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Anxionil (Lorazepam)
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Anxionil

Lorazepam is a drug used for treating anxiety. It is in the benzodiazepine family, the same family that includes Valium, Xanax, Klonopin, Dalmane, and others. It is thought that excessive activity of nerves in the brain may cause anxiety and other psychological disorders. Gamma-aminobutyric acid (GABA) is a neurotransmitter, a chemical that nerves in the brain use to send messages to one another. GABA reduces the activity of nerves in the brain. Lorazepam and other benzodiazepines may act by enhancing the effects of GABA in the brain. Because lorazepam is removed from the blood more rapidly than many other benzodiazepines, there is less chance that lorazepam concentrations in blood will reach high levels and become toxic. Lorazepam also has fewer interactions with other medications than most of the other benzodiazepines. The FDA approved lorazepam in March 1999.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Cenforce, Lopid, Cleocin, Zantac, Neoral, Tricor, Diovan, Theolair

Also known as: Lorazepam

Description

Anxionil, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration.

Anxionil is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Anxionil affects chemicals in the brain that may become unbalanced and cause anxiety. Anxionil is used to treat anxiety disorders.

Anxionil may be habit-forming and should be used only by the person it was prescribed for. Anxionil should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Dosage

ake this medication by mouth with or without food as directed by your doctor. The dosage is based on your medical condition, age, and response to treatment.

If directed by your doctor, use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Overdose

In cases of a suspected Anxionil overdose, it is important to establish whether the patient is a regular user of Anxionil or other benzodiazepines, since regular use causes tolerance to develop. Also, one must ascertain whether other substances were also ingested.

Signs of overdose range through mental confusion, dysarthria, paradoxical reactions, drowsiness, hypotonia, ataxia, hypotension, hypnotic state, coma, cardiovascular depression, respiratory depression, and death.

Early management of alert patients includes emetics, gastric lavage, and activated charcoal. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil.

Patients are ideally nursed in a kind, nonfrustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. Opportunistic counseling has limited value here, as the patient is unlikely to recall this later, owing to drug-induced anterograde amnesia.

Storage

Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Anxionil is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Anxionil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Anxionil should be avoided in people with:

Allergy or hypersensitivity – Past hypersensitivity or allergy to Anxionil, to any benzodiazepine, or to any of the ingredients in Anxionil tablets or injections

Severe respiratory failure – Benzodiazepines, including Anxionil, may depress central nervous system respiratory drive and are contraindicated in severe respiratory failure. An example would be the inappropriate use to relieve anxiety associated with acute severe asthma. The anxiolytic effects may also be detrimental to a patient's willingness and ability to fight for breath. However, if mechanical ventilation becomes necessary, Anxionil may be used to facilitate deep sedation.

Acute intoxication – Anxionil may interact synergistically with the effects of alcohol, narcotics, or other psychoactive substances. It should, therefore, not be administered to a drunk or intoxicated person.

Ataxia – This is a neurological clinical sign, consisting of unsteady and clumsy motion of the limbs and torso, due to failure of gross muscle movement coordination, most evident on standing and walking. It is the classic way in which acute alcohol intoxication may affect a person. Benzodiazepines should not be administered to already-ataxic patients.

Acute narrow-angle glaucoma – Anxionil has pupil-dilating effects, which may further interfere with the drainage of aqueous humor from the anterior chamber of the eye, thus worsening narrow-angle glaucoma.

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Their structures and the relative stereochemistry of 1 were deduced on the basis of spectroscopic methods. Fourteen patients with primary lung cancer undergoing anatomic pulmonary resections were the subjects of this study. This study considers the random placement of uniform sized spheres, which may overlap, in the presence of another set of randomly placed (hard) spheres, which do not overlap. Therefore, values for zinc, copper, manganese, chromium, selenium, molybdenum, cobalt and aluminum were estimated from food intake data from the 1993 Tottori Prefecture Nutritional Survey. The present work shows, however, that peritoneal macrophages from HSL null mice hydrolyze cytosolic stores of cholesteryl esters at a comparable rate to that of peritoneal macrophages from wild-type mice, therefore demonstrating that HSL is not the main NCEH in macrophages. This observation has at times been ascribed to genetic anticipation, but could also be due to biases related to case ascertainment or follow-up or to temporal changes in IBD epidemiology.

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Laboratory training in the retrosigmoid approach using cadaveric silicone injected cow brain. Microscopic polyangiitis complicated with ileal involvement detected by double-balloon endoscopy: a case report. Angiotensin II enhances beta-adrenergic receptor-mediated vasorelaxation in aortas from young but not old rats. This model was developed using general-purpose descriptors such as extended functional groups, molecular fragments and E-state indices. The aim of this study was to investigate whether the preoperative ratio of atrial natriuretic peptide (ANP) to brain natriuretic peptide (BNP) reflects atrial fibrosis and can be used to predict the maze procedure outcome in patients with mitral valve disease. This study aimed to analyze the impact of chronic steroid maintenance (CSM) vs early steroid withdrawal (ESW) in kidney transplant recipients (KTRs) stratified by the level of human leukocyte antigen (HLA) mismatch. The long-term effect of calcium hydroxide application on dentin fracture strength of endodontically treated teeth. Together these data suggest that Bid represents a sensor that allows cells to initiate apoptosis in response to widespread adventitious proteolysis. The Role of Endothelial Progenitor Cells in Postnatal Vasculogenesis: Implications for Therapeutic Neovascularization and Wound Healing. The aim of this study was to investigate whether proclination of the maxillary central incisor near a cleft leads to gingival recession in patients born with unilateral cleft lip and palate.

