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Bigesens (Metformin)

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Bigesens is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain and is taken by mouth.

Other names for this medication:
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Also known as: Metformin


{name} (metformin) is an oral diabetes medicine that helps control blood sugar levels.

{name} is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

{name} is sometimes used together with insulin or other medications, but metformin is not for treating type 1 diabetes.


Bigesens can be taken in form of pills and extended-release pills which should be taken by mouth. It is better to take Bigesens every day at the same time with meal or without it. Usual Bigesens dosage is taken 2-3 times a day with meals. Bigesens XR (extended-release tablets) is taken once a day with evening meal. Take Bigesens and remember that its dosage depends on patient's health state. Bigesens can't be used by patients under 10 years. Bigesens XR (extended-release tablets) can't be used by patients under 17 years. It can be dangerous to stop Bigesens taking suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bigesens are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Bigesens if you are allergic to metformin, or if you have:

severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Bigesens. Be sure your caregivers know ahead of time that you are using this medication.

Tell your doctor if you have ever had:

kidney disease (your kidney function may need to be checked before you take this medicine); high ketone levels in your blood or urine; heart disease, congestive heart failure; liver disease; or if you also use insulin, or other oral diabetes medications.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using Bigesens if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. Tell your doctor if you become pregnant while taking Bigesens.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while using this medicine.

Bigesens should not be given to a child younger than 10 years old. Bigesens XR is not approved for use by anyone younger than 18 years old.

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Parameters of arthritis activity in double-blind studies on pollen therapy in rheumatoid arthritis. Expressions for the gradient waveform, based on slew and amplitude limits, are developed such that a desired pitch in the spiral k-space trajectory is followed. Factor analysis of medical image sequences (FAMIS) applied to gadolinium chelate-enhanced subsecond magnetic resonance (MR) imaging was evaluated as a postprocessing method for assessing myocardial perfusion in coronary artery disease (CAD). Our results suggest that activation of p38 MAPK is an important component controlling neurogenic inflammation within the CNS independently from NF-kappaB. The purpose of this study was to identify independent predictors of vertebral fracture progression and the development of future vertebral fracture. D1 dopamine receptor: a putative neurochemical and behavioral link to cocaine action. Treatment of type III tibial intercondylar eminence fractures in skeletally immature athletes. We summarize the history of this family-centered community building movement and discuss how it builds upon and differs from earlier approaches to community development. Conventional lymphography is superior to lymphoscintigraphy and is usually required to document disruption of the thoracic duct.

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In view of the complexity of chronically ill VAIs, complications of mechanical ventilation become the major impediment in achieving the ultimate goal of LTMV, extending life, and improving psychophysiologic function and quality of life. This work aims at mathematically simulating the changes in the land use, by implementing an artificial neural network (ANN) model. Broken heart syndrome, neurogenic stunned myocardium and stroke. The common practice of allowing untrained sub-interns to perform handoffs as part of a required clerkship raises safety concerns. Their presence is associated with improved recurrence-free survival. Stable isotope labeling of amino acids in cell culture (SILAC) was used to quantify the coordinate effects of cytokine stimulation on NOS2-protein interactions. A new approach to CNS repair using chimeric peripheral nerve grafts. We showed that neither post-natal human dental pulp stem cells (DPSCs) nor stem cells from human exfoliated deciduous teeth (SHED) possess odontogenic potential or are odontogenic-competent. This article describes the non-pharmaceutical procedures which have an influence on perioperative and posttraumatic pain in children and adolescents. Smoking and alcohol consumption are independently associated with elevated ALT levels among anti-HCV-seropositive individuals but not among HBsAg-seropositive individuals.

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Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism. The fistulae were treated successfully in all patients, with functional restoration in four, and/or diversion of the gastrointestinal and urological tracts in six. Experiment of clinical use of sigetin in the treatment of intra-uterine asphyxia of fetus. Effect of early surgery in high surgical risk geriatric patients with femoral neck fracture and taking antiplatelet agents. hTid-1 specifically suppresses serine phosphorylation of IkappaBalpha by activated IkappaB kinase beta (IKKbeta), but the activities of other serine kinases including p38, ERK2, and JNK1 are not affected. We examined how the depth of coverage (the number of mapped reads) changed the number of detectable miRNAs in each sample type. When observing a dance-like action, it is likely that static snapshot images of body posture will be retained alongside dynamic images of the complete motion. Previous genetic analysis of Caulobacter crescentus showed that the periodic synthesis of hook protein, flagellin A, and flagellin B, the major flagellar subunits, is coupled in some way to chromosome replication. The patient had been previously treated with multiple topical corticosteroids and antifungals, all with minimal improvement. Significant differences in spatiotemporal symmetry ratios were not found over time.

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Using a practical approach for determining the most effective stretching strategy in female college division I volleyball players. History counts: a comparative analysis of racial/color categorization in US and Brazilian censuses. The aim of our study was to investigate whether stem cell (SC) therapy with human amniotic fluid stem cells (hAFS, fetal stem cells) and rat adipose tissue stromal vascular fraction cells-GFP positive cells (rSVC-GFP) was able to produce favorable effects on skeletal muscle (SM) remodeling in a well-established rat model of right heart failure (RHF). The hypersensitivities were probably mediated via D1/D2 receptors. The human fetal cell line RPE 28 SV4 has been useful for studies of oxidative stress and apoptosis in retinal pigmented epithelium.

