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Avdol (Tramadol)

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Avdol is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Avdol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine.

Other names for this medication:
Adamon, Anatram, Axedol, Bludol, Bolodol, Cadol, Combitram, Damol, Didol, Domadol, Haledol, Ibudol, Ivydol, Jpdol, Leedol, Mandol, Movon, Muzox, Nobligan, Nopidol, Nosdol, Opiran, Paintrol, Ramax, Ramcet, Simol, Soztram, Spasteez, Supridol, Tolydol, Tramacon, Tramasol, Tramazol, Trambax, Tramex, Tranzat, Trapain, Tremtec, Ultracon, Ultraspas, Urgendol, Vardol, Zamadol

Similar Products:
Actos, Requip, Rocaltrol, Geodon, Maxolon, Levothroid, Leukeran

Also known as: Tramadol


{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Avdol ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Avdol ER.

Never share Avdol ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Avdol ER.

Avdol ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Avdol ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Avdol ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Avdol ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Avdol ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

After you prime the bottle, there will only be 120 doses or sprays. Keep track of the number of sprays you use. Throw the bottle away after you use 120 sprays even if some liquid remains in the bottle.

Detailed Avdol dosage information

Side effects

The most common side effects associated with Avdol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Avdol ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Avdol ER should not be given to a child younger than 12 years old. Avdol ER should not be given to anyone younger than 18 years old.

Do not give Avdol ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Avdol ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Avdol ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Avdol ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Heightened interferon-alpha/beta response causes myeloid cell dysfunction and promotes T1D pathogenesis in NOD mice. Insulin on the other hand stimulated two waves of doubling of DNA synthesis during 6 culture days. The hemolytic uremic syndrome (HUS) as the terminal stage of a generalized vascular disease with Raynaud phenomena. The aim of this study was to establish sol-gel technique of coating titanium on the surface of Ni-Cr alloy (PFM) in order to enhance corrosion resistance and reduce corrosive rate in oral cavity. The word identification process is conceptualized with regard to visually accessible morphographic components of text, including definition of the variables involved in morphographic analysis. Local schemes for the complex utilization and protection of the water resources of the riverine and marine basins of the Northern Caucasus. The patients with arterial hypertension under treatment at the university hospital had a profile of high cardiovascular risk and poor blood pressure control. A STUDY OF THE TOXICITY OF DIPHTHERIA BACILLI ISOLATED FROM IMMEDIATE CONTACTS. There is evidence that anaerobic methane oxidation with sulfate proceeds at least in part via reversed methanogenesis involving the nickel enzyme methyl-coenzyme M reductase for methane activation, which under standard conditions is an endergonic reaction, and thus inherently slow.

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Development of genotype-independent regeneration system for transformation of rice (Oryza sativa ssp. Data from UK sources on asbestos disease types recorded in 2000 and their disease treatment costs were obtained. Most high-titer, high-thermal-amplitude, complement-activating cold agglutinins are associated with hemolytic anemia. Using fMRI, we studied the brain reaction in 20 subjects to violation of face, space (inherited), and artifact (acquired) concepts by presenting them with deformed faces, impossible figures (i.e., impossible chairs), and deformed planes, respectively, as well as their normal counterparts. We demonstrate that 4-hydroxy-2-nonenal (HNE), a product of lipid peroxidation, and a structurally related compound, trans-retinal, stimulate a proton conductance in potato mitochondria that is inhibitable by GTP (a characteristic of UCP). Comprehensive review and compilation of pretreatments for mesophilic and thermophilic anaerobic digestion.

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Thus, by inducing EC apoptosis, MCs may contribute to plaque erosion and complications of atherosclerosis. Transconjugants isolated on the basis of resistance to ampicillin did not acquire any other resistant markers. Rescue of the amrAB-oprB region from a 708a fosmid library and sequencing showed the presence of a large chromosome 1 deletion (131 kb and 141 kb compared to strains K96243 and 1710b, respectively). Serum HMGB1 concentrations were measured using enzyme-linked immunosorbent assays (ELISA). Evidence based medicine (EBM) is considered an integral part of medical training, but integration of teaching various EBM steps in everyday clinical practice is uncommon.

