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Bestradiol (Estradiol)

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Bestradiol has several functions in the female body. Its main function is to mature and then maintain the reproductive system. During the menstrual cycle, increased Bestradiol levels cause the maturation and release of the egg, as well as the thickening of the uterus lining to allow a fertilized egg to implant.

Other names for this medication:
Bestradiol, Conjugase, Divigel, Edval, Espauz, Estogen, Estraderm, Estradiol, Estrofem, Evafem, Evalon, Evaride, Menocare, Mixogen, Oestrogel, Premarin, Progynon, Progynova, Sandrena

Similar Products:
Diovan, Lexapro, Fosamax, Maxolon, Persantine, Lopressor, Lasix, Cordarone, Viramune

Also known as: Estradiol


Estradiol vaginal gel, insert, and ring are used to treat changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by low estrogen levels or menopause.

Estradiol vaginal gel and ring are also used to treat moderate to severe hot flashes and other symptoms of menopause or low amounts of estrogen. The hormone from the vaginal gel or ring is absorbed through your vagina. It works by preventing symptoms, such as feelings of warmth in the face, neck, and chest, or sudden strong feelings of heat and sweating (hot flashes) in women during menopause.

Estradiol vaginal insert is also used to treat moderate to severe painful sexual intercourse caused by menopause.

This medicine is available only with your doctor's prescription.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to help lower this risk. Call your doctor at once if you have any unusual vaginal bleeding.

Wash your hands before and after inserting Bestradiol Vaginal.

Use the applicator provided to measure the prescribed dose of estradiol vaginal cream. Take apart the cream applicator and wash it with mild soap and warm water after each use.

Each Bestradiol Vaginal tablet is supplied in a single-use disposable applicator. Throw the tablet applicator away after one use.

You should not be able to feel the vaginal ring once it is in place. Leave the vaginal ring in place for 90 days, then remove it. Your doctor may want you to replace it with a new ring. The ring does not need to be removed during sexual intercourse. If the ring is bothersome, you may remove it, rinse it with warm water, and reinsert it after intercourse.

To remove the ring, loop a finger through the ring and gently pull it from the vagina. Call your doctor if you have trouble removing a vaginal ring.

Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis and have a mammogram every year while using estradiol.

If you need major surgery or will be on long-term bed rest, you may need to stop using Bestradiol Vaginal for a short time. Any doctor or surgeon who treats you should know that you are using estradiol.

Store at room temperature away from moisture and heat. Keep the vaginal ring in its protective pouch until you are ready to use it.

Detailed Bestradiol Vaginal Cream dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Bestradiol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using estradiol.

Avoid using other vaginal products without your doctor's advice.

Grapefruit may interact with estradiol and lead to unwanted side effects. Avoid the use of grapefruit products.

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Hemophilic pseudotumor of the ulna treated with low dose radiation therapy: a case report. Thus, as shown in these studies, p68 is expressed in early neural development and in various mesodermal tissues in a variety of chordate embryos, including chick, frog, and ascidian. Although certain changes in the brain may reflect fear learning, there are no known markers that indicate whether an aversive experience will develop into fear memory. These findings indicate that alpha-smooth muscle actin containing fibroblastic cells are a regular part of the intact as well as the remodeled anterior cruciate ligament. Minute anisotropic granules (storage substances) in two smaller clusters were found also in diatoms of the genus Navicula, whereas the green alga of the genus Mougeotia was revealed to contain, in addition to minute anisotropic granules (storage substances) occurring in low numbers in the cytoplasm, also a strongly birefringent cell wall (shape birefringence).

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To reduce the extent of lymphnode excision, the sentinel node biopsy has been used as an accurate technique to assess the status of the lymphnodes in the regional drainage basin in solid tumors, and more recently, in thyroid carcinoma. Isolated bradycardia due to skull pin fixation: raised ICP or TCR?. Here, we show that the transcription factor GAGA can stimulate transcription by linking an enhancer to its cognate promoter. Numerical simulations are carried out to demonstrate the efficiency of the proposed control strategy. The general prevalence of pain is similar to that reported by other.

