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Accupain (Tramadol)

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Accupain is used to help relieve moderate to moderately severe pain. Accupain is similar to opioid analgesics. It works in the brain to change how your body feels and responds to pain. Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Other names for this medication:
Accupain, Atdol, Axedol, Bestodol, Bramadol, Cosdol, Cradol, Damol, Decotram, Dolfre, Dolotram, Dolriz, Doltel, Domadol, Domaspas, Hyperdol, Ibudol, Kamadol, Lagesic, Moludol, Nosdol, Ondol, Orchidol, Paxmax, Pentazen, Postadol, Ramadol, Ryzolt, Sedate, Tandam, Tolydol, Topspas, Traceta, Tramatas, Tramest, Tramoflex, Tramospas, Tranat, Trandol, Trandy, Transic, Trasic, Tridol, Tromfil, Tryme, Vardol, Victadol, Zotadol

Similar Products:
Singulair, Seroquel, Lanoxin, Artane, Clozaril, Colospa, Epivir, Antabuse, Aygestin

Also known as: Tramadol


{name} ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Accupain: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Accupain is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Accupain dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Accupain XL dosage information

Side effects

The most common side effects associated with Accupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Phase conjugation by self-pumped Brillouin-induced four-wave mixing. Observation of extreme temporal events in CW-pumped supercontinuum. To correlate the clinical evaluation of asthma with the most usual parameters of larger and smaller airways bronchial obstruction, PFR and FEV1.n. Data obtained from karyotyping and estimation of nucleolar organizer (NO) activity in bone marrow cells from 9 patients with multiple myeloma (MM) and from 8 donors are presented. Bronchopulmonary dysplasia (BPD) is a common complication in preterm infants. The United States (US) Preventive Services Task Force (USPSTF) has recently updated its guidelines to encourage men 45 to 79 years and women 55 to 79 years to use aspirin when the potential benefit outweighs the potential harm. Retrospective review of electronic medical records of patients with NFPAs. We included 34 patients with arterial hypertension and 11 healthy individuals.

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pCPA increased mounting behavior in the non-receptive stimulus condition. In addition, uncoated and fibrinogen-coated membranes prompt stronger release of the granule enzymes, myeloperoxidase and elastase, than collagen or serum-coated alumina. Given that more than one third of some cohorts of cancer survivors exhibit post-traumatic stress disorder (PTSD) symptomatology, this study examines how trauma outcomes might relate to quality of life (QOL). After vortexing, centrifugation and freezing, the supernatant organic solvent was evaporated and reconstituted in a small volume of reconstitution solution. Anatomical evidence and conditioning experiments have suggested that magnetoreceptors innervated by the ophthalmic branch of the trigeminal nerve are located in the upper beak of homing pigeons. Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer. Without antigenic sorting, the lung spheroids recapitulate the stem cell niche and contain a natural mixture of lung stem cells and supporting cells.

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This observation suggests that such genotypes may be particularly adapted to survive cleaning and disinfection stress. Data was collected via an anonymous mailed survey distributed via State and Territory representatives on the Australian Health Protection Committee, who identified team members associated with Australian DMAT deployments from the 2004 South East Asian Tsunami disaster. Phytoplasma infection in tomato is associated with re-organization of plasma membrane, ER stacks, and actin filaments in sieve elements. Although both susceptible species develop a strong anti-viral immune response, the virus persists indefinitely throughout life, apparently at a transcriptionally silent stage, at least in a proportion of infected cells. Functional abilities were assessed by the Gross Motor Function Measure and by calculating the energy expenditure index from data collected during two three-minute walk tests (comfortable and fast speeds). Analysis of Sequence Data Under Multivariate Trait-Dependent Sampling. Spontaneous intracranial hypotension presenting with coma: a case report and literature review. Indirect exclusion of four candidate genes for generalized progressive retinal atrophy in several breeds of dogs. To our knowledge we report the first case of percutaneous mechanical thrombectomy used for the treatment of massive pulmonary embolism in the United Kingdom.

