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Acuzole (Metronidazole)
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Acuzole

Acuzole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

Other names for this medication:
Acuzole, Amebidal, Aminidazole, Amobin, Anaerobex, Anamet, Anazol, Bemetrazole, Flagemed, Ginkan, Mecozol, Metrocream, Metrodal, Metronid, Metronour, Metryl, Missilor, Nidagel, Norzol, Orvagil, Otrozol, Protozol, Rhodogil, Rozamet, Supplin, Tismazol, Tolbin, Trikozol, Trogyl, Vandazole, Venogyl, Zobacide

Similar Products:
Daklinza, Acticin, Cytoxan, Priligy, Rogaine, Zocor, Prometrium, Pamelor, Zetia

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Also known as: Metronidazole

Description

Metronidazole injection is used to treat serious bacterial infections in different areas of the body. It is also used to prevent infections in the bowels before and after surgery for some patients.

Metronidazole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is to be given only by or under the direct supervision of your doctor.

Dosage

This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Acuzole. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

The capsules can be taken with or without food. If the medicine upsets your stomach, it is best to take it with a meal or snack.

The extended–release tablet must be taken without food, 1 hour before or 2 hours after a meal.

Swallow the extended-release tablet whole. Do not break, crush, or chew it.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop using this medicine too soon, your infection may return.

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times during the day. If you need help planning the best times to take your medicine, check with your doctor.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules or tablets): For amebiasis infections: Adults—500 or 750 milligrams (mg) 3 times a day for 5 to 10 days. Children—Dose is based on body weight and must be determined by your doctor. The dose is usually 35 to 50 milligrams (mg) per kilogram (kg) of body weight per day, divided into 3 doses, for 10 days. For bacterial infections: Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually 7.5 milligrams (mg) per kilogram (kg) of body weight every 6 hours for 7 to 10 days. Your doctor may increase your dose as needed. However, the dose is usually not more than 4000 mg per day. Children—Use and dose must be determined by your doctor. For trichomoniasis infections: Adults—The tablet can be given 3 different ways: as a single dose of 2 grams, as 1 gram 2 times a day for 1 day, or as 250 milligrams (mg) 3 times a day for 7 days. The capsule dose is 375 mg 2 times a day for 7 days. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): For bacterial vaginosis: Adults—750 milligrams (mg) once a day for 7 days. Children—Use and dose must be determined by your doctor.

Overdose

Single oral doses of Acuzole, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Acuzole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Acuzole overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Side effects

The most common side effects associated with Acuzole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Another three patients had less severe, transient mental symptoms, although they could cope with these in daily life. In this article, the authors discuss different aspects (general, medical, psychosocial, economic and practical) related to outpatient parenteral antibiotic treatment of severe paediatric infections. We report a case of Epstein-Barr virus-induced haemophagocytic syndrome in a 23-year-old man, who responded to treatment with steroids and chemotherapy. Human apurinic (apyrimidinic) endonuclease/redox-factor 1 (APE/Ref-1) is an ubiquitously expressed multifunctional protein of 36.5 kDa which is encoded by a approximately 3 kb gene localized on chromosome 14. This is the first demonstration that cytosine methylation in specific sequences occurs during macronuclear differentiation and may provide a first step towards understanding epigenetic factors involved in DNA processing. Because of these special properties, GluN3A subunits act as a molecular brake to limit the plasticity and maturation of excitatory synapses, pointing toward GluN3A removal as a critical step in the development of neuronal circuitry. The infant clinically responded to treatment with topical terbinafine and ketoconazole shampoo but presented with recurrent tinea capitis 12 months later, from which T.