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Skeletal open bite associated with bimaxillary dento-alveolar protrusion, evaluation and treatment. Pulse-chase and cycloheximide-chase assays demonstrated that the marked reduction in the co-transporter protein levels was essentially due to increased protein degradation of the immature form of NKCC2. The use of fluoroquinolones to treat pseudomonas infections has focused attention on topical therapy for external otitis and single-drug oral therapy for skull-base osteomyelitis, which arises as a complication of external otitis. 16 RCTs were identified through a search of Embase, Medline (OvidSP) and the Cochrane Library. Outbreak of bacterial conjunctivitis at a college--New Hampshire, January-March, 2002. Strikingly, T-cell responses against oncoproteins were exclusively present in patients with MCC, but not in healthy donors. Patients controlled by medical therapy were safely treated under administration of an effective drug prior to treatment, while patients with a cardiac pacemaker were examined and checked on the apparatus before tooth extraction by their own specialist. The validity of the method is established by comparing the results of Monte Carlo simulations to traditional Ginzburg-Landau minimizations of the free energy using a finite difference scheme, and its usefulness is demonstrated in the context of simulations of chiral liquid crystal droplets with and without nanoparticle inclusions. Cryptococcal infection of the larynx simulating laryngeal carcinoma.

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Vitamin D supplementation and body weight status: a systematic review and meta-analysis of randomized controlled trials. Laboratory exercise for teaching dental electrosurgery in restorative dentistry. The structures of Salmonella CheR and the methyl-accepting domain of the serine receptor (Tsr) from E. We have developed a microsphere-based system to rapidly measure levels of insulin and insulin analogs. The findings showed that hooks impose additional stresses on the vertebrae. The prevalence of antisense RNA in eukaryotes is not known and only a few naturally occurring antisense transcripts have been assigned a function. This article, dedicated to the memory of the late professor Raimond Castaing, will evoke the birth and the first developments of electron probe microanalysis in France.

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To determine the ontogeny of CRF receptors during adolescent development, three regions of the DR (dorsal, caudal, and ventrolateral parts) and the posterior VTA were microdissected from Sprague-Dawley male and female rats on postnatal day (P) 25, P35, P42, P56, and P90. N-methyl-D-aspartate receptors mediate chemoreflexes in the shorthorn sculpin Myoxocephalus scorpius. Interbands of polytene chromosomes: binding sites and start points for RNA polymerase B (II). Role of AMPA and GluR5 kainate receptors in the development and expression of amygdala kindling in the mouse. The distribution of types of mutation in mendelian disease genes argues for serious consideration of the early application of a genomic-scale sequence-based approach to association studies and against complete reliance on a positional cloning approach based on a map of anonymous single nucleotide polymorphism haplotypes. Study of respiratory arrhythmias and dysharmonies in cardio-renal insufficiency (polypneumographic research in the study of diaphragmatic and costal respiration). METHODS for the investigation of the sensitivity of bacilli to anti-bacillary agents. Targeted disruption of the endothelin-B-receptor gene attenuates inflammatory nociception and cutaneous inflammation in mice.

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The relationship between the self-report BASC-2 validity indicators and performance validity test failure after pediatric mild traumatic brain injury. A semi-automatic plaque assessment algorithm in repeated low radiation dose coronary CTA allows for high reproducibility of coronary plaque characterization and quantification measures. Separate mechanical processes underlie fast and slow effects of medial olivocochlear efferent activity. aureus contains RelA and SpoT proteins, similar to those produced by E. The immunoadsorbent was prepared by coupling sheep anti-(human leukemic lysozyme) IgG to epoxy-activated Sepharose 6B. Liposomes radiolabeled with gamma emitters such as (67)Ga, (111)In and (99m)Tc, can be used for imaging purposes. The findings provide preliminary support for telephone-delivered CBTI in the treatment of chronic insomnia. In the survey group the average number of FNAs performed per month was 4.7 per respondent practitioner.

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Exploring in integrated quality evaluation of Chinese herbal medicines: the integrated quality index (IQI) for aconite. Metagenomic sequences of solid (fiber adherent microbiota) and liquid (fiber free microbiota) fractions obtained using Ion Torrent PGM platform were analyzed using MG-RAST server and CAZymes approach. More recent trials have demonstrated that perioperative chemotherapy before and after surgery provides a survival advantage. Alcohol use and dependence are complex societal problems, which need to be viewed through multidisciplinary approaches and corrected by adopting intersectoral efforts involving local communities. fumigatus and propose future perspectives on exploiting this pathway for designing new fungal-specific therapeutics. Enhanced hole transport in InGaN/GaN multiple quantum well light-emitting diodes with a p-type doped quantum barrier. Effect of ascorbic acid and alpha-tocopherol supplementations on serum leptin, tumor necrosis factor alpha, and serum amyloid A levels in individuals with type 2 diabetes mellitus.

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The number of patients identified and admitted with Moyamoya disease has risen dramatically in the last decade. Environmental challenges might affect the maternal organism and indirectly affect the later ontogeny of the progeny. We show how the long range correlations generate statistical features in these properties, which are best exhibited when considering different length scales. Advantages include better detection of behavioral health and trauma-related issues, early indicators of case progress or risk of failure, and program- and system-level learning. Clinicians managing South Asian patients with RA need to be aware that low adherence may be linked to negative requip xl cost beliefs about medicines and illness representations of RA. Synthesis of 4-substituted phenyl 2,5-anhydro-1,6-dithio-alpha-D-gluco- and -alpha-L-guloseptanosides possessing antithrombotic activity. In vitro characterization of the oxidative cleavage of the octyl side chain of olanexidine, a novel antimicrobial agent, in dog liver microsomes. No other author has a financial or proprietary interest in any material or method mentioned. Epigenetic inactivation of 14-3-3 sigma in oral carcinoma: association with p16(INK4a) silencing and human papillomavirus negativity. Retinopathy of prematurity: screening, incidence and risk factor analysis.

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