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Expression in mammalian cell cultures reveals interdependent, but distinct, functions for Star and Rhomboid proteins in the processing of the Drosophila transforming-growth-factor-alpha homologue Spitz. Aspergillus petrous apicitis associated with cerebral and peritubular abscesses in an immunocompetent man. This review presents evidence to support a role for the sarcK(ATP) or the mitoK(ATP) channel as either triggers and/or downstream mediators in the phenomenon of IPC. Donor and recipient function 2 to 4 years after renal homotransplantation. The characteristics of the sensing system are dependent on the parameters of the hollow waveguide cell. However, direct approaches to intra-axial lesions in the brainstem still carry a high risk of morbidity because the neuronal structures can be injured along the entry routes.

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(13)C NMR and electron ionization mass spectrometric data-activity relationship model of estrogen receptor binding. Upstream of the WASP family proteins, receptor tyrosine kinases, G-protein-coupled receptors, phosphoinositide-3-OH kinase (PI 3-kinase), and the Rho family of GTPases receive and transduce the signals that lead to actin nucleation through WASP-Arp2/3 action. This new AECD is safe and effective in detecting, monitoring, and treating spontaneous arrhythmias. These novel treatment modalities will hopefully permit a more selective and effective suppression of pulmonary inflammation and bronchoconstriction in patients with allergic asthma compared to local treatment with corticosteroids. Ultrafast photoinduced dynamics of halogenated cyclopentadienes: observation of geminate charge-transfer complexes in solution.

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Current pharmacological treatment of functional dyspepsia is largely empirical and involves anti-secretory or prokinetic drugs. The fluorescence enhancement of the membrane by histidine is based on favorable extraction of histidine into the bulk organic membrane and complexation with the inner metallopophyrin moiety and inhibiting the electron transfer process. Effects of chronic alcohol administration on changes of extracellular dopamine and serotonin concentration induced by methamphetamine--comparison of two different alcohol preference rat lines. Role of magnesium in the enzyme-linked immunosorbent assay for lipopolysaccharides of rough Escherichia coli strain J5 and Neisseria gonorrhoeae. Simultaneous analysis of oxidized and reduced glutathione in cell extracts by capillary zone electrophoresis. The mechanism is not linked to preservation of ADC and mitigation of secondary energy depletion during early reperfusion. We found that the drug induced apoptosis in activated lymphocytes through activation of the mitochondrial apoptotic pathway. DW-MRI is a potentially useful method for characterizing the stromal microenvironment of tumors. The pterotic branch is secondarily absent in scoloplacids and astroblepids.

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ERPs were more positive between 300 and 600 ms for visually learned as compared to both auditorily learned and new names, resembling an N400 priming effect. Although omics technologies advance rapidly, there are several challenges that need to be overcome: Next generation sequencing can efficiently decipher genomic sequences, epigenetic changes, and transcriptomic variation in patients, but it does not automatically indicate how or whether the identified variation will cause pathological changes. Public health has an important and critical role in responding to emerging multidrug-resistant organisms, such as carbapenem-resistant Enterobacteriaceae. Evidence is accumulating that the cancer microenvironment plays an active role in disease progression, and efforts are being made to target this interplay between cancer cells and host cells, to improve the prognosis of the disease. Thus, the purpose of this study was to investigate the distant effects of glioblastomas and metastases on white matter using diffusion tensor imaging (DTI). A 60 year-old man with a past medical history of AMAN developed ALS 9 years later. The effects of phytohemagglutinin (PHA) were studied in irradiated mice to see if a definite myeloproliferative effect could be demonstrated in vivo.

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Efficacy of Colloidal Silver-Hydrogen Peroxide and 2-Bromo-2-nitroporopane-1,3-diol Compounds Against Different Serogroups of Legionella pneumophila Strains. Aroma profile of Garnacha Tintorera-based sweet wines by chromatographic and sensorial analyses. Laparoscopic cholecystectomy is the gold standard for lithiasis of the gallbladder. Structural and functional aspects of ribosome interaction with endoplasmic reticulum membranes. Implications of genetic epidemiology for the prevention of tobacco use. Radiobiology of the spinal cord with special reference to late reactions. On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia. Conversion of a signal into forces for axon outgrowth through Pak1-mediated shootin1 phosphorylation. No significant complication were observed, except one case symmetrel medication dogs of transient incontinence.

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Association of child marriage with suicidal thoughts and attempts among adolescent girls in Ethiopia. Various cutaneous lesions are the main clinical features of syphilis. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy. Enhanced oral bioavailability of paclitaxel by coadministration of the P-glycoprotein inhibitor KR30031. Treatment of idiopathic juvenile arthritis with intraarticular triamcinolone acetonide injections.

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Highly stable performance of catalytic methane dehydrocondensation towards benzene on Mo/HZSM-5 by a periodic switching treatment with H2 and CO2. We find that the oxidation-number sum rule is valid in many situations, although exceptions occur for each material studied, most notably when exposed to small oxidative ligands. A 6-month follow-up computed tomography showed regression of pulmonary thromboembolism and well-positioned stent-graft without graft migration, aortacaval communication or endoleak. Facet-dependent solar ammonia synthesis of BiOCl nanosheets via a proton-assisted electron transfer pathway. Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex. There was a mutual stimulation of proliferation between fibroblasts and carcinoma cells.

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