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Amiwel (Amitriptyline)

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Amiwel is an antidepressant medication that is sometimes prescribed off-label to manage chronic back pain. It is one of the drugs in a class of drugs known as tricyclic antidepressants. Amiwel is not a narcotic (opioid) drug, and there is not usually an addiction risk with the medication.

Other names for this medication:
Amicon, Amicure, Amidez, Amitin, Amitrac, Amitrim, Amitriptyline, Amitryn, Amitwix, Amity, Amiwel, Amixide, Amline, Amypres, Anitryp, Arpidox, Eliwel, Endep, Eptanol, Kamitrin, Libotryp, Librodep, Lodep, Maxitrip, Mitryp, Raitrip, Relidep, Ristryl, Sarotena, Sereval, Tablin, Tadamit, Tridep, Triplent, Trixide, Tryline, Tryptomec, Typteez, Zodep

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Also known as: Amitriptyline


{name} (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

{name} is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amiwel dosage information


If you overdose Amiwel and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Amiwel overdosage: seizures, loss of consciousness for a period of time, seeing things or hearing voices that do not exist, agitation, feeling drowsy, rigid muscles, vomiting, high temperature, cold body temperature, problems concentrating, abnormal heartbeats, confusion.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amiwel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Amiwel if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Amiwel if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Amiwel is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Amiwel is not approved for use by anyone younger than 12 years old.

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The data provided in this study may be useful in designing selective therapy for painful neuropathy using synthetic hydroxamate MMP inhibitors. Concomitant influence of occupational and social risk factors on health of workers engaged into powder metallurgy. The expression of the inhibitor of apoptosis protein c-IAP1, which inhibited the function of executioner caspases 3 and 7, was studied. Biochemical markers of bone turnover such as osteocalcin, bone-specific alkaline phosphatase, crosslinks in urine, 25-hydroxy vitamin D (25-OH vitamin D), parathyroid hormone, calcium and free testosterone were determined by standard assays. flavus and the production of aflatoxin in contrast with irradiated samples alone. This report underlines the potential diagnostic problems raised by this unusual type of carcinoma and emphasizes the role of immunohistochemistry in assessing the correct diagnosis.

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The cells exhibited cooperative binding with a binding constant of 1.18 x 10(6) M-1. In a search for novel mechanisms of resistance to adriamycin, we searched for genes that are related to adriamycin resistance using the budding yeast Saccharomyces cerevisiae and identified several genes (Akl1, Bsd2, Ssl2 and Erg13, etc.). Amounts of metals in the alimentary tract were either several times higher than in the diet ingested by larvae or than in the fat body. Beclometasone Dipropionate Reference Standard (Control 011) of National Institute of Health Sciences. The NOx:creatinine ratio could be useful for the serial evaluation of disease activity. Prostaglandin (PG) E(2) is synthesized from arachidonic acid by cyclooxygenase (COX) and acts as a regulator in ovulation and fertilization reactions. To evaluate the immune response to surgery circulating lymphocyte populations and natural killer cells were determined by flow-cytometry, and IL-6 serum levels were measured by enzyme-linked immunosorbent assay. The desirable activation of oxygen scavenging in AA-WPI film at high a(w) and neutral pH in the presence of metal catalyst suggests that such AA-WPI films can be used to protect foods that have the highest vulnerability to oxidation.

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Retrospective view of the various phenotypes 20 persons affected by classic solitary form of vitelliform macular dystrophy, in 3 pedigrees with autosomal dominant transmission and in 4 single cases. In the current study we examined the role of the progesterone derived neuroactive steroid allopregnanolone (ALLO) on stress arousal, inhibitory control and drug craving in cocaine dependent subjects. Glucosidase specific activity in all brain regions exhibits two peaks, at 8 g and 32 g foetal weights. Allowances were made for the change in the percentage cellularity and distribution of active marrow in the whole skeleton as a function of age. Small cell carcinoma of the ovary of the hypercalcemic type presenting in a 5-year-old girl. Density dependent regulation of growth in L-cell suspension cultures.

