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Angizem (Diltiazem)

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Angizem works by relaxing the blood vessels in your heart and body. This reduces your blood pressure. This drug also lowers your heart rate and dilates your coronary arteries. This means that your heart doesn't have to work as hard to pump blood throughout your body.

Other names for this medication:
Altiazem, Angizem, Cardem, Cartia, Coriem, Dicard, Dilacor, Dilcardia, Dilcontin, Dilcor, Dilgard, Dilocor, Dilter, Diltia, Diltiaz, Diltiazem, Dilticard, Diltime, Diltp, Dilzem, Heartil, Masdil, Onzem, Taztia, Tiamate

Similar Products:
Klonopin, Ditropan, Sinequan, Floxin, Glyburide, Myambutol, Amoxil, Abilify, Antivert

Also known as: Diltiazem


Diltiazem is used alone or together with other medicines to treat angina (severe chest pain) or hypertension (high blood pressure). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Diltiazem is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, diltiazem relaxes the blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain diltiazem. It may not be specific to Angizem LA. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended-release tablet, extended-release capsule, or tablet whole. Do not open, crush, or chew it. It is best to take the extended-release capsule on an empty stomach.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 120 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once a day, either in the morning or evening. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if needed. Children—Use and dose must be determined by your doctor.

For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 180 to 240 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 to 240 milligrams (mg) once a day, either in the morning or at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diltiazem can be fatal.

Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Angizem LA dosage information

Side effects

The most common side effects associated with Angizem are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Angizem if you are allergic to diltiazem, or if you have:

a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker); very low blood pressure; or if you have recently had a heart attack and you have a build-up of fluid in your lungs.

To make sure Angizem is safe for you, tell your doctor if you have:

kidney disease; liver disease; congestive heart failure; or if you also take digoxin, or a beta blocker (such as atenolol, carvedilol, metoprolol, propranolol, sotalol, and others).

It is not known whether Angizem will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Diltiazem can pass into breast milk and may harm a nursing baby. You should not breastfeed while using this medicine.

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Counts were performed without treatment, after a week of taking loratadine 10 mg daily and after 3 days of adding prednisolone at 0.6 mg/kg/day (maximum 40 mg). We report an unusual case of leukostasis in an adult who presented with multiple high attenuation intracranial masses on CT. From a systems biology perspective, this can be explained by the extensive changes that aneuploidy brings about in both the transcriptome and the proteome of a cell. Combination therapy with BMP-2 and a systemic RANKL inhibitor enhances bone healing in a mouse critical-sized femoral defect. Metabolism of caffeine is decreased in patients with alcoholic liver cirrhosis. Intravenous insulin tolerance tests showed identical effects on plasma glucose when a bolus of 0.1 U/kg was injected. RNA of the C hepatitis virus was detected in the K HLV strain stored, for 24 years, at the Museum of the Viruses Research Institute, Russian Academy of Medical Sciences, in a lyophilizated bed at -5 degrees C, however, an attempt to genotype the RNA failed. The clinical outcomes of laparoscopic antireflux surgery (LARS) in patients with the spectrum of nonspecific spastic esophageal motor disorders (NSSDs) are not known.

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Effect of the lowering and raising body temperature of the host (white rat) on the course of P. Cases of tumors where preoperative biopsies gave incomplete information are presented: sebaceous carcinoma versus basal cell carcinoma (BCC), invasive versus in situ squamous cell carcinoma (SCC), and SCC versus keratoacanthoma. The present review discusses the current state of knowledge about cellulolytic enzymes production by Trichoderma species and the encoding genes, as well as the involvement of these proteins in the lifestyle of Trichoderma. Alterations in the sugar metabolism and in the vacuolar system of mesophyll cells contribute to the desiccation tolerance of Haberlea rhodopensis ecotypes. Frequenin, a member of a large family of myristoyl-switch calcium-binding proteins, functions as a calcium-ion sensor to modulate synaptic activity and secretion. Chromosome replication and the division cycle of Escherichia coli B/r.

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Dibutyryl (db) -cAMP induced active CREB and increased the levels of CD86 by 24 hr. The purpose of this review is to summarize current available information relating to the potential effect of walnut polyphenols in health maintenance and disease prevention. Globally, studies designed to assess the effects of nutritional support on the outcome of critically ill patients, rarely fulfil basic quality requirements and should therefore be interpreted cautiously. Exploring poverty: skeletal biology and documentary evidence in 19th-20th century Portugal. Professional continuous glucose monitoring (CGM), which produces a glucose reading every 5 min, is a powerful tool for retrospective identification of unrecognized hypoglycemia. Primary structure and active site of a general phosphocarrier protein (HPr) from Salmonella typhimurium. Assessment of heating effects in skin during continuous wave near infrared spectroscopy. The ultrasonic session was performed with a 512-element phased-array transducer system operating at 1 MHz under stereotactic conditions with thermometric real-time MR monitoring performed using a 1.5-T imager. Thumb- and finger-sucking in toddlers and school children in The Hague.

