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Acupain (Tramadol)

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Acupain is used to relieve moderate to moderately severe pain. Acupain is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

Other names for this medication:
Acupain, Admadol, Arrestadol, Bludol, Cemadol, Combitram, Cosdol, Dolex, Gemodol, Inodol, Ivydol, Kevtram, Leedol, Nosdol, Omodol, Opigesic, Radol, Ryzolt, Sayodol, Tamody, Taxidol, Tradol, Traiz, Tramacip, Tramared, Trambax, Tramest, Tramol, Trapidol, Trazac, Tromfil, Tryme, Typhon, Unidol

Similar Products:
Mellaril, Avodart, Wellbutrin, Viagra, Arcoxia, Flagyl

Also known as: Tramadol


{name} (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

{name} is used to treat moderate to severe pain in adults.

The extended-release form of tramadol ({name} ER) is for around-the-clock treatment of pain. {name} ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Acupain ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Acupain ER.

Never share Acupain ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Acupain ER.

Acupain ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Acupain ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Acupain ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Acupain ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Acupain ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Acupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Acupain ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Acupain ER should not be given to a child younger than 12 years old. Acupain ER should not be given to anyone younger than 18 years old.

Do not give Acupain ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Acupain ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Acupain ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Acupain ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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While EEG signals of epileptic patients contain necessary information with regards to the various brain states of epileptic patients, for extraction of useful information in the EEG signals and for detection, often construction of high-dimensional feature vectors is utilized. There were also weak interactions between body art and hair colour, with blonde women in general rated more negatively than brunettes. Synthesis of the protein phosphatase 2A inhibitor (4S,5S,6S,10S,11S,12S)-cytostatin. Three-dimensional (3D) scaffolds fabricated by rapid prototyping techniques have many merits for tissue engineering applications, due to its controllable properties such as porosity, pore size and structural shape. Underwater EMR of adenomas of the appendiceal orifice (with video). The expression of vascular endothelial growth factor (VEGF) and IFN-gamma-inducible protein 10 (IP-10), and microvessel density (MVD) in tumor tissues was detected by immunohistochemistry. Prolonged treatment with metronidazole and amoxicillin-clavulanic acid resulted in an excellent outcome with normal weight bearing. Pharmacodynamic biomarkers in model-based drug development in oncology.

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Four of the genes most highly regulated by spores have only previously been associated with head and neck and lung carcinomas. Some older adults are dependent on caregivers for managing their activities of daily living (ADLs), such as dressing, and their instrumental activities of daily living (IADLs), such as transportation. A framework to combine BMI and demographic trends is essential in evaluating the burden and disparity associated with the epidemic in the aging U.S. The current review will cover the use of aspirin for the prevention of colorectal adenomas and CRC, potential markers for chemoprevention, and patient stratification. Immunoperoxidase demonstration of human serum globulin binding to islet tissue.

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Maternal plasma and fetal amniotic fluid samples were prospectively collected between 2006 and 2007 at the time of mid-trimester amniocentesis. Neurotransmitters of excitatory and inhibitory amino acids play an important role in the transmission and modulation of pain in the spinal dorsal horn. Specific removal of this component from plasma by immuno-absorption resulted in disappearance of the fast-reacting antiplasmin activity whereas alpha2-macroglobulin was found to represent the slower-reacting plasmin-neutralizing activity. However, it was unknown whether natural immunosurveillance inhibits growth of completely spontaneous autochthonous tumors, and whether it can be improved by inhibition of negative regulation. Epidemiology of venous insufficiency in an occupational population.