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Herpesvirus (HSV-1, EBV and CMV) infections in atherosclerotic compared with non-atherosclerotic aortic tissue. The recommendations for use of bone graft substitutes and bone graft extenders are based on the strength of the studies and given a grade. The genomes of eight distinct gamma-herpesviruses have been sequenced, and the resulting database of information has enabled the identification of genetic similarities and differences between evolutionarily closely related and distant viruses of the subfamily and between the gamma-herpesviruses and other members of the herpesvirus family. New echocardiographic techniques may be useful to accurate and noninvasively diagnose certain conditions which may otherwise remain undiagnosed with traditional techniques. Perceptions of head nurses, clinical nurse specialists, nursing educators, and nursing office personnel regarding performance of selected nursing activities. The functional residual capacity was given the least importance than the other lung volume parameters. The area under the ROC curve (AUC) of AST to determine metabolic syndrome was not significant and was significantly lower than AUCs of ALT, AST/ALT, and GGT in both sexes.

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Cell death has traditionally been described as necrotic or apoptotic based on morphological criteria. This growth exponent is larger than what one would expect from theoretical considerations of two-dimensional coarsening of small molecular liquid mixtures in the viscous regime. This study is longitudinal and therefore, has fewer limitations than cross-sectional studies published to date in the Nursing literature in Brazil. Purification and properties of methionyl-tRNA synthetase from E. The contrasting behaviour of bridged amido-cyclopentadienyl (constrained geometry) group 15 chlorides and cations derived therefrom. Assembly of NiO/Ni(OH)2/PEDOT Nanocomposites on Contra Wires for Fiber-Shaped Flexible Asymmetric Supercapacitors. APE has a marginally favourable strain state in cancellous bone and spreads loads more at the cement interface than MBT. Bioavailability and metabolism of mometasone furoate following administration by metered-dose and dry-powder inhalers in healthy human volunteers.

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A descriptive comparative study was conducted, which comprised 132 fathers of children born to teenage mothers (Group A) and the same number of fathers of children born to older mothers (Group B). Heart rate, blood pressure, cardiac output (CO), peak and mean gradients as well as effective orifice area (EOA) were measured. We removed an aspergilloma located in the right lower lobe of the lung in a 48-year-old woman with a bronchial cyst and rheumatoid arthritis. Magnolol pretreatment prevented the sepsis-induced increase in NO concentration, iNOS expression, and MDA concentration, and decrease in SOD activity in LPS-treated animals. Furthermore, the apolipoprotein epsilon4 allele (APOE epsilon4) may be associated with Pick disease. Vasopressin and terlipressin produce vasoconstriction via stimulation of V1-receptors. Prevention of acute GVHD in mice by treatment with Tripterygium hypoglaucum Hutch combined with cyclosporin A. Paediatric Liver Clinic and Paediatrics Inpatient Department of Nilratan Sircar Medical College and Hospital, Kolkata, Eastern India, from April 2009 to March 2011.

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Sulfate (SO4(2-)), formic acid (HCOOH), acetic acid (CH3COOH), 4-aminophenol, 4-nitrophenol were identified in the irradiated solutions. Assessment of Choroidal Topographic Changes by Swept-Source Optical Coherence Tomography After Intravitreal Ranibizumab for Exudative Age-Related Macular Degeneration. However T allele and TT genotype frequency among hypertensive men was higher than in normotensive men. The primary planned end point was incidence of chemotherapy-induced early menopause. By contrast, ammonia-oxidizing Thaumarchaeota and Nitrobacter spp. Z-shaped sliding osteotomy for advancing mandible in micrognathia.

