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Asacol (Mesalamine)
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Asacol

Asacol is used to treat a certain bowel disease (ulcerative colitis). It helps to reduce symptoms of ulcerative colitis such as diarrhea, rectal bleeding, and stomach pain. Asacol belongs to a class of drugs known as aminosalicylates. It works by decreasing swelling in the colon.

Other names for this medication:
Canasa, Mesacol, Mesalamine, Pentasa, Rowasa, Tidocol, Walasa

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Also known as: Mesalamine

Description

{name} HD (mesalamine) affects a substance in the body that causes inflammation, tissue damage, and diarrhea.

{name} HD delayed-release 800mg tablets are used to treat moderately active ulcerative colitis in adults.

Dosage

This section provides information on the proper use of a number of products that contain mesalamine. It may not be specific to Asacol 800. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Do not stop using this medicine without checking first with your doctor.

Keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. Do not miss any doses.

Swallow the capsule or tablet whole. Do not open, break, crush, or chew it.

If you are taking the Asacol® delayed-release tablet:

You may take this medicine with or without food. Drink extra fluids so you will urinate more often and help prevent kidney problems (eg, kidney stones).

Take the Asacol® HD tablet on an empty stomach, at least 1 hour before or 2 hours after a meal.

You should take the Lialda® tablets with food. All other brands of capsules and tablets can be taken with or without food.

If you have trouble swallowing the Delzicol® capsule, carefully open the capsule and take out the 4 tablets. Swallow the tablets whole and make sure all 4 are taken at the same time as one dose. Do not cut, break, crush, or chew them.

The contents of the Pentasa® capsule may be sprinkled onto soft foods (eg, applesauce or yogurt) if you have trouble swallowing the capsule. The mixture must be swallowed right away without chewing.

If you are taking the delayed-release capsule, extended-release capsule, or delayed-release tablet, part of the capsule or tablet may pass into your stool after your body has absorbed the medicine. Contact your doctor if this happens more often than 1 or 2 times.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For the treatment of ulcerative colitis: For long-acting oral dosage form (delayed-release capsules): Adults—800 milligrams (mg) 3 times a day. Children 5 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually not more than 2400 mg per day, divided in 2 doses. Children younger than 5 years of age—Use and dose must be determined by your doctor. For long-acting oral dosage form (delayed-release tablets): Asacol®: Adults—800 milligrams (mg) (two 400 mg tablets) 3 times a day for 6 weeks. Children 5 years of age and older—Dose is based on body weight and must be determined by your doctor: Weighing 54 to 90 kilograms (kg)—1200 mg (three 400 mg tablets) in the morning, then 1200 mg (three 400 mg tablets) in the afternoon for 6 weeks. Weighing 33 to less than 54 kg—1200 mg (three 400 mg tablets) in the morning, then 800 mg (two 400 mg tablets) in the afternoon for 6 weeks. Weighing 17 to less than 33 kg—800 mg (two 400 mg tablets) in the morning, then 400 mg (1 tablet) in the afternoon for 6 weeks. Children younger than 5 years of age or weighing less than 17 kg—Use and dose must be determined by your doctor. Asacol® HD: Adults—1600 milligrams (mg) 3 times a day for 6 weeks. Children—Use and dose must be determined by your doctor. Lialda®: Adults—2.4 to 4.8 grams (g) once a day. Children 5 years of age and older—Dose is based on body weight and must be determined by your doctor: Weighing more than 50 kilograms (kg)—4.8 grams (g) once a day for 8 weeks. Then 2.4 g once a day. Weighing more than 35 to 50 kg—3.6 g once a day for 8 weeks. Then 2.4 g once a day. Weighing 24 to 35 kg—2.4 g once a day for 8 weeks. Then 1.2 g once a day. Children younger than 5 years of age or weighing less than 24 kg—Use and dose must be determined by your doctor. For long-acting oral dosage form (extended-release capsules): Adults— For Apriso®: 1.5 grams (g) (four capsules) once a day as a single dose in the morning. For Pentasa®: 1 g (four 250 milligrams [mg] capsules or two 500 mg capsules) 4 times a day. Children—Use and dose must be determined by your doctor. For prevention of ulcerative colitis: For long-acting oral dosage form (delayed-release capsules): Adults—1600 milligrams (mg) per day, taken in divided doses. Children—Use and dose must be determined by your doctor. For long-acting oral dosage form (Asacol® delayed-release tablets): Adults—1600 milligrams (mg) (four 400 mg tablets) per day, taken in 2 to 4 divided doses. Children—Use and dose must be determined by your doctor. For long-acting oral dosage form (Lialda® delayed-release tablets): Adults—2.4 grams (g) once a day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Asacol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the delayed-release capsules and delayed-release tablets in a tightly-closed container to protect them from moisture.

