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Cadol (Tramadol)

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Cadol is used to relieve moderate to moderately severe pain. Cadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Other names for this medication:
Anatram, Anazac, Cadol, Damadol, Dolodol, Dolomed, Dolriz, Doltel, Gemodol, Kevtram, Madol, Midol, Movon, Ondol, Opiran, Pacadon, Postadol, Rybix, Sayodol, Sigmadol, Simol, Tacil, Takol, Traiz, Tramacon, Tramospas, Tranat, Trandy, Trofel, Tromar, Tromfil, Ultracon, Urgendol, Zamadol

Similar Products:
Addyi, Acticin, Omnicef, Seroquel, Amoxil, Levitra, Cipro, Terramycin

Also known as: Tramadol


{name} ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Cadol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Cadol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Cadol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep in a tight light resistant container. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cadol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Cadol ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Cadol ER should not be given to a child younger than 12 years old. Cadol ER should not be given to anyone younger than 18 years old.

Do not give Cadol ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Cadol ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Cadol ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Cadol ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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PCPA seemed to interfere in the hypophyseal-adrenal axis: these hamsters lowt the most weight, pituitary glands were enlarged and some hyperactivity occurred in the hamsters. Two RNA-binding sites have been characterized: the proximal site which binds sRNA and mRNA and the distal site which binds poly(A) tails. Atypical forms of spinal tuberculosis have been described and are most often a result of posterior element involvement. Defining the quantitative contribution of the melanocortin 1 receptor (MC1R) to variation in pigmentary phenotype. The model is analyzed in terms of optimizing the one-stage continuous cultivation process. Magnetic resonance imaging demonstrated hyperintense lesions in the infratentorial and parieto-occipital regions consistent with posterior leucencephalopathy syndrome. Five-year clinical outcomes after coronary stenting of chronic total occlusion using sirolimus-eluting stents: insights from the rapamycin-eluting stent evaluated at Rotterdam Cardiology Hospital-(Research) Registry.

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Two new brassinosteroids, (22R,23R,24S)-22,23-dihydroxy-24-methyl-5alpha-cholest-2-en-6-one (secasterol) and (22R,23R,24S)-22,23-dihydroxy-2alpha,3alpha-epoxy-24-methyl-5alpha-cholest-6-one (2,3-diepisecasterone) have been identified together with a known 2,3-epoxybrassinosteroid, secasterone, in seedlings of Secale cereale. Different clinical types of algae-related poisoning have attracted scientific attention: paralytic shellfish poisoning (PSP), diarrhetic shellfish poisoning (DSP), and amnesic shellfish poisoning (ASP). Chemical inhibitors of calmodulin phenocopy the mutant FcRn defect in transcytosis. Solarium-induced pseudoporphyria and variegate porphyria as rare differential diagnoses of porphyria cutanea tarda. These results underscore the high prevalence of the BI epidemic strain and demonstrate that mild to moderate CDI infection as well as severe disease can be caused by these strains.

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The development of a knee locker with closed-loop functional electrical stimulation (FES) for hemiplegia in gait training. Van Gieson staining and collagen type I immunostaining showed that the pellet contained collagen fibers and cells that adhered to the collagen fibers. Accuracy of 2-Phase Parathyroid CT for the Preoperative Localization of Parathyroid Adenomas in Primary Hyperparathyroidism. To clarify the mechanisms for the metabolism of monoamines in rat striatum, highly specific MAO-A and -B inhibitors were used in the following experiments. In view of this selective action the McN-A 343-pirenzepine interaction was studied, the latter being classified as an M1-selective antagonist. We further identified epistatic interactions responsible for the observed allometric variation. Diagnostic specificity of dynamic assessment and monitoring of spirometry in asthma. Effects of parity on pregnancy hormonal profiles across ethnic groups with a diverse incidence of breast cancer. Incubation of Chinese hamster cells with labelled caffeine leads to transfer of radioactivity to DNA.

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Blastomyces dermatitidis produces melanin in vitro and during infection. To date the changes that have been studied are as a result of being embodied in a body representative of particular social groups (e.g., children and other race). To respond to these emergencies, it is important that obstetrician-gynecologists prepare themselves by assessing potential emergencies that might occur, creating plans that include establishing early warning systems, designating specialized first responders, conducting emergency drills, and debriefing staff after actual events to identify what went well and what are opportunities for improvement. Thirty patients underwent wet liposuction and were submitted postoperatively to a 24-h noninvasive monitoring control of vital signs. Gene expression-based classification and regulatory networks of pediatric acute lymphoblastic leukemia. LV pressure, meridional wall stress (sigman), wall thickness (h), and radius (R) were measured in each patient throughout the cardiac cycle. Quantifying effects of seedborne inoculum on virus spread, yield losses, and seed infection in the pea seed-borne mosaic virus-field pea pathosystem. Ab initio molecular orbital calculations were performed using Hartree-Fock, MP2, and density functional theory methods to determine the most likely mechanisms of molecular imprinting. Necrotizing enterocolitis in a term neonate following intravenous immunoglobulin therapy.

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Functional analysis of a cortical and fibrillar actin system by use of fluorescent-analog cytochemistry. In particular, Oxa has been characterized in terms of its formation and mechanism of DNA-protein cross-link (DPC). Acyclovir dosage for neonatal herpes and duration for herpes encephalitis in adults. On the origin of certain serum peptidases as indicated by experimental hemolytic anemia in dogs. Anticipating loss and zybend albendazole tablets uses in hindi other temporal stressors predict traumatic stress symptoms among partners of metastatic/recurrent breast cancer patients. There was perfect rank correlation between the mean number of cases starting during each 12-h period and appropriate staffing during the 12-h period, whether quantified by total hours of cases or by the under-utilized and over-utilized OR time resulting from staffing decisions.

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Fathers, sisters and brothers: shifts in power and rights in 19th-century property reforms. This descriptive analytic study conducted in patients, who have undergone percutaneous endoscopic gastrostomy tube placement during January 1998 till December 2004. Our data suggest that the various how do you take levaquin 500 mg processes contributing to generation of ROI are closely linked. The vascular model developed was able to predict the cooling produced by the blood vessels in the region where the vessels were present. The effects of ketamine on SNL-induced mechanical allodynia were confirmed by behavioral testing. An anonymous questionnaire was distributed to physicians and qualified nurses working in a, tertiary hospital, seven primary care centres and two nursing homes (health care centres for the elderly). All isolates were also resistant to ciprofloxacin and gentamicin and had substitutions in GyrA and carried an aac(3)-II gene. An AFI 5 cm or less was considered oligohydramnios, 5-8 cm was considered borderline, and more than 8 cm to 24 cm was considered normal.

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The myocardial performance index is largely dependent on changes in preload. These were either located on the alpha- or beta-subunit or expressed only by the conformationally intact molecule (c-epitopes). It also indicates the factors that predict good adherence to health regimens. A case series of 954 cancer patients treated at the Cancer Treatment Centers of America was investigated. The present study evaluated the efficacy of nasal turbinate surgery with RF for the treatment of nonallergic rhinitis in elderly patients refractory to medical therapy. Complement: structure, functions, evolution, and viral molecular mimicry. Structure determination, apoptosis induction, and telomerase inhibition of CFP-2, a novel lichenin from Cladonia furcata. Cannabinoids in the management of intractable chemotherapy-induced nausea and vomiting and cancer zyrtec 10 mg 20 tabletek -related pain. A self-report questionnaire was administered to 1,509 nursing personnel at two Brazilian hospitals.

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