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Aplatin (Clopidogrel)

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Aplatin is an antiplatelet medicine or a blood thinner that helps to prevent the formation of harmful blood clots in your blood vessels. This helps to lower the chances of you getting a heart attack or stroke. It is a widely used medicine for heart protection.

Other names for this medication:
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Also known as: Clopidogrel


Aplatin target is the treatment of heart attacks and strokes by preventing blood clots. It is also taken to prevent other heart or blood vessels disorders. Aplatin is acting by preventing blood clots. It is antiplatelet agents. Aplatin is also known as Clopidogrel, Clopitab, Caplor, Iscover, Clopilet, Ceruvin. Generic name of Aplatin is Clopidogrel. Brand name of Aplatin is Aplatin.


Take Aplatin at the same time every day, with or without food. Take Aplatin tablets orally with water. If you want to achieve most effective results do not stop taking Aplatin suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause excessive bleeding.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Aplatin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Aplatin if you are allergic to clopidogrel, or if you have:

any active bleeding; or a stomach ulcer or bleeding in the brain (such as from a head injury).

Tell your doctor if you have ever had:

an ulcer in your stomach or intestines; or a bleeding disorder or blood clotting disorder.

Aplatin may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure Aplatin is right for you.

This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

You should not breastfeed while using this medicine.

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Major impediments to progress are the homogeneity assumptions evident in many psychotherapy studies. Finally, we consider multi-qubit systems and discuss some aspects of decoherence. Daily changes in parameters of energy metabolism in brain of rainbow trout: dependence on feeding. Kinetic changes and modulation by carbamazepine on voltage-gated sodium channels in rat CA1 neurons after epilepsy. To determine whether insulin alone or combined with metformin lowers levels of hsCRP, IL-6, and soluble tumor necrosis factor receptor 2 (sTNFr2) in patients with recent-onset type 2 diabetes mellitus. On the potassium conductance increased by opioids in rat locus coeruleus neurones. Molecular characterization of the first intact Transib transposon from Helicoverpa zea.

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CX3CR1(GFP/GFP) mice express green fluorescent protein (GFP) in monocytes and macrophages and possess no functional CX3CR1. An impression of the defect was taken over the skin using impression compound first and then silicone impression material. Using this assay, we confirmed the genetic basis of Dun1 activation. This pilot study indicates that obese prepubertal children were able to reduce their fat intake to avoid gastrointestinal side effects. Increased inducible nitric oxide synthase in lung carcinoma of smokers. The introduction of the appropriate synergistic combinations for controlling the cholera in the endemic areas of Asia and Africa is suggested. These results suggest that beta-preprotachykinin is preferentially expressed in carcinoid tumors and that substance K may also play a role in the carcinoid syndrome. These results indicate that hand-sewn and mechanically stapled oesophagojejunostomy anastomoses allow the same high standard of performance. Trends in age-standardized rates over calendar period and trends of age-specific rates over birth cohorts are presented. Prospective study of the neuroprotective activity of sildenafil in a rat spinal ischemia model.

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The development of new and sophisticated techniques all aim to give reproductive technologies and scientists a better understanding of reproductive biology. For SIM characterization, AAC sensitivity is very high but has poor specificity, suggesting that histological confirmation is necessary when AAC is positive. The present study documents the school performance of 20 pediatric cochlear implant recipients who attended mainstream classes and compares their educational performance with their normally hearing peers. Both cases were transferred to combat support hospitals for further treatment after our initial assessment and treatment, and both had successful outcomes. Here, we report on one of the obtained antibodies (1D8), which recognized a surface epitope on hemocytes of the donor colony and other colonies, apparently in a manner specific to the Fu/HC genotype.

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Antihemagglutinin (HI) antibody response against each strain was measured before and one to six months after vaccination. We discuss the different proposed models for the mechanism of gene capture. The smallest complex, approximately 116 kDa, resulted from dimerization between two MYOC monomers. Effect of non-surgical periodontal therapy on patients with type 2 diabetes mellitus. Cognitive inflexibility and pre-frontal dysfunction in schizophrenia and mania. Whether psychotherapy plus pill placebo is the same as psychotherapy alone is an empirical question which however has to date never been examined systematically.