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We examined effects of local KA (3-300 micromol/l for 10 min) treatment on cortical COX-2 expression in anesthetized piglets using a closed cranial window. Chooramani technique: A novel method of omental transposition in traumatic spinal cord injury. Moreover, the perinatal injection of 192 IgG-saporin may interact with the brain plastic capacity to react to other injuries. The goal of this work is to examine general concepts derived from the bacterial XylE, GlcP, and other MFS transporters for their relevance to the GLUTs by comparing conservation of functionally critical residues. Between 2010 and 2011, 98 patients underwent anterior cruciate ligament reconstruction with an allograft. Better immunosuppressive agents are needed to improve long-term results. Previously we demonstrated that pulse pressure is a strong risk factor for coronary events in male hypertensive subjects in the MRC Mild Hypertension Trial, whereas stroke is best predicted by mean blood pressure.

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The possibility is raised that the decrease in cellular packing density in the 5-HT nuclei may reflect the appearance of the non-5-HT components of the raphe nuclei. The external lateral parabrachial subnucleus projected to the lateral parafascicular, reuniens, central medial, parvicellular part of the ventral posterior, and caudal ventromedial thalamic nuclei. Inter-rater reliability between 2 neuroradiologists was evaluated in 20 patients, 10 with known ARIA-E and 10 without, by using the intraclass correlation coefficient. The requirement for TLR cooperation is supported by the finding that TLR2 needs a partner to activate tumor necrosis factor-alpha production in macrophages. This study compared the degree of mucosal inflammation in human immunodeficiency virus type 1 (HIV-1)-infected gut mucosa with that in tissue samples from subjects with inflammatory bowel disease (IBD) and from healthy seronegative control subjects. After 48 months post-treatment, there is no clinical evidence of recurrence. In terms of exposure quantification, we used ambient air pollution exposures as a proxy for personal exposures, potentially leading to exposure misclassification. Lipid metabolism in the development of cholesterol gallstones in hamsters.

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Urinary excretion of biotin in children with and without pathological skin conditions, with special reference to the relations of seborrhoeic dermatitis and eczema. This study investigated the applicability of transport distraction osteogenesis with an internal appliance for reconstruction of the temporomandibular joint (TMJ). Ammonia volatilization from a Chinese cabbage field under different nitrogen treatments in the Taihu Lake Basin, China. Perinuclear staining of CNTF-IR was seen in mouse sciatic nerve but only weakly in IFP. The problem of unreasonably high pharmaceutical fees for patients in Chinese hospitals: a system dynamics simulation model. Treatment with antibiotics and evacuation of pleural fluid caused short-lasting improvement. A 6-mm slicing protocol is significantly less sensitive than a 3-mm protocol for the detection and quantification of coronary artery calcium. Also, dental hygienists working in states not currently allowing this service, should consider these results when proposing change to their state practice acts.

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We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Several allyl reagents, commonly used in radical allylation reactions, were evaluated, and some of these reagents resulted in allylation when used in the DiazAll reaction. In multivariate analysis, high donor age, immunized female donor to male recipient, and grades II-IV acute GVHD were significantly associated with a longer time to clinical tolerance. Ventricular catheter placement in children with hydrocephalus and small ventricles: the use of a frameless neuronavigation system. However, Bmps were not detected in the root sheath epithelium, and Msx transcripts were absent from the underlying mesenchyme. Based primarily on experience with latanoprost, the association between ocular hypotensive lipids and cystoid macular edema, even in high-risk eyes, although present, appears to be low.

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A less invasive management strategy in case of a history without intracranial haemorrhage seems justified based on results in our population. The lowest half-lives corresponded to densities of bacteria that stimulate response of bacterivores. The linear stability analysis of the problem shows that a nonuniform, azimuthal magnetic field, applied tangential to the cell, tends to stabilize the interface. Tracheoplasty using costal cartilage grafts to enlarge the lumen was successfully employed in such a case, and the technique is described. Immunoelectron microscopy showed K(ir)6.2 antibodies specifically label perimeter membrane regions of the secretory granule. The vertical component of oblique saccades was also influenced, albeit to a much lesser extent: the duration of the vertical component typically increased, while the vertical peak velocity either decreased or exhibited no significant change. Injection into normal vitreous results in long-term staining of the visual pathway. In a subsequent study, the developed implementation strategy will be assessed on its effectiveness, feasibility and costs.

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Physical examination starts with standard gynecological examination. There are limited data about the correlation between brain natriuretic peptide (BNP) levels and arrhythmic risk assessment in patients who receive device therapy for the treatment of heart failure (HF) or for the prevention of sudden cardiac death. The black lacrimal sac: a clinicopathological correlation of a malignant melanoma with anterior lacrimal crest infiltration. Both glutamate and bicuculline methiodide enter the brain in immature rats but the mechanisms are probably different - glutamate is transported actively through the blood-brain barrier whereas no similar system is known for bicuculline methiodide. Some aspects of the chemical composition of translucent dentine.

