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Bludol (Tramadol)

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Bludol is used to relieve moderate to moderately severe pain. Bludol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Other names for this medication:
Adamon, Antram, Armadol, Arrestadol, Bestodol, Bolodol, Cadol, Cemadol, Cosdol, Dolex, Drobit, Esgiypyrin, Haledol, Kevtram, Moludol, Movon, Mydol, Neutram, Nictram, Nobligan, Paxmax, Ramax, Relidol, Servodol, Tramadex, Tramatas, Tramazol, Tramoflex, Tranat, Trandol, Trapain, Trydol, Urogendo, Vegadol, Vintram, Xidol, Xtram

Similar Products:
Parlodel, Benemid, Periactin, Lipitor, Zovirax, Klonopin, Rulide

Also known as: Tramadol


{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Bludol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Bludol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Bludol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bludol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how Bludol ER will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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In this study, we found a novel variant (1267 G to A) in exon 10 of the CHRNA7 gene in a Japanese population. Although the role of the objectively and subjectively rated severity of appearance problems is often debated, the impact of severity upon psychological adjustment has yet to be explored fully. The rhizomes of Kaempferia parviflora (KP) (Zingiberaceae) have been used in Thai traditional medicine for health promotion and for the treatment of digestive disorders and gastric ulcer. Salvage radiotherapy for refractory abdominal NHL is a feasible alternative for both follicular and diffuse subtypes and may provide significant palliation and prolongation of survival. In this review, we summarize the sometimes contradictory findings regarding those markers which influence the progression of gastric adenocarcinoma. Three patients with obstructive dacryocystitis and benign melanosis were African-Americans whose sacs disclosed the presence of nonclustering, melanoma antigen recognized by T cells, and microphthalmia-associated transcription factor-positive intraepithelial dendritic melanocytes at all levels of the epithelium. The up regulation of FLRG in IDC suggests a role for this protein in the progression of breast malignancy. Conditioned fear is a standard feature of this habituation paradigm, serves to potentiate the startle response, and provides an associative dimension lacking in the habituation process per se. Within a short period of time, from 2 days up to 6 months after operation the 7 remaining cases represented marked tracheal stenoses with the mucosae showing no signes of irritation.

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There is a good chance that epigenetic therapies will be able to be used in patients with solid tumors in the future. An Emergency Department (ED) computerized record system and hospital records were used to obtain data on children who presented to a paediatric ED with mental health problems. Differing brain structural correlates of familial and environmental risk for major depressive disorder revealed by a combined VBM/pattern recognition approach. Seven fetal larynges obtained from 28- to 36-week-old fetuses were analyzed with the Picrosirius-polarization method, immunohistochemistry, and image analysis. The artificial neural network recognized patterns in functional outcomes and provided a set of relationships between ELP formulation parameters and measured outcomes. After administration of several units of packed red blood cells and fresh frozen plasma, a gradual decline in oxygen saturation was observed. Previously, we have shown that nucleosomes formed on very strong positioning sequences (601 and 603), present a high, orientation-dependent barrier to transcription by RNA polymerase II in vitro. Low tidal volume (VT) ventilation is recommended in patients with acute respiratory distress syndrome (ARDS). ISH for the recipients with HCV may be useful for predicting the response to interferon therapy. Dynamics of the loss of pulmonary function in patients with silicosis--a retrospective analysis by experts.

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Carboplatin concentrations in the blood plasma were found to be significantly higher after intravenous delivery than after focal delivery by subconjunctival injection or CCI. The device consists of a 2-cm-thick CS(2) cell at the first focus and a reverse saturable-absorber dye in a thin cell (0.1 mm) at the second focus. The defect in mutant 34Cts was apparently due to a single gene mutation, and was recessive in heterokaryons. Radioimmunoassay of human platelet thrombospondin: different patterns of thrombospondin and beta-thromboglobulin antigen secretion and clearance from the circulation. Trigeminal Nerve Stimulation (TNS) for Major Depressive Disorder in Pregnancy: A Case Study. 60-year old woman with round lesion of the right upper lobe of the lung after heart transplantation. Natural killer cell is a major producer of interferon gamma that is critical for the IL-12-induced anti-tumor effect in mice. Early diagnosis is facilitiated by the battery of auditory tests comprising behavioural, impedance audiometry and auditory brain-stem response audiometry. Development of abdominal fat and incipient metabolic syndrome in young healthy men exposed to long-term stress.

