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Biclar (Clarithromycin)
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Biclar

Biclar is used in the treatment of infections caused by bacteria. The infections may include pneumonia, respiratory tract infections, lyme disease, strep throat, skin infections, H. pylori infection, among others. It is categorised as an broad-spectrum antibiotic which protects against mycoplasma, chlamydia and mycobacteria and other gram-negative and gram-positive bacteria. It works by decreasing protein production of these bacteria. It is available in the form of tablets, pills and liquids.

Other names for this medication:
Abbotic, Biotclarcin, Bremon, Ciclinil, Clabact, Clabel, Clacina, Clarimax, Clarimycin, Claritt, Clarix, Clarocin, Clarogen, Claron, Clarosip, Clarytas, Clasine, Claxid, Cleanomisin, Clormicin, Eliben, Euromicina, Finasept, Hecobac, Helozym, Italclar, Kailasa, Kalecin, Karin, Klabet, Klarigen, Krobicin, Lekoklar, Lyoclar, Maclar, Macromicina, Monozeclar, Quedox, Rolicytin, Synclar, Xylar, Zeclaren

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Also known as: Clarithromycin

Description

Clarithromycin is used to treat bacterial infections in many different parts of the body. It is also used in combination with other medicines to treat duodenal ulcers caused by H. pylori. This medicine is also used to prevent and treat Mycobacterium avium complex (MAC) infection.

Clarithromycin belongs to the class of medicines, known as macrolide antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Dosage

The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days (up to the adult dose). Refer to dosage regimens for mycobacterial infections in pediatric patients for additional dosage information.

For the treatment of disseminated infection due to Mycobacterium avium complex (MAC), Biclar Filmtab and Biclar Granules are recommended as the primary agents. Biclar Filmtab and Biclar Granules should be used in combination with other antimycobacterial drugs (e.g. ethambutol) that have shown in vitro activity against MAC or clinical benefit in MAC treatment.

For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of Biclar is 500 mg every 12 hours.

For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours up to 500 mg every 12 hours.

Biclar therapy should continue if clinical response is observed. Biclar can be discontinued when the patient is considered at low risk of disseminated infection.

Overdose

Overdose symptoms may include severe stomach pain, nausea, vomiting, or diarrhea.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not refrigerate or freeze the oral liquid. Throw away any unused mixed medicine after 14 days.

Detailed Biclar dosage information

Side effects

The most common side effects associated with Biclar are:

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Contraindications

Discontinue immediately if hepatitis or severe hypersensitivity reactions occurs. Severe renal impairment. Proarrhythmic conditions (eg, hypokalemia, hypomagnesemia, bradycardia); avoid. Myasthenia gravis. History of porphyria; avoid concomitant ranitidine bismuth citrate. Elderly. Pregnancy (Cat.C): usually not recommended. Nursing mothers.

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In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex. Feasibility of endoscopic mucosal resection as salvage treatment for patients with local failure after definitive chemoradiotherapy for stage IB, II, and III esophageal squamous cell cancer. A preliminary mode-coupling theory (MCT) analysis of the light-scattering and neutron-scattering data indicates that T(C) greater, similar150 K, at least 25 K above T(G). The induction of apoptosis offers an appropriate method for cancer treatment. This paper demonstrates that alpha-ManNAc is the first formed anomer and therefore the reaction proceeds with a net retention of configuration at C-1. The cellular function of some of these genes is beginning to be elucidated. The presence of FcgammaRIII on human macrophages makes it possible that the IgG, FcgammaRIII, macrophage, and PAF pathway also contributes to human anaphylaxis. The plataspid stinkbug Megacopta cribraria, known as kudzu bug, recently invaded North America and now has become not only an agricultural pest of soybean but also a nuisance pest. Necrotizing external otitis in an infant receiving cytostatic therapy for neuroblastema has been described. This study demonstrates for the first time that in vivo chronic interruption of the endogenous oxidative stress cascade reduces HC-induced NF-kappa B activation and normalizes NO bioactivity in association with preservation of coronary endothelial function.

