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Alfacalcirol (Calcitriol)
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Alfacalcirol

Alfacalcirol is a synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Alfacalcirol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. Alfacalcirol receptor-binding protein appears to exist in the mucosa of human intestine.

Other names for this medication:
Alcee, Alfabond, Alfacip, Arachitol, Biocal, Biocitral, Bonestat, Bonetuf, Calbec, Calbory, Calcicare, Calcigra, Calcikind, Calcit, Calfa, Calosto, Calsure, Caltin, Caltop, Calzem, Cholical, Denscal, Devita, Duracal, Fovit, Kurecal, Laretol, Nutribone, Osteobel, Ostriol, Politrol, Primacal, Qpcal, Rical, Ritoca, Rockbon, Roical, Rolsical, Solbiocal, Sorvate, Statbone, Sunmic, Vezocal

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Benicar, Vasotec, Rulide, Terramycin, Ceftin, Floxin, Arcoxia, Dulcolax, Arava

Also known as: Calcitriol

Description

Generic Alfacalcirol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacalcirol are intestine and bone. Generic Alfacalcirol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacalcirol may also act on the kidney and the parathyroid glands. Generic Alfacalcirol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacalcirol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacalcirol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacalcirol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacalcirol produces other independent beneficial effects. Alfacalcirol is also known as Calcitriol. Generic Alfacalcirol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacalcirol is Calcitriol. Brand name of Generic Alfacalcirol is Alfacalcirol.

Dosage

Generic Alfacalcirol is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Alfacalcirol suddenly.

Overdose

If you overdose Generic Alfacalcirol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Alfacalcirol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Problems in older adults have not been reported with intake of normal daily recommended amounts. Studies have shown that older adults may have lower blood levels of vitamin D than younger adults, especially those who have little exposure to sunlight. Your health care professional may recommend that you take a vitamin supplement that contains vitamin D.

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Evaluations after 5 weeks and after 3 months of LEV treatment demonstrated significant improvement in depression and anxiety. Adult animals exposed to hypoxia at the age of 7 days exhibited elevated basal corticosterone level and lengthened immobility time. Having controlled for outcomes (Categories of Auditory Performance and Speech Intelligibility Rating), the cost-effectiveness improved over time. CaN inhibitors are also beneficial to cognitive outcomes in animal models of traumatic brain injury (TBI). Electrophysiological actions of peripheral hormones on melanocortin neurons. With recent technological advances in wastewater treatment, it is now possible to produce reclaimed water of any quality. Peripheral blood mononuclear cells from 54 women with a history of successful pregnancy and 30 women undergoing preterm delivery (PTD) were stimulated with the mitogen and antigens, and the cytokine levels in mitogen-stimulated culture supernatants assessed. An Yb:glass regenerative amplifier directly side pumped by four 20-W diodes is demonstrated.

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We report the ultrastructural findings and observations in animal fat associated lipoid pneumonia from two children following a cultural practice of forced feeding with animal fat (ghee). Measurement of urinary porphyrins and porphyrin precursors in Dutch hospital laboratories: a review of quality control over 5 years. We adopted this system for the screening of three triazole-pyrimidine derivatives that would ideally prove to be effective against L. Inflammation associated with a loss of epithelial barrier function and unregulated exposure of the mucosal immune system to luminal antigens leads to inflammatory bowel disease (IBD), a relatively common disorder with severe morbidity and a limited therapeutic repertoire. Fat, total cell and megakaryocyte content of sections of aspirated marrow of normal persons. It is unknown whether the respiratory chain-bound translocase transports preproteins and how the switch between sorting form and motor form occurs. Epidemiologic features and clinical subgroups of anotia/microtia in Texas.