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Study of lamotrigine efficacy on behavior disorders affecting patients with severe mental retardation. With only one exception the contrast medium was found intracranially with preference to the sella and to the region of the frontobasis. Restimulation of long-term bovine mixed leucocyte cultures with the original stimulator population revealed responder cells demonstrating augmented alloantigen-specific lytic activity. Our results suggest that SOX2 is important in the upregulation of gastric foveolar mucin, MUC5AC in colorectal mucinous and signet ring cell carcinomas. These structures provide insights into how the molecular switch that may allow communication between tRNA and mRNA binding sites is formed and illustrate how RNA acts as an activator of the switch. Combining pediocin with postpackaging irradiation for control of Listeria monocytogenes on frankfurters. Experimental results are analyzed using theoretical models represented by the flat Au(111) and the kinked Au(321) slabs with Ag impurities. Data suggest pesticide-induced injury can occur very early in development and at concentrations predicted without health consequences.

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brucei contains multiple domains of extensive editing and is homologous to a subunit of NADH dehydrogenase. Prevalence of squamous abnormalities in women with a recent smear without endocervical cells is lower as compared to women with smears with endocervical cells. Most minor side effects of ablation in the right atrium and right ventricle relate to femoral venous catheterization but there is a small risk of severe complications including atrioventricular (AV) block, damage of surrounding structures and thromboembolic events. Low dose noncontrast computerized tomography is becoming a common imaging tool to diagnose urolithiasis. Our study shows a consistent trend that the porosity increases with the increasing wafer conductivity (dopant concentration) and oxidant (H(2)O(2)) concentration.

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At present, an implantable cardioverter-defibrillator (ICD) is the recommended therapy in high-risk patients. The oral use of the enzymes or their introduction directly into the duodenum simultaneously or 30 minutes before the antibiotic administration did not increase the morphocycline and streptomycin levels in the biosubstrates tested. The predicted behavior is robust against detuning between the resonant frequencies of gain and absorbing medium. VCO2 and VO2 measured at the mouth ((VCO2)E, (VO2)E) and estimated at the alveolar level ((VCO2)A, (VO2)A) were computed breath-by-breath. Perforating injuries of the soft palate in childhood are generally uncomplicated. Nevertheless, we failed to find the conserved viral late domain motif, which is required for interaction with the ESCRT component, in the HCV-JFH1 Core, suggesting that HCV Core has a novel motif required for HCV production. Socioeconomic position, race/ethnicity, and inflammation in the multi-ethnic study of atherosclerosis. However, because of the profound effects of human immunodeficiency virus (HIV) coinfection on HCV, it is not clear if these observations are also true for HCV/HIV-coinfected individuals. Temporal synergism of neurotransmitters (serotonin and dopamine) affects testicular development in mice.

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Pharmacological manipulation of fetal hemoglobin synthesis in patients with severe beta-thalassemia. The potential advantages of regional anesthesia include minimal airway intervention, less cardiopulmonary depression, excellent postoperative analgesia, less postoperative nausea and vomiting, and shorter recovery room and hospital stays. Various approaches that seek to address some or all of these limitations are described, including techniques that utilize (a) iterative temporal smoothing, (b) advanced temporal basis functions, (c) principal components transformation of the dynamic data, (d) wavelet-based techniques, as well as (e) direct kinetic parameter estimation methods. Structuring and interactions of human beta-defensins 2 and 3 with model membranes. Rescaling generic models is the most frequently applied approach in generating biomechanical models for inverse kinematics. The hygienists at the time of the blockade of the Leningrad front. In the current study, we investigated the histology of the interface between craniopharyngiomas and surrounding normal structures such as the hypothalamus and pituitary gland. Demonstration of cross-sectional selectivity of the activation awaits further methodological and experimental refinements. Prolonged spasm of the arteries of the base of the brain during experimental fibrinolysis in the subarachnoid space. We study the accuracy of the Perdew, Burke, and Ernzerhof (PBE) generalized-gradient approximation to DFT in the description of these systems and the origin of the experimentally observed large dependence of the (17)O chemical shift on the alkaline earth ion.