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Influence of a dense plasma on the fine-structure levels of a hydrogenic ion. This cluster represents the largest assembly of contiguous nif-fix and associated genes so far characterized in any diazotrophic bacterial species. We report the following 2 cases of breast tumor metastasis to the uterine cervix with different presentations: case 1 is an isolated cervix metastasis and case 2 is a disseminated metastatic disease with cervix involvement. The characterization is done to determine the optimal recording conditions. After many years of therapy limited to 5-fluorouracil (5-FU)-based chemotherapy, a number of new discoveries have significantly advanced this field in the last decade. Structural specificity for the photoinactivation of nucleic acids by furocoumarins. The TRUGENE assay produced sequence data for 31 isolates but not for one C and two G isolates. We present a case of a manual laborer who sustained a multifaceted injury from a metal press machine with loss of composite structures including the middle and ring finger metacarpophalangeal joints, flexor and extensor tendons, digital nerves, and dorsal/volar soft tissues.

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Here, sperm from mice with mutations in the neuronal GlyR alpha or beta subunits (spasmodic and spastic) were shown to be deficient in their ability to undergo the AR initiated in vitro by glycine or by solubilized ZP from mouse eggs. Influence of binder droplet dimension on granulation rate during fluidized bed granulation. The affect of these genes on enzyme activity is codominant and additive. Among the molecular parameters, TP53 mutations and LOH10q emerged as favorable and poor prognostic factors, respectively. Integration of health care process analysis in the design of a clinical information system: applying to the blood transfusion process. Models and the early detection of disease: methodological considerations. Rapid extraction of lexical tone phonology in Chinese characters: a visual mismatch negativity study. In fact, there were trends to a positive correlation between leptinemia and body protein stores, as estimated from the scrutinized markers.

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Acute renal vein thrombus and renal atrophy following shock wave lithotripsy: a unique complication. One hundred urine specimens were tested, and 23 were found to contain inhibitors of the PCR, if not subjected to DNA extraction prior to amplification. Arsenic concentrations in rice plant parts except husk were not affected by application of phosphate. In this study, we used morphological studies to show that the development of non-capillary vessels occurs at other corpus luteum stages. This study was conducted on 193 students of both 1st and 2nd year MBBS. To assess whether an association exists between systemic use of anti-inflammatory medications at baseline and the prevalence or incidence of either late or early age-related maculopathy (ARM) in a population-based cohort. Extending the table of stages of normal development of the axolotl: limb development. Use of Escherichia coli operon-fusion strains for the study of glycerol 3-phosphate transport activity. They also suggest that caution should be observed when using subcellular reporter fusions to determine the topological organization of Tat-dependent membrane protein complexes.

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This paper highlights the effect of PR on exercise tolerance and breathlessness in patients with chronic lung disease. However, the clinical value of serum HER2-extracellular domain (ECD) in gastric cancer has not yet been defined. A single supervised rinse was taken and subsequent 2x daily rinses over the following 3 days. Our results suggest that NTD risk declines markedly with modest increases of total folate in early pregnancy. The temporalis and masseter muscles have a complex architectural design with large attachment areas. Optical biometric measurements of diabetic and nondiabetic patients (between the ages of 25 and 85 years) who applied to the ophthalmology clinic were noted from March to June 2013. Hemorrhage caused by angio-perforating ulcer enclosed within the pancreas. The 3D measuring accuracy of both low-cost sensors was estimated based on the deviations of test specimens. Cytokines, as well as many other factors, play an important role in pituitary physiology, affecting not only cell proliferation but also hormone secretion.