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5-(Phosphonomethyl)-1H-tetrazole and a number of related tetrazoles have been prepared and their effects on the replication of Herpes Simplex Viruses-1 and -2 have been investigated as well as their abilities to inhibit the DNA polymerases induced by these viruses and the RNA transcriptase activity of influenza virus A. A current issue in research of breast self-examination (BSE) efficacy is the competency of BSE performance. We have evaluated the efficacy and clinical impact of FDG-PET for staging patients with potentially resectable non-small cell lung cancer (NSCL) in CT. Our results show that patients with corrosive injury have prolonged OCTT even in the absence of any gastric symptoms. Results showed that the rate of CR was positively related to the amplitude of the UR, but was not affected by emotional pictures or by physiological arousal.

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Echinococcosis continues to be a severe public health problem in this part of China because of unhygienic practices/habits and poor knowledge among the communities regarding this disease. Until additional information is available, the use of fish-oil supplements for treatment or prophylaxis of cardiovascular disease is not warranted. In this study, we investigated whether NGF can be released from fibrin gel for a long period in a controlled manner. The authors described a 5-year-old girl with congenital afibrinogenemia who presented with nonketotic hyperosmolar coma associated with spontaneous splenic rupture. In 121 patients (35 per cent), the ventricular septal defect was enlarged by excising a portion of the septum.

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The principal modifiable risk factors for necrotising enterocolitis (NEC) in very low birth weight infants relate to enteral feeding practices. These data suggest that inflammation and endothelial dysfunction may play a role in the cause of hypertension. Camel bone charcoal is used as an adsorbent for the removal of Hg(II) from wastewater effluents. This case underscores the importance of having a high suspicion for the presence of an intracranial injury and a retained foreign body in the setting of a penetrating head injury. Evaluation of participant satisfaction at the end of the pilot program used e-mail questionnaires. In conclusion, Lcn2 significantly promoted human pulmonary artery smooth muscle cell proliferation by activating PI3K/Akt pathway. Evaluation of effectiveness of combined sewer overflow control measures by operational data. We show that the phiBT1 integrase can be used in conjunction with Cre recombinase to promote the iterative integration of transgenic DNA. Evaluation of bone healing with eggshell-derived bone graft substitutes in rat calvaria: a pilot study.

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At five and seven days the control wounds were 10 times stronger than those of the treated animals, and at 10 days they were four times stronger. The resulting structures are combinations of known secondary structures. These findings suggest that the expression of TAZ protein is involved in osteoblast proliferation and differentiation. Applications for patents that were subsequently granted per albendazole 400 mg where to buy medical school faculty increased dramatically during the period from 1981 through 2000. Emergency endovascular repair of acute thoracic aortic dissection is feasible and relatively safe. EFDs are a general risk factor for poor cognitive functioning across multiple domains, irrespective of diagnostic status.

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The photodynamic therapy (PDT) efficacy was determined at different drug administrations to light intervals and correlated with the tumour and plasma pharmacokinetic data. The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. A total of 4 patients underwent early valve replacement successfully because of severe heart failure. The syndrome usually progresses to the point where long term institutional care is needed although the mean survival from onset is 13 years. For DPPC/GTO layers a similar trend in the energy changes as a function of GTO amount was observed.