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These findings suggest that the choice of antipsychotic drugs should also depend on disturbance of immune system activity, in particular, those occurring in the several forms of psychosis. Although procedural variations have emerged over the past several decades, the most conventional reinstatement procedures are based on the drug self-administration (SA) model. Propranolol should be considered as a potential first-line therapy in patients with symptomatic hepatic hemangiomatosis. ICR-170-induced mutations in the CYC1 gene of the yeast Saccharomyces cerevisiae were investigated by genetic and DNA sequence analyses. Dendritic cells (DC) are important in differential T-cell priming. By cell fractionation and indirect immunofluorescence the X-protein was found at least in part associated with nuclei. The inclusion of patients who are at high risk for melanoma in follow-up programs allows the detection of melanomas in early stages, with good prognosis, even in the absence of clinical and dermoscopic features of melanoma. This article explores that question by focusing upon two policy approaches in particular: conventional regulation and self-regulation, often described as hard law and soft law, respectively. In conclusion, humans generate speech by activating two motor systems. Current clinical evidence from three small RCTs indicates progesterone may improve the neurologic outcome of patients suffering TBI.

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A method for determining the adenosine triphosphatase content of energy-transducing membranes. For cloned 5S subunit sequence shows regions of high homology with that of pyruvate carboxylase and oxaloacetate decarboxylase. The two-point results are found to match Monte Carlo simulations more closely. As well, early debridement and split-thickness skin grafting at diagnosis constitutes the best means of reducing the high socioeconomic costs and allows for early return to work. Analysis of pre-mRNA splicing status of critical cell cycle regulators showed misspliced Rb1 pre-mRNA resulting in a premature stop codon. Memantine blocked the expression of acute dependence, but was less effective in inhibiting its escalation, when hyperalgesia was used as a measure of withdrawal. Extraskeletal mesenchymal chondrosarcoma: case report and review of the literature. Low-density lipoprotein particle concentration (LDL-P) is generally more predictive of clinical cardiovascular endpoints than LDL cholesterol (LDL-C). In contrast to dual energy X-ray absorptiometry (DEXA), the most commonly used technique for measurement of BMD today, the QUS method is free of ionizing radiation, easy to handle and inexpensive. Effects of glaucoma medications on corneal endothelium, keratocytes, and subbasal nerves among participants in the ocular hypertension treatment study.

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National and regional guidelines have been developed in North America, South America, South Africa and Western Europe to assist practitioners managing patients with CAP and have demonstrated to improve patients outcome. The metabotropic glutamate receptors have a wide range of modulatory functions in the central nervous system. Assessment of insular development in small for gestational age infants. In the attempt to overcome these problems, a real-time PCR-based method for the rapid and sensitive identification and quantification of P. Septic arthritis in infants and children should always be managed by a pediatrician in close consultation with an orthopedic surgeon. These data support the growing evidence that females display a differential response and adaptation to stress than males. One transcript that declines rapidly following growth factor deprivation of hematopoietic cells is the serine/threonine kinase pim-2.

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vRNAi/eRNA-Seq indicates that v-crc acts to suppress expression of innate immune cell response, enhance expression of clotting genes in the host, and up-regulate cuticle genes. The fragments are stabilized with minimal osteosynthesis by Kirschner wires, screws, or sutures. Primary care physicians (PCPs) need a wide range of clinical information (CI) resources to manage their patients. Compared with L-Thy and valsartan group, imidapril group showed significantly lower plasma /tissue AngII concentration and more effective inhibition of extracellular matrix fibrosis. Experimental colitis was induced in mice by addition of dextran sodium sulfate to the drinking water. As a non-invasive diagnostic method, ultrasonography has proved to be a particularly valuable diagnostic tool. Additional information on predictions, including the source code under the GNU Public License can be found at Giant T wave inversion as a manifestation of asymmetrical apical hypertrophy (AAH) of the left ventricle. Three-dimensional morphogenesis of MDCK cells induced by cellular contractile forces on a viscous substrate.