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The tissue damping (G), tissue elastance (H), airway resistance (Raw), and hysteresivity were obtained by fitting the impedance data to three different models: a constant-phase model by Hantos et al. The quantitative insulin sensitivity check index (QUICKI) was calculated from fasting blood samples as an estimate of insulin sensitivity. The ability of their expressive language showed no difference between them. A case of aphonia following a long-time endotracheal intubation is presented. The need to consider age-related epilepsy syndromes is particularly important in children with epilepsy. Incorporating effective education programs that improve adherence to hand hygiene guidelines into the continuing education curriculum of health professionals is recommended. Green kiwifruit modulates the colonic microbiota in growing pigs. The 2D technique was associated with significantly more treatment interruptions but did not differ from 3D with regard to treatment efficacy. Isolation of rat telencephalic neural explants to assay Shh GABAergic interneuron differentiation-inducing activity. No similar equivalence can be shown for the reflection grating ring phase conjugator.

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Progressive supranuclear palsy (PSP) is a distinctive form of neurodegenerative disease which affects the brainstem and basal ganglia. It is a metabolic disorder associated with dysfunction of several organs such as atherosclerosis, altered lipid metabolism, and liver injury. To develop methods of detecting endocrine toxicity of environmental chemicals in amphibians, we have started to assemble a biomarker tool kit for an emerging amphibian model, Silurana (Xenopus) tropicalis. In concentric hypertrophy, telediastolic rigidity increased in proportion to ventricular thickness and mass. Acute phase proteins and heterophil:lymphocyte ratio in laying hens in different housing systems. The antibodies recognize a surface-exposed antigenic site that is conserved on all Pseudomonas aeruginosa strains tested to date. To observe the relationship between dipyridamole- induced ischaemia and the secretion of NT-proBNP. To dispel some of the conceptual confusion in the field of evidence-based practice that has resulted from the overlapping use of the terms research, evidence, and knowledge. A promising new application of SRS is high-dose radiosurgery delivered to the pituitary stalk.

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This suggests that the cost of dispersal over hostile surrounding habitats may be high. Only 28 cases of congenital cystic eye have been reported in the literature. The medical records of patients diagnosed with celiac disease from 1 April 1999 to 31 March 2007 were reviewed. This result, together with available empirical evidence, suggests that violations of rationality in humans and animals are consistent with natural selection, as the latter operates under constraints. Chlorpyrifos exposures of adults and children were measured using urine biomonitoring following use of over-the-counter products on dogs. Efficient manipulation of graphene absorption by a simple dielectric cylinder. At each visit urologists assessed fatigue, pain, and sexual, urinary and bowel dysfunction.

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Our results support the use of sunitinib to control renal tumor lesions in metastatic patients. Each dimension can determine the success or failure of communication. A total of 1,461 patients with the pain syndromes headache, neuropathic pain, back pain or algiomuscular pain and arthralgia were enrolled in the analysis. For high-speed acquisition, deviations from the optimal scheme do reduce the information collected but fortuitously also reduce certain types of errors, making the scheme very robust. Taken together, these results suggest that assessment of the displacement and SI of the posterior lobe of the pituitary on T1-weighted MR images is useful for the diagnosis of pituitary adenoma.

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Production of thermotolerant and alkalotolerant cellulolytic enzymes by isolated Nocardiopsis sp. We present the case of an 8-year-old boy who was injured in a bicycle accident and was admitted with a right frontal skull fracture, an acute epidural hematoma, a right frontal laceration, and a subperiosteal hematoma on admission. Studying the degradation processes in muscle tissue during long-time storage in a refrigerator by measuring the spatial-temporal dynamics of biospeckle patterns is carried out. We hypothesize that there is a more extensive origin and capsular contribution than previously described. As shown in the present study, only one conjugate in each series gave satisfactory anti-tumor protection: namely, I-octyl butyrate and poly(ethylene glycol 1000) dibutyrate respectively. 1, young males housed with adult females gained more weight and had heavier sex accessory organs than did young males housed with an adult male or reared alone. Nifedipine and prazosin in the management of pulmonary hypertension in CREST syndrome.

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To test this possibility, we have analyzed the evolution and the function of plant SMG7 homologs. Concentrations of Fe, Mn, Zn, Cu, Pb, Cr and Ni were found to be higher in these sediments when compared to concentrations found in samples from the natural environment, where an Enrichment Factor (EF) index was used to distinguish between natural and anthropogenic sources. This review provides a literature-based system to assess the predictability of achieving primary wound closure. The efficacy of individual markers for prediction will be discussed in this paper. These results suggest that dietary sesame seed and its lignan stimulate ascorbic acid synthesis as a result of the induction of UGT1A and the 2B-mediated metabolism of sesame lignan in rats. Therapy for ankle sprains focuses on controlling pain and swelling.