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Early and late recurrences of PCCCL are linked to different predictive factors. Recently we found a small hepatocyte-specific protein, annexin A3 (AnxA3), in fractionated adult rat hepatocytes. In addition to explaining acupuncture and the roles of both Merkel cells and C fiber tactile afferents, the model has greater implications for neuroscience, through the postulation of a new division of the autonomic nervous system. Restriction pattern analysis is a rapid identification method for non tuberculous mycobacterial strains. Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs. Geographic information systems (GIS) and other spatial analytic methods provide such a solution and thus can play a major role in cancer control.

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The aim of this work was to study the associations of physical activity (PA) and other factors predisposing to overweight, with overweight and central adiposity in children and adolescents. Trypsin also fails to enhance the growth of a thermosensitive polyoma-transformed BHK line in soft agar at the restrictive temperature. The shutter is implemented using a simple field programable gate array controlled optical switch. Biopsy demonstrated fibrous tissue with an absence of identifiable muscle fibers. Specialized interactive visual methods are required to help analysts in understanding the characteristics of the attributes when these multiple aspects are considered concurrently.

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Eight months earlier he had a subtotal gastrectomy for adenocarcinoma classified as T1 N0M0 stage IA. Research Needs in School Health: COMMITTEE ON RESEARCH, SCHOOL HEALTH SECTION. Changes in rupture formation and zonary region stained with Evans blue during the recovery process from aluminum toxicity in the pea root apex. The selection of an enterprise-wide electronic medical record (EMR) by a medical center is a major undertaking that will define its future clinical processes for many years. This article discusses a new clinical classification system of the lip-cheek groove to better manage this clinical problem. Trends and variation in incidence, surgical treatment, and repeat surgery of proximal humeral fractures in the elderly. This study enhances the hypothesis of a gland (crypt) base columnar cell that gives rise to all the intestinal lineages. The purpose of this study is comparison of clinical picture and prognosis of HM and compare it to malaria in endemic region of southern Sudan (endemic malaria - EM) among hyper-immune population. Many of them, however, lack a solid evidence base with regard to their efficacy and few have been subjected to robust randomized trials.

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Correlations between mortality from CVD and meteorological factors among subjects presenting with CHD, cerebrovascular disease, and AH were more pronounced and statistically significant compared with patients of the same groups without AH. This development was accompanied by a massive accumulation of bacterial plaque along the tooth surfaces, gingival inflammation, alveolar bone resorption, loss of connective tissue fiber attachment, apical migration of junctional epithelium, and pathological movement of the molars. Falls in the elderly constitute a major problem confronting physicians. Limited proteolysis of alpha 2M-methylamine with lysine-specific bacterial endoproteinase was examined by rate electrophoresis and by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to correlate the loss of the epitopes with the generation of defined fragments. Laboratory investigations showed anemia, severe hypokalemia, and metabolic acidosis. Ostracod, Eucypris infiata, the intermediate host of avian cestodes in the biocenosis of Lake Tengiz. It is the purpose of this paper to alert the medical community on the potential nephrotoxicity of certain agents among certain patients, especially with some types of renal insufficiency.

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An accurate preoperative diagnosis of LPSP can avoid pancreaticoduodenectomy in these patients. Characterization of Leuconostoc lactis strains from human sources. To evaluate pancreatic repair, we used a mouse model of pancreatic damage resulting in hyperglycemia, which involves injection of mice with streptozotocin (STZ). Synchronized epiaortic two-dimensional and color Doppler echocardiographic guidance enables routine ascending aortic cannulation in type A acute aortic dissection. We surveyed 855 practicing physicians selected randomly from three professional organizations. The assembly of lipid droplets and its relation to cellular insulin sensitivity.

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Her outfit is considered as one of the major criteria for care quality. The resulting monodisperse hexagons can be arranged in a 2-dimensional (2D) ordered periodical super-structure. Available data indicate that neutrophils (PMN) produce a wide range of cytokines with the potential to modulate immune response. The present study aimed to investigate how online and offline social behavior interact with each other ultimately to affect the well-being of socially anxious adolescents. It included (a) relief of spasm and pain, (b) stretching, (c) exercise, (d) alteration of the training program and (e) education to prevent future problems or worsening of the present problem.