Detailed Asacol dosage information

Side effects

The most common side effects associated with Asacol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Asacol HD if you are allergic to mesalamine, aspirin, sulfasalazine, or salicylates (such as Disalcid, Doans Pills, Dolobid, Kaopectate, Nuprin Backache, Pepto-Bismol, Tricosal, Trilisate, and others).

To make sure Asacol HD is safe for you, tell your doctor if you have ever had:

a kidney stone or kidney disease; liver disease; a blockage in your stomach or intestines (such as pyloric stenosis); or a skin condition such as eczema.

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether mesalamine will harm an unborn baby. However, having untreated or uncontrolled ulcerative colitis during pregnancy may cause complications such as low birth weight or premature birth. The benefit of treating ulcerative colitis may outweigh any risks to the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. If you are breastfeeding, tell your doctor if you notice diarrhea in the nursing baby.

Do not give this medicine to a child. Asacol HD is not approved for use in anyone younger than 18 years old.

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In this protocol, we describe the reconstitution of ATP-driven lipid flippases in liposomes and the analysis of their in vitro flippase activity based on the use of fluorescent lipid derivatives. Clinical features and functional outcome of intracerebral hemorrhage in patients aged 85 and older. Reverse transcription-polymerase chain reaction (RT-PCR) assay for ET-1 mRNA and ET01 immunohistochemistry (IHC) were performed at PODs 7 and 90. Regulation of the respiratory central pattern generator by chloride-dependent inhibition during development in the bullfrog (Rana catesbeiana). Mandibular rest levels with and without dentures in place in edentulous and complete denture-wearing subjects. To exclude vasotec dosage a technical artefact, we repeated measurements of central venous COHb and arterial COHb in healthy humans (ASA I-II) undergoing elective surgery with the ABL 625 and the updated version, ABL 725 (Radiometer, Copenhagen). Elevation of temperature, white cell count, ESR and CRP were useful indicators of septic arthritis but initial diagnosis must be made on a clinical basis. Isolated granulomatous phlebitis seems to be self-limited, and its cause is unknown.

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In the exercised animals, an increase in water content and a sharp decrease in HP crosslinking was found that was correlated with the presence of wear lines. CER uses a broad spectrum of methodologies is generic metformin as good as glucophage including randomized pragmatic trials that can also be applied to herbal whole system therapies. Studies and interpretation of the position of the bite plane and occlusal tooth surface to the ear-nose plane from the prosthodontic viewpoint. This indicated a performance trade-off between the stability of pre-tension and RTs. Surgical resection of the tumor and injection of corticosteroid should be performed for polypoid-type laryngeal sarcoidosis. Nineteen lymph node paraffin blocks were collected from 1994 to 2007.