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A cutaneous biopsy specimen revealed Henoch-Schonlein vasculitis. Before chemotherapy, monocyte function in the patients was not different from that of normal controls. Moreover, the excitation band centred at 475.5 nm had a blue shift, but the excitation band at 437 nm changed relatively less due to induction of non-photochemical quenching (NPQ). The aim of the present study is to assess the prevalence of second primary tumors in patients treated for thyroid cancer. Imperfect hybrid layers created by an aggressive one-step self-etch adhesive in primary dentin are amendable to biomimetic remineralization in vitro.

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The results showed that the plasma FLV load was not proportional to the spleen index over the same FLV injection dosage series, although a trend was observed. Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism. These included 1 patient with a cavernous hemangioma, 2 patients with orbital varices, 1 patient with an orbitocutaneous arteriovenous malformation, and 1 patient who had a solitary fibrous tumor with features of a hemangiopericytoma. Minor adverse events were represented by sore throat sensation usually after prolonged exposure to salt (over 15 minutes continuously)--this improved promptly with temporarily discontinuation and no additional action was necessary. This suggests that at least some buried waters play a role in structural stabilization. Subsequent histochemical processing according to the tetramethylbenzidine procedure produces a unique, highly visible intraaxonal marker that makes the identification and 3-dimensional tracing of the sympathetic nerve fibers clear and unambiguous at both the light and electron microscopic levels. In differentiated muscle, hormonal and physiologic stimuli modify the expression of these proteins primarily at the level of transcription. This communication provides a synopsis of proteomics tools and delineates novel SELDI-TOF results to evaluate biomarkers in this regard. This method enables high-resolution studies over long time periods using fluorescent markers and confocal microscopy.

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Several drug targets have been identified which are either genes or proteins essential for the parasite survival and distinct from the hosts. Instead, both potential binding sites interact functionally with the C-terminal docking domain of the histone H2A. Potential risk of porcine endogenous retrovirus cross-species transmission in neonatal pig islets under xenotransplanted condition. No differences were revealed in the contents of dopamine and dihydroxyphenylacetic acid in the frontal cortex and amygdala. It was supposed that Pr(6)O(11) could promote a certain step in ethanol oxidation, and that the special morphology of the nanorods could further enhance the activity compared with nanoparticles. Based on the RNA polymerase II subunit (RPB2) sequence comparisons, the isolates were identified as N. There was insufficient evidence for the panel to make recommendations or suggestions for the use of PMRT for patients with T1-2 tumors with one to three positive axillary nodes or for all patients receiving neoadjuvant systemic therapy. Role of organic matter in copper mobility in a polymictic lake following copper sulfate treatment (Courtille Lake, France).

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According to our experience, percutaneous vertebroplasty is an effective alternative treatment of painful oncologic spine disease. The mammalian Ah receptor (AhR) is a ligand-activated transcription factor with multiple functions in adaptive metabolism, development and dioxin toxicity in a variety of organs and cell systems. During non-REM sleep the predominant component is an N550, best seen in the averages of elicited K-complexes. The AAC and EEP, in addition to deep hypothermia and DHCA, minimized the risk of cerebral embolism after distal arch aortic replacement by the left lateral approach. Determination of LC50 and sub-chronic neurotoxicity of diesel exhaust nanoparticles. Estimation of scatter component in SPECT planar image using a Monte Carlo method. Three separate samples of men and women completed the muscle dysmorphic disorder inventory (MDDI), the bodybuilder image grid (BIG) or both to measure 1-week test-retest reliability, internal consistency, convergent and divergent validity and valid placement of BIG figures along interval scales of body fat and lean muscle mass. Seasonal affective disorder is effectively treated by exposure to bright light (phototherapy or light therapy), a novel antidepressant treatment. Isolated unilateral hypoglossal nerve paralysis caused by an atlanto-occipital joint synovial cyst.

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Domain mapping is used in conjunction with a finite difference scheme on a staggered grid to solve for the temperature and flow fields. Interactions of chlorpromazine with phospholipid monolayers: effects of the ionization state of the drug. The immune efficacy of DNA vaccines containing three plasmids encoding gB, gC, and gD glycoproteins (Mix DNA) of Pseudorabies virus (PRV) or the plasmid for gC only (gC DNA), killed virus (KV) vaccine or combination of gC DNA, Mix DNA and KV vaccines was evaluated in mice using primeboost strategy. Most TGFbeta gene responses in human epithelial cells are dependent on BRG1 function. These topics are approached in the context of developing therapeutic and preventative strategies.

