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Benclamet (Glibenclamide)
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Benclamet

Benclamet is an inexpensive drug that helps to treat type 2 diabetes. It is slightly less popular than comparable drugs. Benclamet is only available as a generic drug; all brands have been discontinued. Benclamet is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.

Other names for this medication:
Aviglen, Benclamet, Benformin, Betanase, Betrol, Codica, Combidos, Comdiab, Diabetnil, Diolin, Eumet, Glifil, Glinil, Glitrac, Glucosafe, Glucosil, Glutowin, Glyboral, Glycurb, Glycurub, Melitus, Metclam, Metica, Pionorm, Sugatrol, Sugnil, Sugronil, Triglucored

Similar Products:
Valium, Arava, Prograf, Micardis, Danocrine, Loxitane, Suprax

Also known as: Glibenclamide

Description

{name} is an oral diabetes medicine that helps control blood sugar levels.

{name} is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

{name} is not for treating type 1 diabetes.

Dosage

Usual Adult Dose for Diabetes Type 2:

Standard Benclamet: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized Benclamet: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard Benclamet, micronized Benclamet, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting Benclamet at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Benclamet dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Benclamet overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Benclamet are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Benclamet, micronized, the following should be considered:

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Human immunodeficiency virus type 1 infection and replication in normal human oral keratinocytes. Hepatocyte growth factor (HGF), a ligand of c-Met receptor, stimulates activation of cellular kinases via phosphatidylinositol 3-kinase (PI3-kinase). The separate explanatory models for physical and verbal aggression indicate that these may be unique entities with different foci for treatment. Lamivudine is an oral nucleoside analog that is better tolerated than interferon. Impact of the front-of-pack labels was also evaluated across sociodemographic subgroups based on age, educational level, income, and nutrition knowledge. The nucleoside reverse transcriptase inhibitors inhibit mitochondrial DNA synthesis and may thus exacerbate existing viral-induced nerve damage.

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Designer Ge/Si composite quantum dots with enhanced thermoelectric properties. An anterior chamber maintainer was placed in patients with glaucoma to maintain stable intraocular pressure and minimize the risk of intraocular hemorrhage due to sudden pressure changes during surgery, when an Ahmed valve is implanted. Insulin stimulation of glucose and amino acid transport in mouse fibroblasts with elevated membrane microviscosity. To prospectively analyze gender differences in the presentation and response to cabergoline treatment in 219 consecutive newly diagnosed patients with hyperprolactinemia. A novel gene was obtained and was mapped by homologous analysis against human genome sequence. Each patient had a complete ophthalmic evaluation, including relevant history, visual acuity testing, slit-lamp examination, applanation tonometry, gonioscopy with a Posner lens and standard automated perimetry. Risk of gastric cancer among smokers infected with Helicobacter pylori. Performance of AdMSPCA and adaptive PCA on a real WWT data set compared and contrasted. Ocular surface and anterior segment abnormalities must be considered when examining patients with Brachmann-de Lange syndrome. In 52 cerebral malaria (CM), 21 multi-organ-dysfunction (MOD), 12 non cerebral severe malaria (NCSM) and 43 uncomplicated malaria patients, the MP level was found to be significantly elevated in febrile malaria patients compared to healthy controls and a striking decrease in MP level was observed with the clearance of the P.

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In the later phase therapeutic procedure for fluid necrotic collections is US/CT percutaneous catheter drainage. Outflux of various phosphates during membrane depolarization of excitable tissues. Using confocal laser scanning microscopy, we co-localized TNF with each MMP, and observed spatial and temporal distinction in their distribution. Serological evidence of type 2 (North American genotype) porcine reproductive and respiratory syndrome virus in Nepal. IL-15 stimulates NK cells to secrete CC-chemokines, such as, macrophage inflammatory protein-1alpha (MIP-1alpha), macrophage chemotactic protein-1alpha (MCP-1alpha) and regulated upon activation, normal T cells expressed and secreted (RANTES) in both HIV-infected individuals and controls with no significant difference. To account for time dependency of the gene expression measurements over time and the noisy nature of the microarray data, the mixed-effects model using B-splines was introduced. Obstructed defecation has been reported in patients after pelvic pouch reconstruction. The Nottingham Health Profile was used to assess health status, and the Knee Society score was used to assess clinical outcome. Evaluation of procedure designed to enhance coronary collateral blood flow.

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Maternal control of sex ratio in Rana rugosa: evidence from DNA sexing. The purpose of this study was to examine the effects of N-acetylcysteine (NAC), a nucleophilic agent, and two nonnucleophilic N-acetylamino acids, N-acetylserine (NAS) and N-acetylalanine (NAA), on NDPS and NDPS metabolite-induced nephrotoxicity. We wanted to establish whether the expression of the protein product of these genes was altered in lymphocytes treated with extracorporeal photopheresis (ECP) prior to re-infusion and therefore possibly implicated in the early apoptosis observed. In a fraction of the time required by conventional methods, microwave-accelerated one-pot hydrostannylation/Stille coupling allows 1-alkynes to be efficiently transformed into 1,3-dienes or styrenes. Menarche was delayed by about 1.5 years compared to girls from the United States and Europe. The progression of compensated hypertrophy to heart failure (HF) is still debated. C1-C2 instability or subluxation was present in 66/82, subaxial subluxations in 27/82 and atlantoaxial impaction in 10/82 procedures (data partly missing in one case). There are often substantial drawbacks, however, such as drug-induced toxicity and high costs of treatment.