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Furthermore, we predict that the Anaplasma marginale enzyme has attractive domain constituents and may be functionally different from other TMPKs. Genotyping and CA4 gene analysis in a Chinese family with retinitis pigmentosa. Affective disorder, once seen as rare in sub-Saharan Africa, is now viewed as more common. Residency Training: Determinants of burnout of neurology trainees in Attica, Greece. Therefore, our results indicated that even some soybean cultivars grown on soils with permitted levels of Cd might accumulate higher concentrations of Cd in seeds that are hazardous to human health. The patient was submitted to an endoscopic transnasal transeptal resection of a hematoma and tumoral tissue in the pituitary region. In addition, the SF-36 scores of elderly Mexican American women in our sample were compared with normed scores for the SF-36 scales in the general population of elderly US women. Women were randomized to placebo or low-dose estrogen for 7 days during the HFI. High-energy extracorporeal shock wave therapy has been shown to be an effective treatment for chronic insertional Achilles tendinopathy. Enumeration of CECs was performed with anti-CD 146-driven immunomagnetic isolation and subsequent Ulex lectin staining.

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Our results suggest a role for adenosine in vasculogenesis and its potential use to stimulate engraftment in cell-based therapies. We compiled the description of the clinical information and biochemical data of patients with StAR mutation from published manuscripts. Small recruits suffered higher mortality than large recruits on bleached and dead coral. Ophthalmic examination showed ecchymosis what antibiotic does not interact with coumadin , proptosis, and limited extraocular movements of the affected eye. This non-linear relationship is seen when energy intake reduction is not severe. The explanation for somatotype differences might be due to the significantly lower body height and higher portion of muscular profile in the mesomorphic children. However, ther are many variables which can sometimes be negative, influence the politics and process of publications. Analysis of the clinical presentation, chest radiographs, course of disease and features of severe pneumonia in 45 SARS patients diagnosed at our hospital in Beijing between April 5 - 20, 2003. Deubiquitination of FANCD2 is required for DNA crosslink repair. Despite major differences according to the approach adopted, the prevalences of infertility estimated in our study are comparable with those obtained in other similar studies.

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An efficacious, safe, and user-accepted implementation of GlucoTab was demonstrated. Waiting for treatment for chronic pain - a survey of existing benchmarks: toward establishing evidence-based benchmarks for medically acceptable waiting times. This paper aims to investigate the level of awareness and factors influencing awareness of EC among college students. The surgical plan was selected by considering the stage of stenosis, dilatation, reconstruction of hypopharynx, oesophagus or larynx. Because of the highly aggressive nature of this cancer, effective combination chemotherapy must be found if the natural history of this tumor is to be altered. Physical activity differences by experimental arm were verified on a random subsample via accelerometry. Effectiveness of rehabilitation of patients with ischemic heart disease associated with hypertension on a sanatorium health resort level (immediate and remote results). They went through between 37 and 50 training sessions with an adaptive computerized program on WM and non-verbal reasoning (NVR). Cells of a human leukemic cell line (REH) were exposed to BrdUrd for either 20 min, 8 h, or 24 h.

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Nocardia cyriacigeorgica is recognized as an emerging pathogen in many parts of the world. The proposed model can be solved by the inexact augmented Lagrangian method, and experiments on simulated and real hyperspectral images demonstrate that the proposed method is efficient for HSI denoising. No significant relationship between the results of the skin reactions and the other parameters was found. In this compendium, there are 107 sources of data on mortality, morbidity, natality, maternal and child health, health and health care, the Census, and nutrition surveillance. Also, testicular macrophage-secreted paracrine factor had additive effect on FSH-induced testosterone production, since FSH-activated TMCM that contained both FSH as well as FSH-induced testicular macrophage-secreted paracrine factor, stimulated the Leydig cell steroidogenesis more potently than FSH alone.