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Molecular Characterization and Serology of Leptospira kirschneri (Serogroup Grippotyphosa) Isolated from Urine of a Mare Post-Abortion in Brazil. Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report. We demonstrate that softer polymer-based probes can be inserted into the olfactory bulb of a mouse and that slow insertion of the probes reduces astrocytic scarring. Novel bioreactors for the culture and expansion of aggregative neural stem cells. The EDNRA antagonist negated the antisteroidogenic actions of EDN1 but only partially abolished the actions of PGF2alpha in vitro. Direct histologic continuity between mesonephric duct remnants and hyperplastic glands with numerous cytotelolysosomes and lack of intracellular mucin and carcinoembryonic antigen are the features that distinguish FMH from minimal deviation adenocarcinoma of the endocervix. In 2005, abundance of nematodes was generally higher than in the previous crashes, nematode sex ratio was negatively associated with host age and tended to be negatively associated with nematode intensity. siRNA knockdown of nonmuscle myosin II isoforms, -IIA and -IIB, resulted in opposite effects on macropinocytosis induced by PMA or IGF.

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there is no established definition of healthy aging in clinical practice, although it is a World Health Organization goal. Fourteen antineoplastic agents were examined for in vitro antibacterial activity against 101 aerobic and anaerobic bacterial isolates representing indigenous human microflora and selected opportunistic pathogens. Microarchitectural changes in trabecular bone were analyzed by microcomputed tomography (microCT) and histomorphometry in 24 patients with corticosteroid-induced osteoporosis. In the nucleoli of lymphocyte cultures, being in the presence of phytohemagglutinin (PHA) for 6--72 hours, SSPs formed finger or loop-like protrusions from fibrillar centers towards the adjacent areas of the nucleoli. The methods developed with this strategy are accurate, precise, selective, robust and matrix-independent. Excitatory inputs exhibit nonmonotonic intensity tuning, whereas with tone intensity increments, the temporally delayed inhibitory inputs increase monotonically in strength. Currently three temporary cerebral protection devices are being used.

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The paper presents medical and cultural viewpoints on male circumcision throughout history. A panel of 14 microsatellite markers was applied for genotyping 350 American donkeys from 13 countries. Influence of short-term diabetes on osteocytic lacunae of alveolar bone. Laboratory rats receiving bleomycin, perioperatively and a combination of bleomycin, etoposide and cisplatin had a significant decrease in wound breaking strength five weeks after injection. We show that, with increasing randomness, the spectral gap in a 2D Mott-Hubbard insulator is destroyed first at a disorder V(c1), while antiferromagnetism persists up to a higher V(c2). The last few years have seen the development of several molecular designs to search for mutations encoding resistance to antituberculous drugs in Mycobacterium tuberculosis. The results were summarized as follows: Both T cells and B cells can produce blastogenic factor. The findings presented in this study are essential for further study of this peptide.

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An ethics framework for public health and avian influenza pandemic preparedness. The moisture content and amount of dissolved Na ions could be measured quantitatively as a function of position. To compile evidence from randomized controlled trials, case series, and case reports to identify the effectiveness of various therapeutic agents for the treatment and prevention of dermatologic effects secondary to epidermal growth factor receptor inhibitor (EGFRI) administration. The performance of the robust extensions of the AMMI model is assessed through a Monte Carlo simulation study where several contamination schemes are considered. Tumoral and macrophage uPAR and MMP-9 contribute to the invasiveness of B16 murine melanoma cells. We report two adult UESL patients that one of them survived 62 months and one is now surviving more than 65 months treated with repeated hepatic resections and radio-frequency ablations. The lower second molar was intrused and rotated to distal and inclined as negative torque.

