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Bonestat (Calcitriol)
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Bonestat

Bonestat is an active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia. Bonestat is a biologically active calcitrophic hormone with anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities.

Other names for this medication:
Alcee, Alfabond, Aristrol, Biocal, Bonestat, Calbovic, Calcibest, Calcicare, Calcit, Calcitriol, Caldix, Calfa, Calsure, Caltin, Calzem, Duracal, Ikmag, Koncal, Kurecal, Netxod, Novadee, Nutribone, Osteobel, Primacal, Refirm, Romical, Solbiocal, Sorvate, Zaxial

Similar Products:
Klonopin, Levothroid, Cenforce, Xalatan, Lodine

Also known as: Calcitriol

Description

Generic Bonestat is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Bonestat are intestine and bone. Generic Bonestat receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Bonestat may also act on the kidney and the parathyroid glands. Generic Bonestat is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Bonestat has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Bonestat, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Bonestat in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Bonestat produces other independent beneficial effects. Bonestat is also known as Calcitriol. Generic Bonestat treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Bonestat is Calcitriol. Brand name of Generic Bonestat is Bonestat.

Dosage

Generic Bonestat is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Bonestat suddenly.

Overdose

If you overdose Generic Bonestat and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bonestat are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Problems in children have not been reported with intake of normal daily recommended amounts. Some studies have shown that infants who are totally breast-fed, especially with dark-skinned mothers, and have little exposure to sunlight may be at risk of vitamin D deficiency. Your health care professional may prescribe a vitamin/mineral supplement that contains vitamin D. Some infants may be sensitive to even small amounts of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol. Also, children may show slowed growth when receiving large doses of alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, or ergocalciferol for a long time.

Studies on doxercalciferol or paricalcitol have been done only in adult patients, and there is no specific information comparing the use of doxercalciferol or paricalcitol in children with use in other age groups.

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Thyroperoxidase and thyroglobulin antibodies in early pregnancy and placental abruption. Current use patterns would indicate that GRCs will likely continue to be a popular weed management choice that may also include the use of other herbicides to complement glyphosate. Phase measurement for surface infrared-visible sum-frequency generation. These results suggest that COX-1 is the principal isoform responsible for prostaglandin production in the mouse eye. The authors present a case report of a 70-year-old woman who presented with delayed symptoms of epidural hematoma after epidural catheter anesthesia. This structure is consistent with other known mammalian TCRbeta-chain loci.

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Limits are to be imposed on the amount of money that many NHS organisations can spend on agency staff, it was announced last week. Rifapentine is a long-lived rifamycin derivative currently recommended only in once-weekly continuation-phase regimens. Genetics of the lipoprotein lipase gene and hypertriglyceridaemia. Mg-dependent ATP-ase, alkaline phosphatase and carbonic anhydrase activities were tested at the level of capillary endothelia of alveolar walls in normal rabbits. Mature cystic teratoma is a common benign adnexal tumor in females. Rare and Severe Maxillofacial Injury Due to Tear Gas Capsules: Report of Three Cases.

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Our results suggest that functionally relevant IRF-1 polymorphisms influence atopy risk, potentially by altering transcription factor binding, IRF-1 gene expression, and IFN-gamma regulation. The goal of the current study was to examine the stability of symptoms of ASD between two assessment times for 114 toddlers. The alteration of heparin-binding properties of SF also was observed upon exposure of the protein to heat or acid. High-power femtosecond-pulse reshaping near the zero-dispersion wavelength of an optical fiber. To study the adipokines concentration and glucose homoeostasis in the early-second trimester of women who will develop gestational diabetes mellitus (GDM). Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: initiation of fimbria carcinogenesis. Moreover, we show that human monocyte-derived dendritic cells harbor inactive proforms of AEP that become activated upon maturation of dendritic cells with lipopolysaccharide. This histochemical study establishes the cartilaginous nature of the developing deer antler, defines some of the mucosubstance constituents involved in the chondrogenic and calcification process, and confirms the utility of the antler as a model for chondrogenic and calcification studies. However, neurologic complications are a common, significant, and under-recognized contributor to patient morbidity and mortality. Severe giant cell arteritis associated with essential thrombocythaemia.