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Weights and heights were measured of 69 (37 male and 32 female) children aged between 1 year and 18 years. Testing included a mouse inclined screen assay and an in vivo cat hypoglossal nerve-tongue preparation, as well as standard estimations of anticholinesterase activity since the candidate compounds are known to have motrin infant weight based dosing chart such a component in their activity spectrum. These results suggest that ES-induced muscle force reduced trabecular bone loss, and streptomycin treatment did not induce bone loss, but attenuated the effects of ES-induced muscle force on reducing the loss of disused bone. The chromosomal distribution of distamycin A/DAPI-, D287/170-, quinacrine-, and chromomycin A3-positive heterochromatic regions, as well as the nucleolus organizer regions, is described and compared with the karyotypes of other hominoid species. Coincidence of sporadic left atrial myxoma and benign Schwannoma of the foot erroneously diagnosed as Carney complex.

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The probability that any of these group means were equal to one another was tested using statistical software. To obtain direct evidence that the plasminogen-binding activity of the NA enhances the pathogenicity of WSN virus, we generated mutant viruses that are deficient in plasminogen-binding activity by reverse genetics. We modified an ambulatory electronic medical record (EMR)-based results management application to track pending tests at hospital discharge (Hospitalist Results Manager, HRM). Double staining revealed a close association between the blood pressure medicine bisoprolol side effects C3-fragment patches and membrane depolarization, as well as redistribution of lipid rafts to these areas. Differences in motilin receptor desensitization after stimulation with motilin or motilides are due to alternative receptor trafficking. Warfarin substantially increases the risk of bleeding in patients on dialysis. A formalism is presented for optical waveguiding by means of Bragg reflection.

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Evolution of Host-Beneficial Traits in Nitrogen-Fixing Bacteria: Modeling and Construction of Systems for Interspecies Altruism. In addition, the acidic functional group was demonstrated to be critical for the binding interaction of the small-molecule antagonists with anti-apoptotic Bcl-2 proteins. Our data show that the results of in situ hybridization applied on frozen and paraffin-embedded sections using biotinylated DNA probes, detected with an indirect streptavidin-biotin-peroxidase reaction and intensified by silver-gold enhancement, were comparable to those obtained with radioactive probes. The cesarean delivery scar pouch: clinical implications and diagnostic correlation between transvaginal sonography and hysteroscopy. Interrogating them against the historiography and building up the interconnectedness of what they reveal. A case of spontaneous puerperal rupture of an aneurysm of a branch of the right ovarian artery is reported and the histological and histochemical changes in the vessel wall are described. Effects of anesthetics and convulsants on acetylcholine content of brain. A patient with major pulmonary thromboembolism associated with recurrent placental abruption is described. Traditional smallpox vaccination with reduced risk of inadvertent contact spread by administration of povidone iodine ointment. Removal of mercury(II) from wastewater using camel bone charcoal.

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There has been an improvement in the status of stocks in the Northeast Atlantic, but our analysis suggests further reductions in fishing effort would improve long-term yields. Differentiation of species of the Baccharis genus by HPLC and chemometric methods. Diagnostic and management practices for phenylketonuria in 19 countries of the South and Eastern European Region: survey results. Measurements of vascular response (VR), HbA1c, weight and blood pressure were performed at 0, 2 and 14 months. We show that activity of the thyroglobulin promoter correlates with the presence of a thyroid nuclear factor that binds the promoter at position -60 from the transcription start site. In search for possible cozaar medication pdr novel genes that may be involved in tooth development, we analysed the genome-wide transcriptome of developing mandibular tooth germs of mouse during embryonic and early life and selected family-with-sequence-similarity-46, member A (Fam46a) gene for further expression analysis. This article reviews the potential impacts of climate change on food security.