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Structural equation modeling demonstrated that while both childhood maltreatment and IPV were both positively associated with PTSD symptom clusters, IPV did not mediate the association between childhood maltreatment and severity of PTSD symptom clusters among acute IPV survivors. Nine patients received an additional prophylactic infusion after 6 months while the rest received no maintenance therapy. Notwithstanding some promising reports, optimization of the methods and large randomized controlled trials are still needed. A 23-year-old woman with Gerstmann-Straussler-Scheinker disease (GSS) was investigated by 1H-magnetic resonance spectroscopy (1H-MRS). A hybrid Bayesian-neural network approach for probabilistic modeling of bacterial growth/no-growth interface. Crystal structure of silkworm Bombyx mori JHBP in complex with 2-methyl-2,4-pentanediol: plasticity of JH-binding pocket and ligand-induced conformational change of the second cavity in JHBP. Hemodynamic variables, bispectral index, oxygen saturation were measured at baseline, after induction, spinal injection, and during the surgery.

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Adsorbent Assisted in Situ Electrocatalysis: An Ultra-Sensitive Detection of As(III) in Water at Fe3O4 Nanosphere Densely Decorated with Au Nanoparticles. The remaining tissues showed little or no immunochemical deposit. In vitro skin absorption studies are commonly used to estimate in vivo skin absorption in topical safety and efficacy evaluations. The measures recorded during the conduct of standardized patient handling tasks were the changes in posture (inclination) and in shape (sagittal bending, side bending, axial rotation). Kinetics of elementary steps of electron transfer in nitrogenase in the presence of a photodonor. A total of 225 CKD patients in an outpatient department were recruited for this study, among whom 170 received regular Western and Chinese medicine treatments (control group) and 55 received treatments guided by the theory of Traditional Chinese Medicine (experimental group). phialiseptus is proposed as the isolates were found by the authors to belong to A. They play a major role as extracellular mediators by activating G-protein coupled receptors (GPCRs) and stimulating diverse cellular responses from their signaling pathways. Mass spectrometric techniques applied to the analysis of human tears: a focus on the peptide and protein constituents. To understand the molecular bases of thermotolerance during BNF under heat stress, we have used cDNA-amplified fragment length polymorphism experiments to identify differentially expressed transcripts from cowpea nodules subjected to heat shock treatment.

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However, the precise roles of multicomponent transcriptional complexes have not been fully elucidated because of technical difficulties in using in vitro experimental systems. Univariate and multivariate analyses were performed to identify the factors associated with LNM. Recommendations for specimen collection for NBOMe analysis in clinical toxicology. Recently, we have proposed that C-Nap1, a novel centrosomal protein, is part of a structure linking parental centrioles in a cell cycle-regulated manner. The system utilizes an alternative oxidase (PaAOX) which uses iron instead of copper as a cofactor. The gold standard for the treatment of breast cancer includes mastectomy surgery. Relative neutralizing activity in polyspecific IgM, IgA, and IgG preparations against group A streptococcal superantigens. We showed that anaphylatoxins significantly increase chemokine mRNA expression. Australia is moving toward the use of broad consent for biobanking. This improvement was even more pronounced in patients with low caffeine levels compared with those with high caffeine levels.

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By using an AR deletion construct (AR-(Delta371-485)) as a bait, beta-catenin was identified as an AR-interacting protein from a gonadotropin-releasing hormone neuronal cell library. Predictors of delayed-type hypersensitivity to Candida albicans and anti-Epstein-Barr virus antibody among children in Kilimanjaro, Tanzania. As a consequence small programmes which are genuinely performing marginally below specific standards are likely to receive less attention than larger programmes, and even under close scrutiny the causes are less likely to be found. Several lines of evidence indicated that 6-HITC induced apoptosis in U937 cells and human stomach cancer MKN45 cells. Low concentrations of antiinflammatory glucocorticoids, such as dexamethasone, inhibit the enhanced prostaglandin E synthesis as a result of 12-O-tetradecanoylphorbol-13-acetate action. Based on these observations, we hypothesize that BHV-1 infection activates neuronal cyclin expression to enhance productive infection. However, the tolerance of these non-native microorganisms to toxic biofuels is naturally low, which has restricted the potentials of their application for high-efficiency biofuel production. Risk factors of organ/space SSI were studied in a prospective cohort including 3,908 patients from June 2003 to December 2006. Random Amplified Polymorphic DNA (RAPD) Typing of Multidrug Resistant Enterococcus faecium Urinary Isolates from a Tertiary Care Centre, Northern India.