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Secretion of hydrochloric acid in Ghosh- moduretic 25/2 5 mg bula Lai rat preparation following stimulation with histamine and pentagastrin and inhibition by gastrone and atropine. The in vitro synthesis ratios were close to the FIc/Ftotal values of the respective hemolysates. Laparoscopic cholecystecmy is the preferred method for removing the Gall bladder. In the NST, NaCl response frequencies are high even in fetuses, and remain high. Leukocyte-derived microparticles are a potential marker for systemic inflammation. Rat bone marrow cells respond to granulopoiesis inhibiting factor by a reduced incorporation of tritiated thymidine.

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Foetal mouse neural stem cells give rise to ependymal cells in vitro. However, there are only a few examples where the occurrence of apoptosis has been shown to be a direct prerequisite for developmental processes. The new method, called variable context Markov chains (VCMC), attempts to identify the context equivalence based on the evolutionary similarities between individual amino acids. There are no distinct differences in the infestation rate of long-tailed marmots belonging to different age groups since there are constant contacts between the individuals of the colony. Nitric oxide (NO) is known as the neurotransmitter responsible for penile erection. Immunohistochemistry was used to detect the presence of various cell types before and after treatment and the results measured by digital image analysis. Since the application of SRB in WWTP has environmental benefits its application is worth considering for wastewater treatment, when sulfate is present in the influent. Addition of tetrahydrobiopterin or NO prevented ribavirin-induced tube formation inhibition. We postulate that FALS mutations cause enhanced aggregation by affecting one or more steps in the pathway, and computationally test this postulate for 75 known mis-sense FALS mutants of SOD1. A high degree of molecular diversity in the cerebellar GIRK channel repertoire is suggested by labeling seen in less abundant neuron populations, including Purkinje neurons (GIRK1/GIRK2/GIRK3), basket cells (GIRK1/GIRK3), Golgi cells (GIRK2/GIRK4), stellate cells (GIRK3), and unipolar brush cells (GIRK2/GIRK3).

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Endoscopic surgical treatment of sinonasal polyposis-medium term outcomes (mean follow-up of 5 years). Simulation tools for developing policies for complex systems: modeling the health and safety of refugee communities. Cellular studies examined GSK1120212 inhibition of ERK1 and 2 phosphorylation (p-ERK1/2) as well as MEK1/2 phosphorylation and activation. To gain further understanding of the involvement of adhesion molecules in olfactory circuitry development, we examined the dynamic and cell type specific expression of a novel protocadherin, PCDH20, in the olfactory system. The relative roles of interferon (IFN) and natural killer (NK) cells in herpes simplex virus type 1 (HSV-1) infection of mice were examined. These islands were shown to have the potential to form secondary non-B DNA structures and to interfere with paxil medication 40mg higher-order chromatin folding. americana form two monophyletic and partially sympatric species and that both are distinct from the American species P.

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In support of this pathway, early adversity has been linked to changes in neural development (particularly of the amygdala, hippocampus, and prefrontal cortex), HPA axis and ANS dysregulation, and higher levels of inflammation. In this way, a single miR-21 was able to trigger the permanent hydrolysis of multiple Cps. Plasmid profiling was used as an epidemiological tool during a period of frequent Salmonella enteritidis infection in a hospital. The lack of a statistical relationship between coexisting gray and white matter deficits might suggest their different origin and the necessity for a multimodal approach in future schizophrenia studies. DNA methylation is covalent is it safe to take diflucan while breastfeeding addition of a methyl group to cytosine within the CpG dinucleotide. Development of ionic channels during mouse neuronal differentiation. 2-DE of secretory proteins was performed using IPG strips of pH 4-7.

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The fruits of hedgerow plants are a source of winter food for frugivorous birds on farmland. A scalable membrane gradostat reactor for enzyme production using Phanerochaete chrysosporium. This concept may help develop more robust machines and shed light on self-modeling in animals. Experimental results with synthetic and real data testify the performance of the proposed technique, and competitive results are achieved when comparing to the of the state-of-the-art methods. Although transposable elements are acknowledged as a major source of spontaneous mutations, the evolutionary significance of these mobile pieces of DNA remains the subjects of some debate. Differences between Cheddar cheese manufactured by the milled-curd and stirred-curd methods using different commercial starters.

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