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These results support an essential role for retinoid signaling between the late gastrula and early somite stages in the rat embryo for normal morphogenesis of the primitive heart tube and the posterior hindbrain. A albenza tablet double-blind trial of budesonide and betamethasone- 17,21-dipropionate in psoriasis. Use of this conjugate permitted direct purification, by affinity chromatography, of the two molecular forms of acetylcholinesterase, 14 and 18 S, present in fresh electric organ tissue. Idiopathic hypertrophic pachymeningitis: a report of two patients and review of the literature. Cortactin was localized to active lamellipodia and to small cytoplasmic spots. Further studies suggested that tBHQ increased the nuclear accumulation of Nrf2 and the Nrf2-regulated gene expression, including heme oxygenase-1 (HO-1) and. Although previous studies have contributed to the knowledge of carcinoma of pancreas epidemiology, such association needs to be further verified with proper epidemiological work. We determined the effect of alcohol intake on rates of myofibrillar protein synthesis (MPS) following strenuous exercise with carbohydrate (CHO) or protein ingestion. This retrospective study was approved by the institutional review board, with waiver of informed consent.

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Our study was done in a randomized, placebo-controlled, double-masked, three-way crossover design. SUMMARY OFF BACKGROUND DATA: Because thoracoscopy is relatively new and technically demanding, many surgeons ligate the segmental blood vessels to enhance spine exposure and limit the risk of injury during discectomy and fusion. Theoretical weights (TWs) of split tablets of the same medications were determined mathematically. The serotonin (5-HT) deficiency hypothesis of aggression is being seriously challenged by pharmacological data showing robust anti-aggressive effects of 5-HT1A receptor agonists in dose ranges that concomitantly inhibit 5-HT neurotransmission. Using measurements of gelation kinetics from multiple particle tracking microrheology (MPT), we correlate the material rheology with the the formation of stable fibers. 17betaHSD1 is an attractive drug target in hormone-sensitive breast cancer. However, the long-term outcomes of patients who undergo incident hemodialysis and subsequently develop retinal vascular occlusion have not been examined.

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This was documented by the presence of CMV early antigen, antibodies and evidence of CMV in the colonic mucosa. Workup revealed a possible hypercoagulable state due to an anticardiolipin antibody. Thus, the more convenient use of a premounted stent provides procedural safety and efficacy comparable with a hand-crimped system. Clinical-neurological and neuropsychological investigations, as well as cranial computerized tomography (CT) and electroencephalography (EEG) were performed in 33 patients suffering from verified post-traumatic epilepsy. Serum sodium and potassium ions concentration were determined by flame photometry. Injection of thioglycolate medium significantly decreased the ability of the host to resist infection. Social behavior was operationalized in terms of the duration and frequency of visual and verbal behavior elements and scored during a conversation and a play segment. In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). Muscle-in-vein conduits are used alternatively to nerve grafts for bridging nerve defects. Attention bias and anxiety in young children exposed to family violence.

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To assess the efficiency and safety of hydroxyurea in patients with sickle cell disease from the Eastern Province, Kingdom of Saudi Arabia. We have found aspiration cultures to be valuable in patients 1) with indwelling urethral catheters, 2) who fail to respond to initial antimicrobial therapy, 3) who have epididymitis found on surgical exploration for torsion of the teticle and 4) with recurrent epididymitis in whom the etiologic agent is uncertain. Regurgitation of blood flow from the ectatic LAD artery as a cause of angina demonstrated during coronary angiogram. A quantitative histologic analysis of the growing long bone metaphysis. Social workers and subbstance-abusing clients: caseload composition and competency self-ratings. Surgical treatment may be better than conservative treatment for patients with primary patellar dislocation on incidence of redislocation. Therefore, MOGEN is a useful tool for converting chromosomal contact data into 3D genome models to provide a better view into the spatial organization of genomes. Characterization of Cr(VI) binding and reduction to Cr(III) by the agricultural byproducts of Avena monida (oat) biomass. This cross-sectional study was conducted at Department of Obstetrics and Gynaecology, Khyber Teaching Hospital, Peshawar and Department of Anatomy, Khyber Medical College, Peshawar from January 2008 to March 2009. Investigations of the clinical value of the polarographic method.

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