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Finally, we performed a codon-based evolutionary analysis indicating a general high level of purifying selection in the three Cucurbitaceae MLO gene families, and the occurrence of regions under diversifying selection in candidate susceptibility factors. The diamine oxidase catalyzed metabolism of 14C-putrescine was studied in the ovaries of immature rats with and without stimulation by gonadotrophin. Abdominal aneurysmectomy in a patient with an abdominal aortic aneurysm who has cardiac, renal, or pulmonary disease is associated with a high surgical mortality. Yeast-like flora of the male and female urogenital system with regard to enzymatic activity and clinical symptoms. The diageotropica (dgt) mutation has been proposed to affect either auxin perception or responsiveness in tomato plants. Consistent with other studies of homeless youth, data revealed high rates of substance use and high rates of substance dependence. Timing of contrast arrival in the left heart chambers is key to differentiating intra-cardiac shunting from extra-cardiac pulmonary transit. The expression and localization of uMtCK and hexokinase II, a marker of glycolysis, were examined in prostate carcinoma cell lines using western blot and immunofluorescence. Disseminated intravascular coagulation (DIC) can frequently be observed in patients with severe inflammatory response. The porosity of the three-dimensional structure can be controlled by varying the amount of radical initiator, thereby allowing the design of porous scaffolds tailored towards specific potential applications.

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Six consecutive patients with oesophageal carcinoma were treated by external beam irradiation (60 Gy in 30 fractions over 6 weeks) followed by hypofractionated intracavitary HDR brachytherapy (10 Gy in 2 fractions). These results demonstrate that human Lf can mediate both antimicrobial and immunomodulatory activities with downstream effects on the outcome of immune pathology in infectious and inflammatory disease. Furthermore, the expression of green fluorescent protein-Rac1 or -Cdc42 chimeric proteins in ECs results in the targeting of these fusion proteins to intracellular vacuole membranes during lumen formation. To analyze treatment outcome and the accuracy of positive sputum smear at 2 months to predict treatment failure in a cohort of patients with tuberculosis (TB) in a rural setting in Angola. Nursing in the framework of long-term care insurance as a basic principle of a specific nursing approach of rehabilitation?. Erythropoietin or VEGF stimulated hRMVEC proliferation and STAT3 activation. It is absolutely necessary for the patient to lie down for 25 to 30 minutes to reach these goals. An ideal composition of biomechanical properties and biocompatibility has not been achieved so far. Longitudinal roentgencephalometric study on growth of the facial cranium and mandible in Japanese children. Health outcomes such as survival, minimal disability and well-being are presumptively dependent on food and ecosystems.

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The response of microvessles to the endothelium-dependent dilator adenosine diphosphate (ADP) 10(-9)-10(-4) M, the endothelium-independent dilator nitroprusside 10(-9)-10(-4) M, and ET-1 10(-13)-10(-8) M was measured by videomicroscopy in the presence of 0-2 minimum alveolar concentration (MAC) of isoflurane. To assess epidemiologic characteristics, clinical and pathologic patterns of presentation, and treatment strategies in a contemporary population with renal masses (RMs). Activation of the Ah receptor (AhR) by halogenated aromatic hydrocarbons (HAHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), can produce a wide variety of toxic and biological effects. This study was performed to determine the effect of a dental chew on dental hygiene and gingival health in cats. Six days after surgery, the cat was eating and drinking normally, with the tube only used for administration of medications. Dechlorination of lindane, dieldrin, tetrachloroethane, trichloroethene, and PVC in subcritical water. We therefore entered 51 hemophiliacs with factor VIII inhibitors into a double-blind randomized crossover study to compare two commercial prothrombin-complex concentrates (Konyne and Proplex) and an albumin placebo. In this study, the effect of delayed RC was assessed in a nationwide cohort. Oral adenoid/acantholytic squamous cell carcinoma: a report of two cases rocaltrol drug with review of literature. Taiwanese children with HCG-secreting GCTs often have clinical manifestations related to endocrine dysfunction.

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Newer approaches to the isolation, identification, and quantitation of steroids in biological materials. Despite high mortality and morbidity rates, surgery remains the only chance for cure in most octogenarians with pancreatic disease. Geochemical variability of heavy metals in soil after land use conversions in Northeast China and its environmental applications. To address the relationship between BRCA1 carriership and colorectal tumorigenesis, we studied the genetics of a breast-ovarian cancer family with 7 cases of colorectal cancer. Mucosa-associated lyphoid tissue hepatic lymphoma with low-grade malignancy associated with primary biliary cirrhosis. In contrast, both strains induced IL-8 promoter activity in TLR2-transfected HeLa cells.

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