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Cranio-maxillary (mandibular) internal skeletal wiring with steel ligatures in jaw fractures. Of all mandated PMSTs, only one in 8,461 was positive for infectious syphilis. During the night-time, the intragastric pH with famotidine was quite similar to that with lansoprazole in the heterozygous extensive metabolizer and poor metabolizer groups. Baseline and follow up measures of program reach, risk factors, and injury rates in both communities were used to evaluate program process, impact, and outcome. To compare CTPA with pulmonary angiography as a second-line investigation in patients with a ventilation/perfusion (VQ) scan indicating an intermediate probability of PE. The patient was a 35-year-old man with a 20-year history of nasal obstruction. Willing and able: a closer look at pain Willingness and Activity Engagement on the Chronic Pain Acceptance Questionnaire (CPAQ-8). With the present method, such adducts were detected as the base forms from DNA chains using depurination in the pretreatment process. Compared to mice, the pig model has plentiful types of teeth, which is similar with the human dental pattern. However, recent data indicate that this enzyme may not be specific for senescence in all tissues and probably represents the expression of endogenous lysosomal acid beta-galactosidase, which is expressed by a variety of differentiated cell types.

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A review of the relevant literature describing the use and the performance of ventriculocholecystic shunts in comparison with other ventricular shunts is considered. Effects of sodium fluoride on reproductive function in female rats. Unfixed as well as glutaraldehyde-fixed pelleted cells from pure cultures of Streptococcus mutans subspecies sobrinus (B13) were embedded in glycolmethacrylate. We first image nanoscale clusters of maghemite particles through both spin resonance spectroscopy and spin relaxometry, under ambient conditions. Accepted international criteria and standardised otological and, when necessary, psychiatric assessment were applied to establish each diagnosis. We attempted to identify the functional importance of intracellular domains of the cholecystokinin (CCK) receptor by their over-expression in receptor-bearing Chinese hamster ovary (CHO-CCKR) cell lines. Fractionation on Sephadex G-50 resulted in one definite peak of protein and in three sugar peaks. Mathematical approach to the differential diagnosis of phenotypically similar hereditary diseases. Although testing and treatment for Staphylococcus aureus colonization before total joint arthroplasty (TJA) are well described and understood, the durability of decolonization has not been studied extensively. HIV-1/AIDS-associated neurologic disorders declined in parallel.

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Leaf water relations of Eucalyptus cloeziana and Eucalyptus argophloia in response to water deficit. Of 1426 respondents, 679 and 747 answered survey 1 and 2, respectively. Growth and differentiation factors (GDF) 5, 6, and 7 are known to play roles in tendon and ligament formation, and are therefore probably involved in the formation of periodontal ligament. The structure of the O antigen has been determined, but the roles of specific genes in synthesizing this structure are relatively unclear. We provide a systematic study of the sources of variability in expression profiling data using 56 RNAs isolated from human muscle biopsies (34 Affymetrix MuscleChip arrays), and 36 murine cell culture and tissue RNAs (42 Affymetrix U74Av2 arrays). Combined thoracic duct fistula and immunosuppressive chemotherapy. Although its chemical profile and pharmacological activities have been studied extensively during the last two decades, limited attempts have been made to decipher the biosynthetic route and identification of key regulatory genes involved in withanolide biosynthesis. The link from form to process is made through conceptualizing form-process relationships for riffle-pool couplets into geomorphic covariance structures (GCSs) that are then quantitatively embedded in a synthetic channel model. Present knowledge on the etiology, clinical features, epidemiology, pathogenesis, diagnosis, and management of CSD are presented.

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Stryphnodendron adstringens extract associated with the hooves trimming surgical procedure singulair 10 mg tablet picture for the treatment of bovine digital dermatitis. The fistula drained into the neighboring paravertebral veins and refluxed into the intradural venous systems. Analysis of variation in the human beta-globin gene cluster using a novel DHPLC technique. Chemical analyses confirmed the loss of N-acetylgalactosamine (GalNAc) and the presence of NeuNAc in the cgt mutant. Decreased globin messenger RNA activity associated with polyribosomes in thalassaemia. Addition of Si to the shoot induction medium significantly increased SOD, POD, APX, and CAT activity in regenerated shoot buds as compared with the control. XPar-1A and XPar-1B are expressed both maternally and zygotically in an indistinguishable pattern. Novel Aortic Reconstruction Strategies: Endovascular Aneurysm Repair. Naturally occurring IgM antibodies to a small RNA insect virus in some mammalian sera in New Zealand. When an unexplained INR value exists, a stressor should be evaluated as a potential cause.