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Diffuse cavernous hemangioma of the left leg, vulva, uterus, and placenta of a pregnant woman. However, significant scientific advances and research discoveries that occurred during the past 50 years have presented additional facts that the immune system does interact with the central nervous system with mutual influence. We defined multiple autoantibody positive as two or more autoantibodies in venous serum and DBS screen positive if one or more autoantibodies were detected. When competing for resources, two Drosophila melanogaster flies of the same sex fight each other. For a pharmacokinetic property, the consensus score of a set of models (20 or 30) was found to improve the correlation coefficient and reduce the standard error significantly. The index profile could be accurately modeled by a modified Fermi function, with significant improvement over the step-index model. Presented herein are the findings of examining a total of 66 patients suffering from lower limb varicosity complicated by trophic ulcers, to have been subdivided into 3 groups depending on the vegetative reaction of the cardiovascular system to the orthostatic test.

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More symptomatic (S) PE were exudates, although the difference was not statistically significant (p greater than 0.1). Further investigation is warranted to categorize phenotypes of both breast and endometrial tumours in this subgroup. Can a coordinated system of care improve the quality of care for people with dementia?. The ascorbate level was measured by a high performance liquid chromatography system with an electrochemical detector. Acute ethanol intoxication effected an elevation of 5-hydroxytryptophol levels, while 1 week of treatment with ethanol appeared to have no effect on either metabolite when measured 24 h after the last dose. A descriptive analysis of the data was made and the association between different variables was explored. We used a statewide hospital discharge database to test the hypothesis that long-term anticoagulation (LTA) increases the likelihood of traumatic ICH and subsequent mortality in this patient population. Measures to identify women likely to be susceptible include assessment of age, vaccination history, and/or antibody testing. Autoantibodies, polymorphisms in the serotonin pathway, and human leukocyte antigen class II alleles in chronic fatigue syndrome: are they associated with age at onset and specific symptoms?. Prolidase deficiency (PD) is an inherited disorder associated with cutaneous ulcers, intellectual disability, unusual facial appearance, skeletal deformities, hematological anomalies, splenomegaly, and chronic infections.

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Mutations of E-cadherin have been identified in half of lobular breast cancers and diffuse-type gastric cancers, two tumor subtypes with remarkably similar pathological appearances including small rounded cells with scant cytoplasm and a diffuse growth pattern. Synthesis and mycobactericidal properties of metal complexes of isonicotinoyldithiocarbazic acid. It is also distinguished by the high prevalence of obstructive sleep apnea syndrome (OSAS), i.e., repetitive upper airway collapse during sleep resulting in hypoxia and sleep fragmentation. We report the association of linear IgA dermatosis with hematologic malignancy (chronic lymphatic leukemia and plasmacytoma) in two patients. After intrapulmonary administration of loteprednol, only a slight, statistically nonsignificant reduction in thymus weight was observed in a dose range far less than the therapeutically relevant doses. Circulating DNA is utilized widely as a genetic biomarker in a variety of pathological conditions, mainly in cancerous conditions. Similarly, pontine afferents from the dorsal column nuclei terminated somatotopically in the caudal half of the contralateral pontine gray in that gracilopontine fibers distributed caudal to cuneopontine fibers. Fractionation of lymphocyte subpopulations which regulate mixed lymphocyte reactions.

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A specific vascular system of the mucosa is responsible for temperature regulation of the inspired air. In the absence of functional pendrin (Slc26a4 (-/-) mice), aldosterone-stimulated chloride absorption is reduced, which attenuates the blood pressure response to this steroid hormone. Vpx is essential to overcome a block of early infection steps in primary monocytes. Multiple copies of the manipulated image were saved with various levels of superimposed noise. The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. The pattern changes for different incident angles of the ultrasound and can be enhanced by a quasi-static electric field. Diode-pumped passively mode-locked Nd:KGd(WO(4))(2) laser with 1-W average output power. In this paper some of the relevant in vitro test systems such as the lymphocyte stimulation test, the determination of the B cell differentiation capacity in vitro and the demonstration of suppressor cell activity are discussed.

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A variety of measures of rodent anxiety-like behavior were examined, including behavior in the hole board, elevated plus maze, light/dark box, social interaction test and unconditioned acoustic startle. Gadolinium inhibition of ecto-nucleoside triphosphate diphosphohydrolase activity in Torpedo electric organ. To assess the prevalence of self-reported adverse drug reactions (ADRs) and DAll in a paediatric population and to investigate children reporting suspected DAll in order to achieve a firm diagnosis. An ectopic expression screen reveals the protective and toxic effects of Drosophila seminal fluid proteins. Academic difficulty and program-level variables predict performance on the National Physical Therapy Examination for licensure: a population-based cohort study. The need for wider and appropriate utilization of aspirin and statins in the treatment and prevention of cardiovascular disease. The chest X-ray findings seemed normal, but a computed tomography (CT) scan showed multiple nodules in both lower lung fields. Femtosecond pulse generation in a laser with a nonlinear external resonator.

