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Aripra

Aripra is an antipsychotic medication. It works by changing the actions of chemicals in the brain. Aripra is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar I disorder (manic depression).

Other names for this medication:
Apicord, Aridus, Arifril, Arilan, Arinex, Aripat, Aripicon, Aripiprazole, Aripra, Arpicin, Asprito, Biliff, Elrip, Pipra, Rizotal, Schizopra

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Also known as: Aripiprazole

Description

Aripiprazole is used alone or together with other medicines to treat mental conditions such as bipolar I disorder (manic-depressive illness), major depressive disorder, and schizophrenia. It is also used in children to treat irritability associated with autistic disorder and Tourette syndrome. Aripiprazole works in the brain to change how certain chemicals affect patients. It is an antipsychotic agent.

This medicine is available only with your doctor's prescription. {name}® oral solution was withdrawn from the market on May 15, 2015 and this dose form is not marketed by any generic manufacturers.

Dosage

This section provides information on the proper use of a number of products that contain aripiprazole. It may not be specific to Aripra Mycite. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may swallow or take a sip of water.

Swallow the tablets whole. Do not break, crush, or chew them.

Aripra Mycite® has a sensor in the tablet, which helps track it inside the stomach or bowels. The Aripra Mycite® System comes with a patch (wearable sensor), a smartphone application (app), and a web-based portal. Follow your doctor's instructions on how to use the medicine.

The Aripra Mycite® tablet is usually detected within 30 minutes after you take it, but there may be a delay of more than 2 hours for the smartphone app and web portal to detect that you have taken the medicine, and sometimes it might not be detected at all.

To apply the Aripra Mycite® patch:

The app will tell you when to apply or remove the patch. It should be changed weekly or sooner as needed. Place the patch to the left side of your body just above the lower edge of your rib cage. Do not put the patch in areas where the skin is scraped, cracked, inflamed, or irritated, or near the area where you had removed the previous patch. The app will help you place the patch in the correct location. You may keep the patch on when showering, swimming, or exercising.

Aripiprazole may be taken with or without food. If your doctor tells you to take it a certain way, follow your doctor's instructions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets and orally disintegrating tablets): For bipolar mania: Aripra® and Aripra Discmelt®: Adults—At first, 15 milligrams (mg) once a day. When it is given with lithium or valproate, the starting dose is 10 to 15 mg once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children 10 years of age and older—At first, 2 mg once a day. The dose will be gradually increased to 10 mg once a day. Your doctor may adjust your dose again as needed. However, the dose is usually not more than 30 mg per day. Children younger than 10 years of age—Use and dose must be determined by your doctor. Aripra Mycite®: Adults—At first, 15 milligrams (mg) once a day. When it is given with lithium or valproate, the starting dose is 10 to 15 mg once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children—Use and dose must be determined by your doctor. For depression: Adults—At first, 2 to 5 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 15 mg per day. Children—Use and dose must be determined by your doctor. For irritability in children with autistic disorder: Children 6 to 17 years of age—At first, 2 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 15 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor. For schizophrenia: Aripra® and Aripra Discmelt®: Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children 13 to 17 years of age—At first, 2 mg once a day. The dose will be gradually increased to 10 mg once a day. Your doctor may adjust your dose again as needed. However, the dose is usually not more than 30 mg per day. Children younger than 13 years of age—Use and dose must be determined by your doctor. Aripra Mycite®: Adults—At first, 10 to 15 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 30 mg per day. Children—Use and dose must be determined by your doctor. For Tourette's disorder: Children 6 to 18 years of age—At first, 2 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, vomiting, aggression, confusion, tremors, fast or slow heart rate, seizure (convulsions), weak or shallow breathing, fainting, or coma.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Aripra MyCite dosage information

Side effects

The most common side effects associated with Aripra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of aripiprazole in children younger than 13 years of age with schizophrenia and in children younger than 10 years of age with bipolar disorder. Safety and efficacy have not been established.

Appropriate studies have not been performed on the relationship of age to the effects of Aripra Mycite® in children. Safety and efficacy have not been established.

Aripiprazole is not approved for use in children or teenagers with major depression.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of aripiprazole in children 6 to 17 years of age with autistic disorder.

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Cholinergic and serotonergic systems in the brain and spinal cord: anatomic organization, role in intercellular communication processes, and interactive mechanisms. X-ray studies on crystalline complexes involving amino acids and peptides. These difficulties are commonly attributed to the high sensitivity of F-actin to aldehyde fixatives. Hand ischemia due to traumatic arterial dissection proximal to hemodialysis fistula: endovascular treatment. We study the damping of internal waves in a viscous fluid near the liquid-vapor critical point. Androgen receptor mRNA regulation in adult male and female hamster facial motoneurons: effects of axotomy and exogenous androgens. The parasitic load rated by number of blood cells harboring parasites is high in young children, then diminishing in adults while the antibodies increased. The advantage of this activation strategy over the deactivation counterpart is that the activated catalyst can produce a greater enantiomeric excess in the products-even with the use of a catalytic amount of activator relative to chiral catalyst-than that attained by the enantiomerically pure catalyst on its own. Transcriptomes of post-mitotic neurons identify the usage of alternative pathways during adult and embryonic neuronal differentiation. Electrostatic correlations on the ionic selectivity of cylindrical membrane nanopores.