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Reduced accumulation of the endogenous protoporphyrin IX and the exogenous hypericin and MC540 was detected in differentiated cells. Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants. Higher-category pressure redistribution mattresses are considered a critical component of a pressure ulcer prevention program, but few studies have quantified the impact of specific preventive measures on the incidence or prevalence of hospital-acquired pressure ulcers (HAPUs). Three drug reviews: one reformulated and one new antifungal agent and optimal dosing of the anticonvulsant gabapentin. Secondary end points were changes in American Urological Association subset scores, Boyarsky symptom scores, average urine flow rate, post-void residual urine volume, quality side effects of elavil 25 mg of life index and investigator global assessment. In real systems, such a stage would correspond to times of the order of a few microseconds after the initial contact.

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Each layer consists of various components with a specific structure. Noise exposure assessment and abatement strategies at an indoor firing range. This assumption was tested by quantifying the metabolic rates of turfs and herbivorous gastropods under a series of elevated temperatures in which the ensuing production and consumption were observed. Rheumatoid arthritis synovial membrane contains a 62,000-molecular-weight protein that shares an antigenic epitope with the Epstein-Barr virus-encoded associated nuclear antigen. Coxsackievirus is the most prevalent virus associated with the pathogenesis of myocarditis and its sequela dilated cardiomyopathy. There is tenuous evidence that moderate alcohol consumption may protect bone. Role of splenectomy in patients with refractory or relapsed thrombotic thrombocytopenic purpura. The overall study group comprised 21 patients with PTC who underwent robotic SND via a unilateral transaxillary approach for treatment of suspicious lymph node metastasis in the lateral compartment. By gene transfer experiments, it was possible to construct isogenic pairs of strains that differed only with regard to the presence or absence of pAM539.

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Determination of a correction to improve mass measurement accuracy of isotopically unresolved polymerase chain reaction amplicons by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Using the Mauk Model for Poststroke Recovery, nurses can identify which phase of recovery a survivor is in, and thus tailor care to his or her needs. A PRx value of less than 0.3 indicates intact cerebral vasomotor reactivity, and a value of more than 0.3, impaired reactivity. In addition, our proposed procedure is nonparametric in the sense that the variables can have distributions deviating strongly from normality: it makes use of quantile normal scores to transform to normality, performs imputations, and transforms back to the original scale. It is interesting that the energy involved for such distortions is only kBT, allowing several polymorphic forms of the crystal structure as reported in linezolid brand name the literature.

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Relationship between instrumental activities of daily living and blood glucose control in elderly subjects with type 2 diabetes. This made it possible to compare directly the mechanism of repair between yeast and mammalian cells for the same type of induced DSB. The influences of glucose, sorbitol, and NaCl in a basal enumeration medium at water activities (aw) from 0.82 to 0.97 on colony formation by sublethally heat-stressed Wallemia sebi conidia were determined. Characterization of mitochondrial DNA from the pika (Ochotona rufescens rufescens). Maturation and trafficking markers on rotavirus-specific B cells during acute infection and convalescence in children. The mitotic spindle plays an essential role in chromosome segregation during cell division. In this study we identified the correlations between early cancer-associated genome DNA-hypomethylation, nuclear morphometric changes, somatic chromosomal ploidy status and the proliferation index. Particles in the fraction with peak DNAP activity had a buoyant density of 1.16 g X cm-3 in sucrose and an estimated sedimentation coefficient, S20.w of 77. Additional details and explanations have been given in the accompanying notes. To (1) analyze the financial returns of fellowship training in pediatrics and to compare them with those generated from a career in general pediatrics and (2) evaluate the effects of including the newly enacted federal loan-repayment program and of changing the length of fellowship training.

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