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Three cycloartane glycosides from Cimicifuga rhizome and their immunosuppressive activities in mouse allogeneic mixed lymphocyte reaction. It is also shown that the study of a Kondo-NEM phenomenon provides additional (as compared with standard conductance measurements in a nonmechanical device) information on retardation effects in the formation of a many-particle cloud accompanying the Kondo tunneling. The derivation applies to the bistable, excitable, and Turing unstable regimes. Neurological complications of acute leukemia in adults: changing rate. Improving the measurement of sexual health-related indicators builds the evidence base on scientific knowledge of sex, sexuality, sexual health and rights. Cathelicidin is augmented in cholesteatoma epithelium, and the data in the present study are in agreement with the hypothesis that cathelicidin is likely to act as a key component in the first line of defense at the surface epithelium. For instance, as hypothesized, Mexican-American patients were more likely to report physical symptoms than their Anglo-American counterparts. Our study aims at evaluating the rates of early surgical complications after hemiarthroplasty in different age groups, comparing operations performed by consultants and residents.

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Our recent RT-PCR analysis revealed that E2 stimulated TGF-alpha-mRNA and EGF-receptor mRNA expression. However, little information is available on polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) using EBUS-TBNA samples in patients with intrathoracic granulomatous lymphadenopathy (IGL). Their precise role, and the particular function of court diversion/assessment schemes, is still being defined. Purification of campesterol and preparation of 7-dehydrocampesterol, 7-campestenol and campestanol. Value and limitations of the LHRH test in patients with amenorrhea-galactorrhea. Its overexpression is also speculated to be correlated with chemoresistance to doxorubicin. Hemodynamics of the lower extremities in patients with decubitus ulcers using the ultrasonic Doppler method. The use of high-throughput approaches to sequence DNA and to detect copy number variants is revealing a landscape of mutations in genetic epilepsies, affecting a variety of genes involved in neuronal excitability, synaptic transmission, neuronal metabolism, or network development. Engineering a 3D vascular network in hydrogel for mimicking a nephron.

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Obesity as a risk factor for the onset of type 2 diabetes mellitus. A mathematical approximation of the angle of closure from retruded contact. Results of this study suggest that glycopyrrolate is superior to atropine in ameliorating the adverse effects of imidocarb. The therapeutic process in cross-cultural perspective - a symposium. These findings suggest that at least two metabolic pathways for 2C-B are operative in rats. Whereas practices on maternity wards are crucial for optimal initiation, continuous lifestyle modifying and supporting approaches are essential for breastfeeding maintenance. Accumulating evidence demonstrates the critical role played by macrophages in tumor initiation, development, and progression. In addition, the recreational athletes displayed greater discrete peak knee abduction angles than the Division I athletes regardless of condition. In some patients with brachial plexus lesions, the C7 spinal nerve from the opposite side is divided and used as a nerve transfer to re-innervate the injured brachial plexus. The greater ambition and more sophisticated approach in combined intervention arms resulted in requests for more intensive expert support, which seemed crucial in their success.

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Solubility-reducing agents in honey and partly-refined crystalline sugar. Alternative energy sources for atrial ablation: judging the new technology. Full necropsy of five squirrels from the epidemic showed that all had moderate to severe infestation with mange mites and severe dermatitis characterized by hyperkeratosis, acanthosis, intralesional mites, intracorneal pustules and superficial bacteria. Single-centre experience with tunnelled central venous catheters in 150 cancer patients. An improved method for the identification and correction of RR intervals was employed prior to HRV analysis. Transformation of the ability to synthesize type polysaccharide antigen and beta-hemolysin has been obtained in group F streptococci. An Analysis of the Spectrums between Different Canopy Structures Based on Hyperion Hyperspectral Data in a Temperate Forest of Northeast China. Diagnostic accuracy of a novel method for detection of acute transmural myocardial ischemia based upon a self-applicable 3-lead configuration. Second, early sensory input regions in occipital, temporal, piriform, mid-insular, and primary sensory cortex were frequently engaged during affective experiences driven by visual, auditory, olfactory, gustatory, and somatosensory inputs. To assess outcome at six months post stroke and the unmet needs and adherence to the secondary prevention advice among survivors living at home.

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Based on the evidence of an increased phosphorylation of ERK1/2 induced by exogenous SN, we performed the radioactive binding assay. Because of its multiplex nature, it is frequently used in bulked segregant analysis (BSA). Functional studies of mutations in the human protoporphyrinogen oxidase gene in variegate porphyria. We have developed a proteomic approach for identifying phosphopeptide binding domains that modulate kinase-dependent signaling pathways. The long bevel of the reusable Quincke-type spinal needle may have contributed to the development of this complication. With the use of a conventional cuffed endotracheal tube, with the cuff partially in the right mainstem bronchus and partially in the trachea, we successfully managed the case with single-lung ventilation. Mutagenicity was studied by the Ames Salmonella assay and the bacterial fluctuation test and was dependent on particle size in both systems, ie, the greatest activity was associated with the smallest particles. Based an recent data, aphids modulate the microbiomes of plants and thereby affect the overall outcome of the biological interaction.