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Vascular endothelial function was evaluated in aortic rings through the relaxation response to acetylcholine (ACh). Socioeconomic status, human papillomavirus, and overall survival in head and neck squamous cell carcinomas in Toronto, Canada. Reproducibility and relative validity of the Food Frequency Questionnaire used in the ELSA-Brasil. Inverse age-dependent accumulation of decabromodiphenyl ether and other PBDEs in serum from a general adult population. Urocortin 2 But Not Urocortin 3 Promotes the Synaptic Formation in Hipppocampal Neurons via Induction of NGF Production by Astrocytes. Complex mechanisms maintain cholesterol within physiological ranges and the dysregulation of these mechanisms results in embryonic or adult diseases, caused by either excessive or reduced tissue cholesterol levels. In bone marrow transplant (BMT) recipients, the regimen of intestinal decontamination with metronidazole is targeted to anaerobic bacteria. A systematic process for inclusion, exclusion, appraisal, extraction and synthesis was undertaken. This study investigates how these two may be differentiated and inappropriate surgery, in particular inappropriate abdominoperineal excision, can be avoided. Sr4Mn2Cu5O4S5 contains manganese oxide sheets separated by unusual antifluorite-type Cu3S3 layers in which copper(I) ions are distributed over three- and four-coordinates sites in a similar fashion to in alpha-Cu2-xS and suggestive of high two-dimensional copper ion mobility.

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Therefore, iron supplementation in infants should be accompanied by measures to improve vitamin A status. This review provides a summary of the methods and tools available to quantify the thiol redox status of cells. Use of cervical ultrasonography in prediction of spontaneous preterm birth in triplet gestations. To compare the safety and efficacy of dexmedetomidine estrace vs generic estradiol cream /propofol (DP)-total i.v. Assuming the discharge of this radionuclide is maintained at a constant rate, the model shows that the concentration of 137Cs in the water and in the marine fish in the three sea compartments would become steady after 5 years. The determinants for psychological support were health insurance, and their current working status. In Study One, a purposive convenience sample of 399 Scottish parents answered questions on going to the dentist, family life and demographics. The treatment of perforated appendicitis in children often involves a combination of surgical and medical therapy. Seventy-two women with primary breast carcinoma were assigned randomly to a 12-week, web-based, social support group (Bosom Buddies). MicroRNAs and the cellular response to rapamycin: potential role in diagnosis and therapy.

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Similar rates of sentinel positivity are found when compared with those in whom their WLE was done concurrently. Direct calculation of the hard-sphere crystal /Melt interfacial free energy. This study was developed to assess whether health-related quality of life (HRQOL) scores also vary among patients of different ethnic backgrounds. Furthermore, these data suggest that, similar to adults with advanced congestive heart failure, the myocardial inflammatory cascade may contribute to the pathophysiology of congenital heart disease in infants and children. The outcomes continue to be suboptimal, and more effective therapies are needed because most patients had local or distant failure. Pulsed thermoelectrically cooled QC-DFB lasers operating at 15.6 micrometers were characterized for spectroscopic gas sensing applications. Highly efficient catalytic asymmetric epoxidation of allylic alcohols by an oxovanadium-substituted desloratadine 5 mg aurobindo polyoxometalate with a regenerative TADDOL-derived hydroperoxide.

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The upper-level students played the role of a patient, while they also practiced leadership, teaching, and mentoring of first-semester nursing students. The purpose of the present study was to evaluate the effects of acute and repeated treatment with two antidepressant drugs (ADs) of opposite pharmacological profile, i.e. Yet, recurrent structural and functional themes in mechanisms of action and resistance are observed among peptides of widely diverse source and composition. Although these lines are highly ER positive, a large number of tumors arising from these lines were ER negative and grew when implanted in ovariectomized mice. Endpoints included mean change in pain and sleep quality scores (Weeks 8 and 12), patient-reported outcomes, and adverse events (AEs). We also discuss some potential uses of the recoil shifts for these systems. Neither Ir-GLphi gene need be present in the proliferative T cell to generate an immune response to Poly(Glu55Lys36Phe9)n. Cardiac dysfunction is a frequent complication in critically ill patients and contributes to organ hypoperfusion and poor outcome. Enzyme inhibition as a possible cause can you drink alcohol with sporanox of secondary increases in metabolite levels in patients with inborn errors of metabolism. Triple therapies consisting of a proton pump inhibitor or ranitidine bismuth citrate and two antibiotics are the current standard of therapy for H.

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The simulation studies reveal that empirical density estimates are biased even for very large sample sizes. Australian New Zealand Clinical Trials Registry: ACTRN12613000190707 , registered on 18 February 2013. A redshift that is strongly dependent on pump power (45 meV microJ x cm(-2)) supports the idea that the electron-hole plasma mechanism is primarily responsible for the gain at room temperature. Subretinal neovascularisation, which tend to develop progressive visual loss, may be treated successfully with argon or krypton laser photocoagulation. All of them are zinc-dependent enzymes with highly similar zinc binding environments. Subretinal hemorrhages associated with angioid streaks following a mild ocular trauma.

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