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The role of global traditional and complementary systems of medicine in the treatment of mental health disorders. The representativeness of practice networks is important when using the information obtained to guide health policy. High-capacity adenoviral (HC-Ad) vectors were generated expressing mutant and wild-type versions of N-terminal truncated and full-length htt either in vitro in primary neuronal cells or in the striatum of mice. Estimates of the EEG correlation dimension (D(2)) and power spectra were calculated. Repositioning of the phantom resulted in large fluctuations in intensity values. Benzodiazepine treatment interferes not only with the release of CRH but also with the release of NPY and CCK. Male and female F344N rats and B6C3F1 mice received 2,4-Hx in corn oil by gavage for 16 days, 14 weeks, or 2 years. Moreover, the comparisons of all allele frequencies between Mediterranean and AfrIcan populations show the same trend, highlighting in some cases European origin and in other cases non-European origin. Such resistance is related to reduction of SS receptor (SSTR) density vasotec tabs or to a different expression of SSTR subtypes. Women indicated for this type of surgery include those at high risk of recurrence after autologous surgery resulting from defective connective tissue.

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Eicosanoids influence insect susceptibility to nucleopolyhedroviruses. The theories predict generically that thermal conductance diverges as N(1/3) as the vasotec generic name size N increases for systems terminated with heat baths at the ends. Use of non-Gaussian noise such as heavy-tailed distribution is motivated by its ability to track abrupt and smooth AR parameter changes, which are inadequately modeled by Gaussian models. Conversion during laparoscopic renal surgery to open or hand assisted laparoscopic surgery is a rare but important event in laparoscopic surgery. Detailed discussion on methods of rigid transformation, resampling, multi-resolution medical image representation and optimization for accelerated multi-resolution registration scheme is also given in this paper. The finding of a uniform density of these projections and an increase in the size implies that each granule cell axon must gain dense projections. Collagen alpha1 (I) chain precursor, collagen alpha1 (III) chain precursor, collagen alpha2 (VI) precursor and collagen modifying enzymes prolyl 4-hydroxylase alpha-2-subunit precursor, procollagen-lysine 2-oxoglutarate 5-dioxygenase 1 and 2, protein disulfide isomerase ER-60 precursor and peptidyl-prolyl cis-trans isomerase were among the abundant proteins. Estimation of alkane-water logP for neutral, acidic, and basic compounds using an alkylated polystyrene-divinylbenzene high-performance liquid chromatography column. Surveys included questions to identify the risk of asthma and related key factors.

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Randomized clinical trials on progression of renal diseases usually include patients according to criteria for BP, renal function, and proteinuria. The fibre changes point to a primary disturbance of muscle metabolism. Foreign bodies of unknown origin found in a serosal hematoma between the stomach and the pancreas of a patient. During tonic activation of excitatory synaptic inputs homogeneously distributed over the whole arborization, the Purkinje cell generates regular oscillatory potentials. Close intraarterial injection of gabapentin (0.01, 1 and 100mg/kg) dose-dependently reduced afferent firing rate in both normal and acutely inflamed rat knees in response to normal and hyper-rotation of the joint. Internal fixation gave better results than prosthetic replacement of the upper end of the femur. Optimal diagnostic cut-offs and performance were determined using receiver operating characteristic curves.

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Combined brain imaging and reversible pharmacological inactivation of motor cortical regions suggest that the recovery involves the bilateral primary motor cortex during the early recovery stage and more extensive regions of the contralesional primary motor cortex and bilateral premotor cortex during the late recovery stage. Multiple organ dysfunction syndrome (MODS) is a serious complication with higher mortality in patients with burns and trauma. Since previous in vitro research has been performed at different environmental temperatures, it is hypothesized that the temperature differences may be the reason for the conflicting reported results. The correlation between colposcopic lesions graded with RCI and histology was strong, particularly in women who had HGSIL on a Pap smear. Estimates of the collagen concentration in human ventricles have been made from measurements of the hydroxyproline concentration. More than 100 hr of observation, 70 formal interviews, numerous informal interviews, and document review were the primary data collection methods.

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