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A novel shadow-imaging technique to measure charge distribution and lattice displacement. The process presented could be adopted in other contexts to advance the evaluation of primary health care functions with quality tools. Though some parameters of the theory are still somewhat uncertain, self-consistent and physically realistic values can be assigned that lead to almost exact prediction of experimental micelle sizes and critical micelle concentrations for two distinctly different ionic detergents. Here, we performed a mass spectrometry-based search for FXR-interacting proteins in human hepatoma cells and identified AMPK as a coregulator of FXR. Lansoprazole significantly increased the mean 24-hour intragastric pH and the percentages of time intragastric pH was above 3 and 4 when children were dosed with either 15 or 30 mg according to body weight. The aim of this meta-analysis was to quantitatively summarize the effects of the two recently reported ADRA2A single nucleotide polymorphisms (SNPs) rs553668 and rs10885122 on T2D risk. The principle of the BSE-test, its evidence as well as steps for prevention and control of BSE are presented. The second set analyzes the differences between prioritizing admissions by expected LOS or patient severity.

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The synthesis of a number of amino acids in a combined culture of azotobacter and yeasts of the genera Candida and Torulopsis. However, as a consequence, infection has now become one of the leading causes of morbidity and mortality. Therefore they should be well-equipped in detecting suspicious lesions during routine clinical practice. Providing a simple educational pamphlet to patients before their MRI examinations that illustrated motion degradation and emphasized the need to remain still significantly reduced the number of repeated sequences deemed necessary by the MRI technologist. Binding of apolipoproteins to ABCA1 may also enhance the activity of this lipid-transport pathway. Cigarette smoking increased during heroin self-administration in comparison to drug-free and methadone detoxification conditions in eight heroin addicts given naltrexone placebo (P less than 0.01) and three heroin addicts given buprenorphine placebo. Co-Design Method and Wafer-Level Packaging Technique of Thin-Film Flexible Antenna and Silicon CMOS Rectifier Chips for Wireless-Powered Neural Interface Systems. Full-color-image retrieval is demonstrated through five mean free paths of a turbid medium. Synergistic effect between prelimbic 5-HT3 and CB1 receptors on memory consolidation deficit in adult male Sprague-Dawley rats: An isobologram analysis. Maximum binding of HCG was associated with maximum serum levels of progesterone.

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In Western countries, age-related macular degeneration is the leading cause of legal blindness in the population over 60 years of age, and cataract is the leading cause of visual impairment worldwide. The presence of serum proteins in the antigens changed their specific reactivity in all the tests. bovis to cattle, and compare the distribution of lesions in cattle infected with either of two different strains of M. The effects of varying tissue-equivalent gas composition in a tissue-equivalent ionisation chamber were investigated. The precontrast T1 of blood and myocardium are increased noroxin antibiotic in amyloidosis extending diagnostic utility in patients who cannot receive Gd. A better understanding of the different types of seizures and their etiologies may help in the prevention and treatment of status epilepticus. Mean serum concentration of ANG in women with benign tumors and with ovarian cancer 410.8 pg/ml (range: 98.3-956.3 pg/ml) and 469.1 pg/ml (range: 65.3-1103.0 pg/ml), respectively. Feeding and defecation of Rhodnius (hemiptera: Reduviidae) fed human blood. pneumoniae plays a role in persistent cough, the prevalence of C. Placebo-controlled comparison of the selective serotonin reuptake inhibitors citalopram and sertraline.

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Dysregulation of the hepatocyte growth factor (HGF)/MET pathway has been implicated in various cancers. The amplitude- and phase-frequency characteristics of the system are obtained, which contain information about the relaxation processes at the interface and in the bulk phases. Genetic location of certain mutations conferring recombination deficiency in Escherichia coli. A properly functioning adaptive immune system signifies the best features of life. Here, we review progress in our understanding of neuronal and glial cell biology during the past ten years, with an emphasis on glial cell fate specification, apoptosis, the cytoskeleton, neuronal polarity, synaptic vesicle recycling and targeting, regulation of the cytoskeleton by extracellular signals, and neuron-glia interactions.

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