolution of the sensor. In this paper, we develop a hybrid particle swarm optimization (PSO) and tabu search (HPSOTS) approach for gene selection for tumor classification. Primary prevention of hypertension is possible through weight reduction, regular exercise, salt restriction and other dietary measures, but in developing countries is specially important to identify groups where a particular intervention is more effective and to improve detection and control of hypertension. Scientists continue to search for the cause of Tourette syndrome. Binding of SF and PB T cells to P-selectin was determined by flow cytometry using a soluble P-selectin/IgG1 fusion molecule. We investigated vitreous and serum levels of glucose and uric acid (UA) in patients with DR and aimed to describe their correlation with the grade of DR.

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The seizure induction time and duration were measured and lethal dose (LD50) and convulsant dose (CD50) of the clonic and tonic convulsion were calculated. Metastatic spine tumors affect a large number of patients each year, resulting in significant pain,destruction of the spinal column causing mechanical instability, and neurologic deficits. In order to delineate the potential usefulness of this drug, we have reviewed the preclinical data and summarized the Japanese clinical data on 462 patients. UCP1 is present in brown adipose tissue and has a well-documented role in cold-induced thermogenesis. During the 24-year follow-up period, 311 cases of cerebrovascular diseases occurred. Samples identified were those that reacted by automated gel technology and were negative with an FDA-approved reagent. During thousands of years humans were challenged by nutrient deprivation, developing an efficient mechanism to store energy. Maternal IgG anti-A/B titers have been considered as a susceptible factor to the risk of ABO hemolytic disease in newborn (ABO-HDN).

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Conservative surgical treatment is advocated when the diagnosis is confirmed by histological frozen sections. Methylenetetrahydrofolate reductase gene polymorphism, homocysteine and risk of macroangiopathy in Type 2 diabetes mellitus. Dehydration accelerates reductions in cerebral blood flow during prolonged exercise in the heat without compromising brain metabolism. A toxicologic and dermatologic review of alpha-isodamascone when used as a fragrance ingredient is presented. In experiments on anesthetized dogs it was shown that leukotriene biosynthesis block with quercetin essentially decreased cardiac and hemodynamic disturbances following the immune heart damage (intracoronary injection of anticardiac serum). The literature addresses the variant anatomy, and treatment options are discussed. Liposculpting and fat harvesting were performed with power-assisted liposuction.

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Variants of the human PPARG locus and the susceptibility to chronic periodontitis. The segmentation of cellular structures is achieved by first using an edge-preserving image filtering method for noise reduction and then applying an algorithm for cell shape reconstruction based on the Subjective Surfaces technique. Transfection of dominant-negative AMPA receptor subunit GluR1 to the tangentially migrating how many mg of klonopin to give a dog cells prevented the effects of AMPA on migration. Modeling the interaction of coils with the local blood flow after coil embolization of intracranial aneurysms. Transdermal delivery of a approximately 13 kDa protein--an in vivo comparison of physical enhancement methods. Among these, anti-tumor potentials of HTLV-I-specific CTL have been shown in ex vivo analysis of human HTLV-I-infected individuals and also in vivo experiments by using rat models of HTLV-I-infected lymphomas.

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It has been revealed that iodine deprivation leads to vegetative dystonia with the decreased activity of the sympathetic nervous system. We have demonstrated that several lots of commercial human serum albumin (HSA), prepared for clinical use by two manufacturers, reacted with anti-bovine whole serum in the double-diffusion test. Herein we show that the clinical use of in vivo staining is effective to define the superficial tumor borders and to detect malignant or pre-malignant cells in the surrounding area of the tumor following detection of a malignancy of the oral cavity. As a general alpha2 adrenergic antagonist, yohimbine has been widely used for research needs and in the therapy of malfunction of the noradrenergic system. Mixed-method observational analysis of the nature of the topics discussed, content of discussion, and the time spent on mental health. Four Strassmann operations for uterus septus of which one was followed by pregnancy and normal parturition. These immunoregulatory properties encouraged a possible use of these cells to modulate autoimmune responses in humans. Magnesium transporters, MGT2/MRS2-1 and MGT3/MRS2-5, are important for magnesium partitioning within Arabidopsis thaliana mesophyll vacuoles. Sar1 targeting to the axon followed axon specification and was dependent on localized actin instability. The dominance of one type of blackout over the other depends on operational conditions and the proximity of the system to one of its two critical points.

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Fluoxetine (3-56 mg/kg i.p.) and desipramine (1-30 mg/kg i.p.) produced marked, dose-dependent suppression of immobility time in both nondiabetic and diabetic mice. The expression of two genes coding for alkane-1-monooxygenase enzymes was highly upregulated in the presence of hydrocarbon substrates. At physiologically relevant concentrations mefloquine was found to mobilize neuronal ER calcium stores and antagonize the pharmacological action of thapsigargin, a specific inhibitor of the ER calcium pump. The addition of dexamethasone further enhanced extracellular matrix gene expression and protein synthesis. The emerging roles of BNP and accelerated cardiac protocols in emergency laboratory medicine. However, the levels of 7 amino acids showed significantly different alteration between atg5 and WT in the dark: 6 amino acids, particularly arginine and alanine, were much more deficient in the atg5 mutants, irrespective of the early degradation of Rubisco protein. The distributions of the WGA-HRP-labeled neurons and the degenerated axon terminals overlapped in the dorsal part of the Sg. ruminantium proteins encoded by the map1 multigene family, expressed in vitro in bovine endothelial and tick cell cultures. A fractal analysis of the spatial distribution of tumoral mast cells in lymph nodes and bone marrow. To understand the basis for this observation, we determined whether components of the pathway leading to IFN-beta induction were altered during infection.

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