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Cascade approach to substituted 6-aryl-phenanthridines from aromatic aldehydes, anilines, and benzenediazonium-2-carboxylate. Albumin coating resulted in a faster healing : cells appeared earlier and collagen development was greater. The aim of this study is to assess the current levels of experience in trauma management and attitudes towards adequacy of exposure amongst current trainees in New Zealand. These membranes were employed for developing a simple membrane process for pH sensitive protein fractionation under coupled driving forces (pressure and electric gradient). However, OPF might not be the appropriate device for every individual with TFA, due to varying bone compositions, co-morbidities, and limited clinical experience and unknown long-term effects. In vitro approaches used isolated rat intestinal tissues (duodenum, jejunum, and ileum). While level sets have demonstrated a great potential for 3D medical image segmentation, their usefulness has been limited by two problems. Moreover, further alkyne transformations occur at temperatures from 50 to 90 degrees C below what is needed to convert a control compound without the heterocycles.

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A polyclonal antiserum against a trpE fusion protein containing the complete open reading frame of the polyhedron envelope (PE) protein from the nuclear polyhedrosis virus of Orgyia pseudotsugata (OpMNPV) was used for immunogold staining and electron microscopic examination of polyhedra, isolated polyhedron envelopes, and infected insect cells at selected times postinfection. Our results suggest the lack of a direct relationship between the critical concentration of free drug at which condensation of DNA occurs and the cytotoxic and anti-cancer properties exhibited by the various anthracycline derivatives. The three enzymes were resolved into separate fractions by chromatography on three dye-ligand affinity resins, which are specific for nucleotide binding enzymes and have a high protein binding capacity. These events provide a rapid kinin-dependent mechanism for 1) regulating the constitutive B1R activity and 2) shifting the balance of accessible receptors in favor of B1R. The present study evaluated the effects of an electronic alert to the responsible physician in a cohort of hospitalized high-risk patients not receiving VTE prophylaxis. Hog1 interacts physically with Sic1 in vivo and in vitro, and phosphorylates a single residue at the carboxyl terminus of Sic1, which, in combination with the downregulation of cyclin expression, results in Sic1 stabilization and inhibition of cell-cycle progression. Swine dust exposure is a model for rapid induction of non-allergic neutrophil inflammation in the nasal mucosa of healthy volunteers, and the symptoms as well as the microcirculation are modified by nasal lavage.

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Twenty-four of 42 RVLM and 12 of 21 NTS units were classified as cardiovascular because they were inhibited by baroreceptor activation and displayed a cardiac rhythm. Determination of lead and cadmium using a polycyclodextrin-modified carbon paste electrode with anodic stripping voltammetry. No association of TLR2 and TLR4 polymorphisms with type I diabetes mellitus in the Basque population. L-arginine protects the mesenteric vascular circulation against cardiopulmonary bypass-induced vascular dysfunction. Gaps exist in our information diamox 250 mg pill about diabetes and obesity in Arab populations in relation to ethnic-specific cut-off points for diagnosis and treatment of diabetes.

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We could thus establish an in vitro intestinal model to study the mechanism of NPC1L1-dependent sterol uptake and to screen drug candidates whose target is NPC1L1. Circulating VEGF levels were measured immediately before and after laparoscopic colon surgery in 10 unselected sequential patients with a diagnosis requiring surgical intervention for colon pathology. The cyclic peptide, peptide B, which contains the CAR sequence of occludin, increased neutrophil chemotaxis in a time and dose dependent manner. A histological study of the anti-inflammatory effect of helium-neon laser in models of arthropathies induced by hydroxyapatite and calcium pyrophosphate in rats. One was a middle-aged woman who had targetoid lesions and bullae on her trunk and extremities. The relationships between biological parameters and each index of the MD method were analyzed using multivariate analysis. Genotypic relatedness of strains was investigated by pulsed-field gel electrophoresis (PFGE) analysis of digested genomic DNA. Accessory reproductive gland proteins (Acps) in Drosophila evolve quickly and appear to play an important role in ensuring the fertilization success of males. The present study suggests that administration of spectinomycin at the dose levels recommended for single-dose treatment of gonorrhea (2 or 4 g) most probably is free rulide drug from ototoxic effect.