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This male-specific vasculature, which includes the development of a large coelomic vessel, develops coincident with expression of Sry and formation of testis cords. Morphology analysis indicates that the primary weld of the Ag microwire and the Cu substrate was located at the edge of the Ag microwire and produced via the redeposition and local melting-induced welding of the ablated materials. Genetic control of cell proliferation and the evolution of the cell cycle. Regarding routine application of localized hyperthermia, there is a series of essential problems still to be solved. According to the MLR analyses, numbers of AEDs, refractory epilepsy, comorbidity depression, and cognitive function were demonstrated to be predictors of HRQoL dependent on different tools. This study tested whether density-dependent competition has an energetic role in self-thinning, by manipulating the abundance of the fish Macquaria novemaculeata and tank size to partition the effects of competition from metabolic scaling. These results suggest that esophageal reflux of duodenal contents plays an important role in the pathogenicity of proliferative esophagitis and the potential development of esophageal adenocarcinoma. We studied skeletons of Jomonese of the period 5000-2300 years BP, of Japanese of the 17th-19th century Edo Period, and of Ainu of the 18th-20th century in Japan with special emphasis on spinal ligament ossifications as in the posterior longitudinal ligament. The effect of different feeding schedules on the growth of Bantu babies in the first week of life.

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Immunohistochemical staining of paraffin-embedded tissue with antibodies to Sirt1, FoxP3, TIA-1, and CD8 was performed. Functional association of cytokine-induced SH2 protein and protein kinase is there a difference between propecia and generic finasteride C in activated T cells. In addition, the gastrointestinal mucosa expresses receptors of the T1R and T2R families (taste receptors) and several members of the transient receptor potential channel family, all of which are putatively involved in the detection of specific tastants in the lumen. A second look at comorbidity in victims of trauma: the posttraumatic stress disorder-major depression connection. There are no evidence-based guidelines available on this subject. After 48 hours the brain was removed and expression of VEGF studied immunohistochemically on paraffin sections.

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Although the use of grafts from living donors is standard practice in transplantation in children, their use in adults remains controversial. It discusses the risks associated with ART and the importance of the need to inform patients of them so that they can make considered decisions. Neuraminidase treatment of the tissue section was a prerequisite for the positive cell staining. The Bobath concept, also known as neurodevelopmental treatment, is a widely used approach in the rehabilitation of hemiparetic subjects in many countries. Captopril v aldosterone to plasma renin activity ratio in screening for primary aldosteronism. Child physical abuse and child sexual abuse accounted for variance in current suicidal ideation. These effects seem to be related, at least partially, to the modulation of A1 adenosine receptors.

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An analysis of cases brought under the law suggests that discrimination claims within a particular market fare better than those challenging decisions to relocate or alter the market served. Elementary processes in the hydrolysis of ATP by sarcoplasmic reticulum membranes. Although the data are not fully consistent, it seems that obesity increases the risk of asthma and compromises asthma control. Perceptions of the built environment in relation to physical activity and weight status in british adolescents from central England. It is concluded that local surveys are necessary in the towns with highest rates to uncover differences in numbers of births in hospital, in obstetric techniques and in quality of medical care. The patient was extubated uneventfully 24 hours postoperatively. We highlight potential problems and pitfalls in cases of Salzmann nodular degeneration by reporting the case of an 84-year-old man with reduced visual acuity due to particularly extensive bilateral Salzmann nodules and moderate cataracts. History of glaucoma surgery (I): From Graefe to the first steps of filtering surgeries.

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The esthetic results satisfied both clinician and patient expectations. Quantitative diversity of 67 kda protective antigen among serovar 2 strains of Erysipelothrix rhusiopathiae and its implication in protective immune response. Comparisons between tumor and normal samples from the three patients tenormin cost as well as between carefully mapped peripheral and core specimens from the same tumor (excised from one of the patients), were performed. The purpose of surgery was classified into three groups: drug-resistant or persistent disease (7 patients), hemoptysis (3), and the others. However, changes in WMH volume and cortical thinning from 73 to 76 years are not associated longitudinally in these relatively healthy older subjects. The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome. Assessing data adequacy for clinical research: reliability and validity of a surgical database. The findings may provide pointers to health professionals about ways in which they can improve support for heart transplant recipients and their families. Compound 1 inhibits hypoxia-induced activation of the VEGF gene promoter in Hep3B human liver tumor cells, in vitro. We conclude that failing heart shows decreased total CPT and CPT II activities and carnitine deficiency that may be related to ventricle function.

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