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These internal and external changes of chondrogenic differentiation were then observed over 3 weeks later in culture, as confirmed through fluorescent immunocytochemical staining and real-time quantitative reverse transcriptase polymerase chain reaction. MAIT cells from patients with active TB exhibited impaired cytokine and cytotoxic response to M. To report a case of complete occlusion of the capsulorhexis opening in a DM patient with high hemoglobin A1C level. Accurate staging of patients preoperatively and selected multidisciplinary approaches to individual patients may eventually lead to improvements in survival for patients with gastric cancer. To detect potentially small but significant differences, we performed an analysis in a highly homogeneous group. The dual role of CHAPS in the crystallization of stromelysin-3 catalytic domain. The present work shows that the action of VM (a 500-dalton modified depsipeptide) in vivo and in vitro persists upon its removal. coli K 12 802 were transformed with the plasmid DNA of the wild strain to the hemolytic strain of S. Steroid 5-alpha reductase type II V89L substitution is not associated with risk of prostate cancer in a multiethnic population study. Medical Corps of the French Navy in the port of Toulon during 19th century.

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Novel flow injection methods for drug-receptor interaction studies, based on probing cell metabolism. Early diagnosis and treatment are very important because the raised intraorbital pressure may irreversibly damage the optic nerve. None of the paired trials reported an appropriate paired analysis. Clinical signs more indicative of colitis than anal furunculosis (increased frequency of defecation, mucus in faeces and diarrhoea) were not observed more frequently in dogs with confirmed colitis compared with those with furunculosis alone. In this review, we focus on cytokines which have substantial pathogenic significance and also highlight the possible clinical applications of these cytokines. A randomized comparative multicentre study between ECP as single therapy and ECP plus immunosuppressants and conventional therapies is required to firmly establish photopheresis as a possible basic treatment to combine with conventional therapies for EF. Short-term results indicated that participants with initially elevated depressions scores (high risk) who received the intervention showed a significantly greater decrease in depressive symptoms and increase in life problem-solving scores from pre- to postintervention compared with a high-risk control group. RATIONALE AND OBJECTS: We describe a new web-based physics course for radiology residents preparing for the Exam of the Future (EOF). The frequency of a severe postphlebitic syndrome after our surgical approach is lower than the rates published for anticoagulation treatment alone.

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Compensatory enlargement of the plantaris muscle was induced in one leg of each rat by surgical removal of the ipsilateral soleus and gastrocnemius muscles. The full multistep process was important in getting participation agreement. We conclude that beta1 integrin-FN interactions enhance normal primitive progenitor preservation with or without cell division, and that these mechanisms are impaired in CML primitive progenitors. Economic aspects of the activities of recovery departments and departments of rehabilitative treatment. Occurrence of Salmonellae in retail raw chicken products in Ethiopia. Methods of quantitative evaluation of the structure of cytological objects based on the data of scanning microphotometry are described: calculation of histograms (weighed, average, reduced) and coefficients of relief and texture. To describe trajectories of functional decline over 84 months and study associated risk factors among adults initially without limitation who had or were at risk of knee OA. The surface roughness of a dental implant affects the epithelial wound healing process and may significantly enhance implant prognosis.

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Case selection, surgical technique, and clinical and oncologic results were reviewed. Mechanism of the selective surge of follicle-stimulating hormone in dioestrous rats during the induction of ovulation by human chorionic gonadotrophin. Effect of depression-related somatic pain on treatment satisfaction and daily living functions. For this reason, in procedures combining femoral osteotomy with, for instance, triple pelvic osteotomy the use of CAPOS instrumentation is still preferred. The tissue distribution and intensity of protein expression of carboxylesterase-2 have not been defined in any organ or tissue. All mammalian cells absolutely require polyamines (putrescine, spermidine, and spermine) for growth. The as prepared AgNPs were characterized using UV-vis spectroscopy, transmission electron microscopy (TEM), particle size analyzer, polydispersity index (PdI), zeta potential. The results of targeted levels of platelet inhibition cannot be extrapolated between different clinical trials of GP IIb-IIIa antagonists unless the same assay is used. Animals (female Swiss mice, 25 g) were treated with the EO and, 30 or 60 min after intraperitoneal (i.p.) or oral (p.o.) administration, respectively, injected with pentylenetetrazole (80 mg/kg, i.p.) and observed for 30 min.