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Some cases may require specific restorative procedures, while others will not require treatment. A description of the side-chains and nucleotides proposed to be involved in the discrimination process is provided. The availability of timed midterm pregnancies made it possible to examine the organization of the placenta, the distribution of regions of columnar trophoblast and the nature of the heterophagous and hemophagous regions in well-preserved material. The coefficient isocontour maps obtained from these models were compatible with the geometrical and physicochemical properties of AChE. Autometallography (AMG) was applied for tracing mercury in long-finned pilot whales (Globicephala melas) harvested in the Faroe Islands. Cell type heterogeneity of cytokeratin expression in complex epithelia and carcinomas as demonstrated by monoclonal antibodies specific for cytokeratins nos. In contrast, minimum inhibitory concentrations for Pseudomonas and Proteus spp. Although some of these proteins seem to be shared by all major groups of metazoa, others are restricted to certain evolutionary lineages. Therefore, we believe that spectral analysis of individual cells can aid cytology in rendering reliable diagnoses based on objective measurements and discriminant algorithms.

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Trimester-specific normative data and normal ranges from different geographic regions do not exist. The phylogeny of adhesion among cells derived from neural tissue has been examined using a combination of functional and immunological analyses. Conflicts in the ICU: perspectives of administrators and clinicians. These intermediates are nonemitting but are still able to quench the fluorescence of the donor at a distance scale shorter than conventional fluorescence resonance energy transfer, suggesting novel biophysical applications. The present results suggest that AS601245 reduced damage to neurites and decreased astrogliosis following global ischaemia and also improved long-term memory, supporting JNK inhibition as a promising therapeutic strategy for ischaemic insults to the CNS. The lymphocyte stimulation by PHA showed considerable variation dependent on the phase of therapy. The system has been optimized to deliver, at a high repetition rate, subnanosecond pulses at the wavelength 355 nm with an energy per pulse of close to 1 muJ (38-mW average power). Reciprocal gut-brain evolutionary symbiosis provokes and amplifies the postinjury systemic inflammatory response syndrome. The constellation of executive dysfunction, low adaptive level, high medication load, and a history of several failed AEDs are risk factors for poor HRQOL in children with epilepsy.

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An N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) that catalyzes formation of NAEs was recently identified as a member of the zinc metallohydrolase family of enzymes. Symposium for experimental orthopedics at the Orthopedic Clinic of the Ludwig-Maximilians will tetracycline cure a bladder infection University Munich. Cyclosporine pharmacological efficacy estimated by lymphocyte immunosuppressant sensitivity test before and after renal transplantation. This method can be generalized to perturbations of systems that have a polynomial integral factor (like the Lotka-Volterra equation). Implications of unobserved heterogeneity and endogeneity of lifestyle outcomes on health were investigated. The aim of this study was to investigate the effect of oxidoreduction potential (Eh) on the biosynthesis of aroma compounds by lactic acid bacteria in non-fat yogurt.

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Mechanical thrombectomy in acute proximal middle cerebral artery thrombosis with the alligator retrieval device. Due to overlaps between routine and research documentation, a single source approach provides opportunities to improve efficiency of medical documentation given the large workload of physicians related to documentation. Ultrafast energy transfer from bound tetra(4-N,N,N,N-trimethylanilinium)porphyrin to synthetic dopa and cysteinyldopa melanins. We employed both commonly used pathologic techniques, such as hematoxylin-eosin staining and immunohystochemistry, both fluorescence in situ hybridization on paraffin-embedded tissue sections using probes for atenolol brand chromosomes X and Y. The molecular mechanisms underlying this response are not well understood, however, and the spectrum of CBZ-inducible genes in human liver has not been thoroughly investigated. The initial two-component sensor kinase protein LuxQ, and the terminal response regulator luxO are found in most Proteobacteria, as well as in some Firmicutes, often in several copies. Tissue reaction to sutures was studied in 666 specimens obtained from patients from one day to 23 years after operation.

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