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Anti-reflection coatings and surfaces have enabled the increasing performance demands of optical components fabricated from glass-based optical materials. The cross sectional study tried to identify some risk factors for rampant caries in a hospital based population of Nigerian children. Indirect immunofluorescence locates IQGAP1 within individual keratinocytes in a cytoplasmic pattern and along the cell periphery at adhesive sites. It is necessary to educate people about foot care, lack of which will lead to a huge financial and health burden due to preventable complications of diabetes. A study of positional variation of anatomic structures in 38 patients undergoing CT in both the supine and prone positions prior to beginning radiotherapy is reported. In comparison with other members of the bicarbonate transport superfamily, NBC4a and NBC4b are most similar structurally to the electrogenic sodium bicarbonate cotransporters (NBC1). 5-Fluoro-12-methylbenzanthryl-7-acetic acid (5-FMBAAA) is an analog of the carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) with little or no carcinogenic activity.

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Alterations in endogenous nitric oxide production after cardiopulmonary bypass in lambs with normal and increased pulmonary blood flow. Mosquito surveys were conducted during 2 days (July 22 and 28, 1998) with carbon-dioxide-baited light traps, larval and pupal collections, and landing collections. Estimated marginal means for most joint range of motion and lower extremity alignment measurements were notably higher for the hallux valgus group. Interestingly, Mediator antagonizes Hsf1 occupancy of non-induced promoters yet facilitates enhanced Hsf1 association with activated ones. By contrast, no quantitative change was disclosed in the untreated group. Counterion density profile around charged cylinders: the strong-coupling needle limit. The Janus-faced nature of IDO1 in infectious diseases: challenges and therapeutic opportunities. Degenerate four-wave mixing in silicon hybrid plasmonic waveguides.

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Neuronal oscillations in the theta and gamma bands have been shown to be important for cognition. Our findings are consistent with follicular lymphoma with marginal zone differentiation as a high-risk variant of follicular lymphoma. Seizure phenotypes, periodicity, and sleep-wake pattern of seizures in Kcna-1 null mice. They may invade nearby tissues and organs, however, and can be difficult to control. The primary objective was to assess the overall response rate (ORR).

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In the inner cellular layer, two types of CR-ir perikarya were found: numerous small CR-ir cells (granule cells) and some medium-sized CR-ir cells (putative displaced periglomerular cells). Initial studies implementing cerebral embolic protection devices in TAVR have yielded promising results with decreased neurological complications and appearance of new lesions on imaging. The new immunosuppressive drug Rapamycin (Rapa) is endowed with a mechanism of action that is distinct from that of calcineurin inhibitors. This review provides an overview of LIV and highlights areas where further effort is needed to control this disease. It has identified that EGR-1 has significant transformation suppression activity in some neoplasms, such as fibrosarcoma, breast carcinoma. Using a historical cohort study model, we tested the hypothesis that heterogeneity of emphysematous changes on the preoperative chest radiograph correlated is there any medication similar to nifedipine with favorable outcome of lung volume reduction surgery.

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The results tramadol 50 mg side effects elderly indicate that increased viremia was due to increased availability of LDV permissive macrophages, and that during a chronic LDV-P infection virus replication is strictly limited by the rate of regeneration of permissive macrophages. Tumour tissue microarray allows the analysis of hundreds of tumour samples simultaneously on a single microscope slide. Role of a secretagogue immunoglobulin in gastric acid secretion. The recurrent tumor that developed in the same region was measured 33 x 30 x 15 cm. More severe sleep difficulties have been found to be clearly related to psychiatric illness such as depression and phobias, as well as to addiction. Oral glucocorticoid use was assessed from the Swedish Prescribed Drug Register. Variables predictive of continued employment (greater than or equal to 2 ans) after surgery were similar. Gender differences were investigated by applying analysis of covariance, using age at onset and age at first psychiatric consultation as dependent variables, comorbid depression and gender as between-subject factors, and employment status, social support, and DD types as covariates. The structure of the mature GT can be divided into periventricular, central, and superficial layers, similarly to the adjacent optic tectum, but it shows different layering aspects, particularly in the retinorecipient superficial layer.