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Observations from the International Collaboration on Infective Endocarditis Prospective Cohort Study (ICE-PCS) database. The elevation of the standard of medical education in the Philippines, the purpose of medical associations. This review examines the effect of neurotrauma on the pharmacokinetics of phenytoin alongside clinical outcomes and questions the current dosing and therapeutic monitoring practices within this area. Educational inequalities in cancer mortality differ greatly between countries around the Baltic Sea. In contrast, under alkaline conditions, only a handful of the alanine mutants are capable of forming fibrils, suggesting that more side chains are involved in stabilizing interactions here.

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(2) What role does it play in muscle fatigue and other diseases?. Computed tomography (CT) is a sensitive, noninvasive radiographic technique which can produce detailed cross-sectional images of any anatomic region. Our results showed the probability of an injury having 10 or more lost workdays was 0.52 for coal mine cases versus 0.35 for metal/nonmetal mine cases. We report a rare case of fibroma of the tendon sheath arising from the fat pad in the knee. In the present work, we use a global structured metapopulation model integrating mobility and transportation data worldwide. In addition, we found that mixed females had higher clutch hatching success in the populations where orange females were frequent.

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Pediatric health care providers need to be aware of such practices and their potential complications. Once-daily d-MPH-ER at 20 mg, 30 mg, or 40 mg is a safe and effective treatment for adults with ADHD. Physicians should consider complications of paraovarian anomalies in the differential diagnosis. The splicing factor PSF is part of a large complex that assembles in the absence of pre-mRNA and contains all five snRNPs. Neurological findings were also present in patients with no previous surgical treatment for TN. All amaryl maximum daily dose nodose and fungal lesions cleared after griseofulvin therapy. C-reactive protein, interleukin-6, and tumor necrosis factor-alpha levels in overweight and healthy adults. Acylphosphatase (AcP) activity in prokaryotes was classically attributed to some aspecific acid phosphatases. Disease of the arterial media, which begins in childhood with the deposition of calcium in the vessels, may be an important cause of arterial hypertension.

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The purpose of this paper is to provide a brief overview of the evidence linking continued smoking to disease progression and adverse treatment outcomes across a range of common chronic diseases: cardiovascular disease (CVD), chronic obstructive pulmonary disease (COPD), diabetes, asthma, cancer, and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Treatment with TSLP rapidly enhances the barrier function of cultured HNECs, together with an increase of tight-junction proteins ativan generic names claudin-1, -4, -7, and occludin. In addition, a mild atrophy of the media of the aorta was detected in BDL rats. An amplified fragment length polymorphism survey was used to compare the genetic variation of native and invasive nematode populations in China and to examine the changes in genetic diversity during the invasion process. Quantitative aspects related to the representation of binary strings through cyclic states are equated, and then related to the planning and analysis of several experiments. Social work, siblings, and SIDS: conceptual and case-based guidance for family system intervention. We also found that the p53 family proteins bind to, and activate, the promoter of the DEC1 gene. This amphiphilic molecule was easily incorporated into the bilayers of liposomes. Complications of loop ileostomy and ileostomy closure and their implications for extended enterostomal therapy: a prospective clinical study. We first discuss race perception problem formulation and motivation, while highlighting the conceptual potentials of racial face processing.

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burgdorferi lp25 plasmid maintenance) and bb0665 (a gene encoding a glycosyl transferase) were higher in TLR1/2-deficient mice than in control animals. A phase I-II study of weekly cisplatin and gemcitabine with concurrent radiotherapy in locally advanced cervical carcinoma. In conclusion, this study provides further insight into the cardioprotective effects of relaxin, which also involve mast cell inhibition, and confirms the relevance of histamine in the pathophysiology of ischemia-reperfusion-induced cardiac injury and dysfunction. The animals were applied 8 mg (1/100 LD(50)) and 16 mg (1/50 LD(50)) of the preparation on the tail skin for 4 hours daily for a period of 28 days. Virtual endoscopic images of flat elevated cancer with shallow ulcer were similar to those findings by conventional endoscopy. Ferulic acid, isoquercitrin, rutoside and quercitrin were identified as major phenolic compounds in this study. Finally, our experimental approach is widely applicable to other DNA bridging proteins, as well as to complex DNA interactions involving multiple DNA molecules. The electrode was characterized (electrode slope, selectivity, optimal pH range, response time, life time). Impaired fasting glucose and left ventricular diastolic dysfunction in middle-age adults: a retrospective cross-sectional analysis of 2971 subjects. Chemical specificity in three-dimensional imaging with multiplex coherent anti-Stokes Raman scattering microscopy.