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We assessed the prevalence and correlates of acute post-traumatic stress disorder (PTSD) and depression among residents of Manhattan five to eight weeks after the attacks. The concentrations of prolactin in plasma were measured before and after the injection of TRH in pregnant ewes and in non-pregnant ewes during the breeding season and seasonal anoestrus. Lower concentrations resulted in malformed water vascular systems in several replicates. The purpose of this qualitative study was to explore the experiences of students and teachers about student-teacher relationship in the context of clinical nursing education in Iran. Herein, we investigate the effects of TWEAK on vascular injury and adhesion molecule expression in CV mice. And the resistant rates of integron positive and negative strains were tested by drug susceptibility. To determine by CT the thickness of the stomach wall or the penetration of tumor lesions, the presence of enlarged lymph nodes and possible metastases. Long-range polymerase chain reaction for specific full-length amplification of the human keratin 14 gene and novel keratin 14 mutations in epidermolysis bullosa simplex patients. Nephrologists need to deal with the problem of vascular access management in the same manner as the other major problems that affect our dialysis patients. Antigen stability to fixation and heat were first assessed by quantitating the resultant effect on binding how often can you take zyrtec allergy medicine of the monoclonal antibodies to a macrophage cell line in vitro, using a radiolabeled second antibody.

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Since many cancer cells have shown resistance to ceramides, curcumin is now being used in combination with ceramides because of its ability to reverse multidrug resistance. The level of serum carcinoembryonic antigen was still within the normal range. Virus-induced signaling adaptor (VISA) functions as a critical adaptor in the regulation of both the production of type I IFNs and the subsequent control of the innate antiviral response. Glioblastoma multiforme is the most common adult malignant brain tumor but is notably less common in children. It is hypothesized that lack of ability to redistribute muscle activation pattern in can i take second dose of diflucan early the shoulder region or the upper extremity increases the risk of development of work related symptoms. The modified Blalock-Taussig shunt: a 6-year experience from a developing country.

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Health care workers are exposed to a wide variety of hazards, including biological, chemical, physical and psychological stressors. Concentrations of clindamycin hydrochloride in homogenates of normal dog skin when administered at two oral dosage regimens. Fluctuating thermal conditions may generate variable patterns of selection on reaction norms for growth rate in the field. Lipoic acid content of dihydrolipoyl tenormin generic drug name transacylases determined by isotope dilution analysis. One conceivable mechanism is the activation of pulmonary macrophages. Study results suggest that effective interventions to reduce the prevalence of STEC O157 contaminated carcasses should initially be based on improved abattoir hygiene.

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Relative contribution of c1q and apoptotic cell-surface calreticulin to macrophage phagocytosis. Bladder dysfunction after parturition in a rat model caused by AUR may be restored to the non-AUR structural and functional level after SNS treatment. We report a family with 6 members affected by a long-lasting paroxysmal exertion-induced dyskinesia. A characteristic sequence of HRCT changes is seen in most patients receiving this type of radiotherapy.Ooi, G. To evaluate use and level of comfort in using ASDs for oral cancer screening among dental hygienists.

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To explore how nurses perceive the experiences of long-stay surgical intensive care unit patients and their families in order to gain insights on how nurses could cultivate family resilience. Homework assignments can enhance therapeutic impact and increase therapy effectiveness by encouraging patients to focus on therapy-related issues between sessions. Warty linear streaks of the palm and sole: possible late manifestations of incontinentia pigmenti. Overall, this work is the first demonstration of the feasibility of virus-based delivery of the SMN-coding gene to restore the normal SMN expression pattern in SMA patient-derived cells, and holds promise for gene therapy of SMA, as a potential long-term therapy for this devastating childhood disease. Our report gives further insight into the hormonal mechanisms underlying the effects of surgically altered anatomy of different parts of the small intestine on glucose homeostasis that is highly important, since it may facilitate novel conservative therapies of diabetes without the need for surgery. A novel Ala275Val mutation in factor X gene influences its structural compatibility and impairs intracellular trafficking and coagulant activity. Preliminary report of a clinical trial of oral norethynodrel for fertility control. The influence of the artefact may be reduced by inserting ultrasound probes with small footprint into the resection cavity for a close-up view of the areas with suspected tumor remnants. The procedure cleared the lesion completely and preserved the physiological function of the external auditory canal. Changes in Thirst Intensity During Optimization of Heart Failure Medical Therapy by Nurses at the Outpatient Clinic.

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