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To investigate the effects of guggulsterone on the proliferation and apoptosis of human hepatoma HepG2 cells in vitro and relevant mechanisms. Diazepam is the only benzodiazepine with increased risk of fractures after adjusting for medications and comorbidities. The present studies evaluated an index of depression in a rodent model of heart failure by measuring responses to rewarding electrical brain stimulation, which provides an experimental procedure to operationally define anhedonia in rats. Finally, while it is true that age should not be considered in isolation as a contraindication for AN, we should be aware that, in final life stages, oral feeding can be the only satisfaction left for the elderly. The state of intestinal enzymes in children suffering from dysentery and colienteritis.

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Immunofluorescence study of the development of some arboviruses in chicken fibroblast cultures, treated with monologous interferon. Rapidly growing mycobacteria should be included in the differential diagnosis of skin and soft tissue infection after cosmetic surgery. The history of teaching about microbiocenosis demonstrates various connections of microorganisms with the bowels and other organs and systems of human body. The primary purpose of this study was to assess the relationship between preoperative risk factors, postoperative chronic pain, sleep, and gender on perceptions of quality of life (QoL) in a sample of 123 coronary artery bypass graft (CABG) surgery patients 12 months after surgery. In in vitro studies, theafulvins inhibited epoxide hydrolase and glutathione S-transferase activities in a concentration-dependent manner. Resistance of the ovary to blockade of aromatization with aminoglutethimide. Similarly, combination therapy, involving either multiple medications or the combination of medication with specific psychotherapies, has not been well studied. mucilaginosa may be responsible for infections of the lower respiratory tract in predisposed patients. Prednisolone therapy induced rapid symptom remission, which was achieved within one month from the onset of asthma to the diagnosis of CSS. We conclude that the incidence rate of infection and thrombosis in our series of femoral-based hemodialysis grafts is comparable with rates reported in the literature for upper extremity polytetrafluoroethylene angioaccess grafts.

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This survey compares the different patterns of orthoptic treatment of amblyopia in the United Kingdom (UK) and three German speaking countries (GSC). MMP-2, -3, -7, -9, and -12 and TIMP-1 and -2 were identified in human aqueous humor samples from all groups of patients with a six to sevenfold molar excess of TIMPs over MMPs. Losses in acoustic energy that occur in the mixing region downstream of the perforations are modeled as fluctuations in entropy. The nursing education programme in Lithuania has passed through many changes. There is a decrease in NiTi corrosion resistance compazine supp dosing in the presence of fluoride. Glucocorticoids decrease endothelin-A- and -B-receptor expression in the kidney. A mutation at this nucleotide position has been previously suggested to be of pathogenic significance and has not been detected in any controls.

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Short lived effector cells (SLECs) confer immediate protection, but contribute little to the memory repertoire. The recently developed deconvolution method performed significantly better than the HSI based system when compared to manual counting as gold standard. The discovery of the sex-determining region of the Y chromosome (SRY) in the early 1990s was the first crucial step towards a general understanding of sex determination. Their main findings were the following: (1) During prophylactic lithium treatment the overall mortality of patients with major mood disorders was much lower than in such patients in general. With the optode membrane described, histidine in a sample solution from 0.0045 to 1.53 mM can be determined. When Free Is Not for Me: Confronting the Barriers to Use of Free Quitline Telephone Counseling for Tobacco Dependence. The levels of serum TSH and T4 were not changed significantly in this experiment. Using sequence data from the nuclear locus (gapCp) we find that the European C. The absence of an effect of overnight storage makes field studies of lymphocyte subset concentrations more feasible.

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