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TREATMENT OF RAGWEED HAY FEVER WITH ALUM PRECIPITATED PYRIDINE COMPLEX EXTRACTS. During crystal growth, the number of nanoparticles decreased gradually but their size was constant. Analysis of storage lipid accumulation in Alcanivorax borkumensis: Evidence for alternative triacylglycerol biosynthesis routes in bacteria. Variability that affects carrying capacity or adult reproductive rate has negligible effects on the fitness associated with care. Does ovarian suppression offer superior benefit to standard therapy in the treatment of premenopausal breast cancer?. Truncation analysis showed that ERRbeta-mediated p21 transactivation and prostate cancer cell growth inhibition what is the highest dosage of effexor you can take required intact DNA-binding domain and AF2 domains in ERRbeta. This is achieved by replacing the acquisition dimension in the original experiment with a train of equally spaced pi-pulses.

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Central chemosensitivity is critically important to maintain homeostasis. The NO level was 3.5-fold higher in control (nondepleted) explants than in auxin-depleted ones. Given these values, one can also modify the dendrogram by combining non-significant branches. Furthermore, DCXR expression at the protein level was assessed using fresh-frozen tissues and a tissue microarray consisting of 46 cases of organ-confined early-stage prostate cancer and 29 cases of chemohormonally treated prostate cancer. The apoptosis regulator Bcl-2 has been shown to modulate cell-cycle progression, favouring a quiescent state over a proliferative state, in both normal and tumour cells. Patients with bladder exstrophy and failed primary newborn closure or who undergo delayed primary repair have suboptimal functional outcomes. In these cases, the values of urinary hydroxyproline creatinine ratio were more reliable. Understanding the mechanisms involved in gap junction-mediated neuronal injury due to hypoxia will lead to the development of novel therapeutic strategies.

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Seventy-two hours after the application of tests, PPD indurations were measured. This study measures neutral protease activity with a quantitative viscometric assay throughout all zones of the bovine growth plate. In harvesting the PM flap, the pectoralis minor muscle is divided to preserve the lateral thoracic artery and its blood supply to the lateral distal skin island of PM flap without compromising the pedicle length for head and neck reconstruction. Technical skill is only one component of overall surgical competency, but it has been one of the most difficult to measure. In natural systems, individuals are often co-infected by many species of parasites. The amino acid sequence HAV in the extracellular domain of N-cadherin is required for N-cadherin-mediated adhesion and migration. Corticotrophin-releasing hormone (CRH) is the hypothalamic peptide that controls the function of the pituitary-adrenal axis in response to stress. The nutritive value of the caviar of whitefish from Siberian reservoirs. Detection of human metapneumovirus from wheezing children in Japan. Moreover, the magnitude of responses in both regions was positively correlated for gains and losses, across participants, while an independent reward-sensitivity covariate predicted the relative difference between and gain- and loss-related activation on self-directed trials.

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We evaluated the clastogenic and/or genotoxic potential of fruit pulp extract prandin class of medication of this plant in vivo in peripheral blood and liver cells of Wistar rats, using the comet assay, and in bone marrow cells of Swiss mice, using the micronucleus test. We retrospectively reviewed the Memorial Sloan-Kettering breast cancer surveillance program prospective database from April 1999 to July 2006. These observations indicate that GDF-5 stimulates osteogenic differentiation and has a potential to induce angiogenesis through osteoblast-derived VEGF-A in bone. The standard components of CBT for depression are useful in treating comorbid depression in post-MI patients. A huge saccular idiopathic dilatation of the right atrium was detected with angiography and echocardiography in a 75 year old man. Structure-activity relationship of rubiscolins as delta opioid peptides. Six weeks later the animals were reanesthetized, and the diaphragmatic stab wounds were examined at laparotomy. In this article, we present a general multivariate, longitudinal mixed-model that incorporates the complex grouping structures inherent to longitudinal student data linked to teachers.

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Dendritic spine density and proportions of the different spine types on Purkinje cells was assessed in the cerebellar simple lobule, as was drebrin A expression. The importance of paraclinical indices, therapeutic and other factors for the late treatment results and prognosis in stage-Ib cervical cancer. Proliferation and hyperplasia of vascular endothelium in human skin. We here present a saturated linkage map and match it periactin dose with the Apis mellifera genome using homologous markers. Functionalized hydrogel surfaces for the patterning of multiple biomolecules.

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