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Transgenerational effects of obesity and malnourishment on diabetes risk in F2 generation. Louis encephalitis virus in southern Florida should consider increased biting rates on sentinel chickens and the consequences for the interpretation of sentinel seroconversion data. Among the APs, 4-t-octylphenol and 4-nonylphenol were found to be considerably more potent than any other compound and estrogenic effects were detectable at 1 and 10 microM, respectively. The possible adverse effects of exercise, hypoglycemia and excessive rise in counterregulatory hormones can be largely avoided by adequate insulin therapy. U-II level was not different with regard to gender in either group. Additional studies will have to provide a solid basis for the recommendation of mutation analysis in non-familial steroid-resistant focal-segmental glomerulosclerosis. The amplified pulse was frequency-doubled by second-harmonic generation, producing a 0.5-mJ pulse with no background emission.

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The toxicity of TLR9 agonists is generally acceptable, except when the agonist is combined with immunosuppressive agents in patients with advanced non-small-cell lung cancer. Cost-effectiveness of FDG-PET for the management of solitary pulmonary nodules: a decision analysis based on cost reimbursement in Germany. Many of the ways in which isotopes are used in biomedical research are reviewed. Consequently, it has a flat performance characteristic, correlated with data variation rather than file size. An electromechanical spinal model can be used as training tool along with an oscilloscope. Relation between bicarbonate concentration and voltage dependence of sodium currents in freshly isolated CA1 neurons of the rat. Toxicity and/or insufficient analgesia by opioid therapy: risk factors and the impact of changing the opioid.

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A tracheobronchial injury is an uncommon complication of an esophagectomy. The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa. the findings indicate that the average nursing care time was 29.5 hours, consisting of 27.4 hours of direct care and 2.1 hours of indirect care per patient/day. The method of deriving guidelines from the theory was focus group interviews. The two replication origins are composed of three characteristically arranged DnaA boxes and an AT-rich stretch, and the oriC in the circular chromosome is followed by the dnaN gene. TNF-alpha and NOS2 gene expression is regionally upregulated in hibernating myocardium to a level intermediate between that of normal regions and ischemic regions without contractile reserve. PubMed, Embase, Web of Science, Scopus, African Index Medicus (AIM), Latin American and Caribbean Health Sciences Information System (LILACS), Index Medicus for the Eastern Mediterranean Region (IMEMR), Index Medicus for the South-East Asian Region (IMSEAR), and Western Pacific Region Index Medicus (WPRIM).

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University of Wisconsin, HTK, and Celsior solutions all provide similar allograft outcomes in most clinical trials, but subtle differences have become more apparent in the recent studies and registry reports. Bacterial species such as Pseudomonas, Burkholderia, and Stenotrophomonas are intrinsically resistant to many antibiotics and as such it is of interest to investigate if the use of streptomycin provided a selective advantage for these bacteria in the soil ecosystem. Two techniques with methylene blue were used to identify the minor papilla and its orifice more clearly in a series of patients: spraying methylene blue over duodenal mucosa in the region suspected to contain the minor papilla with/without secretin or cholecystokinin agonist administration, and injection of contrast medium containing methylene blue into the ventral pancreatic duct by means of the major papilla in cases of incomplete pancreas divisum. Using RNA-sequencing-derived databases with this Global Post-Translational Modification (G-PTM) search strategy revealed hundreds of single amino acid variant peptides, tens of novel splice junction peptides, and several hundred posttranslationally modified peptides in each of ten human cell lines. We demonstrate that a quenching of structural fluctuations is achieved once the proteins find a stationary plateau maximizing the number of highly protected hydrogen bonds. From its behavior in pulsed field gel electrophoresis, FISH analysis of stretched DNA fibers, and its appearance under scanning confocal microscopy, it was concluded that the SAC is a circularized and multimerized derivative of the original YAC.

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These observations on arterial lipid metabolism provide sufficient justification for further studies directed towards characterizing the effects of oral hypoglycemic agents on the various aspects of arterial wall metabolism. We report that in human melanoma cells, cisplatin-induced calpain activation occurs early in apoptosis. These findings provide new perspectives to enhance the ability of cellulolytic bacteria to produce biofuels and biocommodities with high efficiency and at low cost directly from lignocellulosic biomass. To examine the role of the CD28-CD80-CD86 pathway of T-lymphocyte costimulation in corneal allograft rejection and the effect of blockade of that pathway on graft survival. Copper significantly reduced the proportion of zinc taken up from the perfusate, and concomitantly limited the passage of zinc into the circulation and beyond. Effect of two antibiotics (23-21 and 1779) on experimental tumors.

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Bcl-2 expression identifies patients with advanced bladder cancer treated by radiotherapy who benefit from neoadjuvant chemotherapy. In perigonadal adipose tissue, the expression of numerous genes involved in lipid metabolism was differentially regulated. The subjects were surveyed using the Pittsburgh Sleep Quality Index (PSQI), the modified Kupperman Index (KI), and a general questionnaire to obtain sociodemographic data. Parkinsonism and Epilepsy: Case Report and Reappraisal of an Old Question. This disorder is characterized by fever and some painful attacks such as abdominal, chest or joint pain and potentially development of AA amyloidosis. A biopsy was performed under the diagnosis of a retropharyngeal tumor. Symptomatic lactic acidosis requiring intensive lopressor cost care is a rare and severe adverse event related to the mitochondrial toxicity of the nucleoside analog reverse transcriptase inhibitors (NRTIs). Family history of mental illness may increase the vulnerability to drug-induced psychotic symptoms. Nitro-based compounds are the direct precursors of trichloronitromethane during chlorination disinfection. Intracoronary thrombolysis using urokinase in acute myocardial infarct.

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