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Intraperitoneal administration of interferon beta in ovarian cancer patients. We show here, using in situ hybridisation, that when chicks are trained for 15 neurontin dose renal min with an imprinting stimulus, expression of c-fos mRNA in the IMM rises to a maximum at or before the end of this training period. Effect of drugs on the activity of lactate dehydrogenase and its isoenzymes. Presented data reveals that plumbagin is a novel, effective, anti-metastatic agent that functions by down-regulating MMP-2 and u-PA gene expressions. While drug therapy and medical management improved markedly over the last decade, the basic clinical characteristics of the heart failure patient population treated at the study hospital changed little. In the long-term a laparoscopic Nissen fundoplication had a significantly lower recurrence rate than a Thal fundoplication, particularly in patients with underlying neurological disorders.

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Consideration should be given to dynamic radiographs and interspinous distance when assessing for pseudarthrosis. Underdeveloped lateral head of the bifid condyle was excised at the level of condylar neck under general anesthesia. Transtubular potassium concentration gradient: a useful test to estimate renal aldosterone bio-activity in infants and children. Clinicopathological profile and management of 161 cases of actinic cheilitis. There is improvement of lateral chest wall and diaphragmatic motions in AIS patients six months after posterior spinal fusion, associated with subjective symptomatic improvement. Time trend and geographic patterns of lung adenocarcinoma in the United States, 1973-2002. A 14 year-old female presented with complaints of painless enlargement of the right parotid gland and facial asymmetry. The polyester tenormin tablet 50 mg uses phantom revealed a diffusion anisotropic structure according to its shape and would be utilizable repeatedly under the same conditions, differently from living central neuronal system.

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Metatarsalgia is the main symptom of a group of frequent ailments characterised by pain in the balls of the feet. Please stent was compared with its uncoated counterpart and a paclitaxel free but polymer coated version. Here, we demonstrate that Escherichia coli RNA polymerase (RNAP), which never encounters chromatin in vivo, behaves similarly to Pol II in all aspects of transcription through the nucleosome in vitro. Amino acid metabolism and protein synthesis in lactating rats fed on a liquid diet. Isometric tension was recorded from strips of bovine tracheal smooth muscle in which the tone had been artificially raised by agonist drugs such as histamine and carbachol. Our results suggest that school smoking policies may not have a direct effect on daily smoking but may reduce smoking on the school premises.

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If folic acid is shown to improve the efficacy of antidepressants, then it will provide a safe, simple and cheap way of improving the treatment of depression in primary and secondary care. Evaluation of the Influence of Modified TiO2 Particles on Polypropylene Composites. To track the 2-year movement of cardiac rehabilitation patients through the stages of change for dietary fat reduction and increasing fruit and vegetable intake. Determination of total CO2 in plasma by automated flow-injection analysis. Tumor neutralization, immunotherapy, and chemoimmunotherapy of a Friend leukemia with cells secondarily sensitized in vitro: II. The temperature-sensitive hemagglutinin (Tsh) is a representative of the growing subfamily of secreted bacterial virulence is 10 mg of paxil enough factors, known as serine protease autotransporters of the Enterobacteriaceae (SPATEs).

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Polariton local states in periodic Bragg multiple-quantum-well structures. In some epithelia a small number of irregularly distributed basal cells stained positive with AE2, indicating heterogeneity in the basal cell compartment. Ethinylestradiol, a known endocrine disruptor, may trigger DNA methylation of the estrogen receptor beta gene causing decreased mRNA resulting in impaired brain estrogen signaling in progeny. Also, with this approach, the limitations associated with the original hybridization model are succinctly stated. Medical errors, drug-related problems, and medication errors: a literature review on quality of care and cost issues. Relationship of word- and sentence-level working memory to reading and writing in second, fourth, and sixth grade. The Colombian population demonstrated greater severity of periodontitis, with significantly deeper mean probing pocket depth, and had a significantly lower percentage of current smokers.

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