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It is generally understood that hypoalbuminemic patients have elevated risks for surgical procedures. Occurrence and origin of estrogenic isoflavones in Swiss river waters. A special issue is the possible toxicity of opioids with acute tolerance and central nervous system sensitisation resulting in increased pain intensity. Adjuvant chemotherapy is reserved for those tumors that progress despite surgery, and more personalized chemotherapy is being pursued with better understanding of the molecular genetics of this tumor. Compounds 1-6 were isolated from genus Discocleidion for the first time and exhibited certain inhibitory activity against Escherichia coli. The mammalian mitochondrial DNA (mtDNA) encodes for 13 proteins, including several essential for oxidative phosphorylation. The aim of the present study was to investigate the role of intraperitoneal microdialysis (IPM) techniques in monitoring the evolution of postoperative critically ill patients requiring urgent laparotomy.

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The PAS-positive cells were relatively more abundant in vascular adventitiae and zyrtec 20 mg bid nerves and less so in the general connective tissue of the dermis than were the mast cells which did not contain the second mucosubstance. In conclusion, HA effectively reduced scar formation after neurolysis. Blastogenic responses of lymphocytes from cancer patients and normal donors to phytohemagglutinin (PHA) and in one way mixed lymphocyte reactions increased in several individuals and decreased slightly in others. The choriocapillaris was the only tissue with high levels of the MAC, which was not detected in any of the 38 additional samples from 19 tissues. Great morphological variability of Apiosoma is reflected in variability of shape and size of the body and mutual arrangement of micro--and macronucleus. Magnetic field control of electron tunneling pathways in the monolayer of (ferrocenylmethyl)dodecyldimethylammonium bromide on a gold electrode. We measured genomic DNA methylation, as assessed by Alu and LINE-1 (long interspersed nuclear element-1) methylation via pyrosequencing, on 103 umbilical cord blood samples from the biorepository of the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) study group. To determine the role of gp96 in myeloid cells in host defence during Klebsiella pneumonia, mice homozygous for the conditional Hsp90b1 allele encoding gp96 were crossed with mice expressing Cre-recombinase under control of the LysM promoter to generate LysMcre-Hsp90b1-flox mice. Our results may indicate that HRV and QT dynamicity parameters can be useful noninvasive methods that may detect autonomic nervous system activity and ventricular vulnerability in OSAS.

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Phospholipase D (PLD) hydrolyzes phosphatidylcholine into phosphatidic acid (PA), a lipidic mediator that may act directly on cellular proteins or may be metabolized into lysophosphatidic acid (LPA). On the basis of the simulation results it is shown that a leading role in upgrading the virulence capacity of the agent and in replenishment of the morbid group is assigned to the asymptomatic infected individuals. Small sample population and spatial averaging inherent to this technique. Delivery of a brief motivational intervention to patients with alcohol-related facial injuries: role for a specialist nurse. Copper- vasotec Mediated Formation of Aryl, Heteroaryl, Vinyl and Alkynyl Difluoromethylphosphonates: A General Approach to Fluorinated Phosphate Mimics.

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Results in a rat model showed that both NFS and BM-MSCs contributed to the wound healing. In addition to exploring the existing literature, we retrospectively analyzed a plausible explanation of the findings of this case. Expression, characterization, and mutagenesis of a series of N-terminal fragments of an animal fatty acid synthase, containing the beta-ketoacyl synthase, acyl transferase, and dehydratase domains, demonstrate that the dehydratase domain consists of two pseudosubunits, derived from contiguous regions of the same polypeptide, in which a single active site is formed by the cooperation of the catalytic histidine 878 residue of the first pseudosubunit with aspartate 1032 of the second pseudosubunit. Non-cell-autonomous planar cell polarity propagation in the auditory sensory epithelium of vertebrates. Arterio-venous fistula of upper arm observed with injection abscess. Cocaine induces alterations in mitochondrial membrane potential and dual cell cycle arrest in rat c6 astroglioma cells. Grating-coupled surface-emitting diodes are modeled and analyzed in terms of radiation power, threshold gain, and saturation effects. Factors influencing mother-child reports singulair mg of depressive symptoms and agreement among clinically referred depressed youngsters in Hungary. HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in the Kinh population in Vietnam.

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